Identifying a research agenda for language teaching materials

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106808/1/modl12094.pd

Critical Transition in Tissue Homeostasis Accompanies Murine Lung Senescence

BACKGROUND: Respiratory dysfunction is a major contributor to morbidity and mortality in aged populations. The susceptibility to pulmonary insults is attributed to "low pulmonary reserve", ostensibly reflecting a combination of age-related musculoskeletal, immunologic and intrinsic pulmonary dysfunction. METHODS/PRINCIPAL FINDINGS: Using a murine model of the aging lung, senescent DBA/2 mice, we correlated a longitudinal survey of airspace size and injury measures with a transcriptome from the aging lung at 2, 4, 8, 12, 16 and 20 months of age. Morphometric analysis demonstrated a nonlinear pattern of airspace caliber enlargement with a critical transition occurring between 8 and 12 months of age marked by an initial increase in oxidative stress, cell death and elastase activation which is soon followed by inflammatory cell infiltration, immune complex deposition and the onset of airspace enlargement. The temporally correlative transcriptome showed exuberant induction of immunoglobulin genes coincident with airspace enlargement. Immunohistochemistry, ELISA analysis and flow cytometry demonstrated increased immunoglobulin deposition in the lung associated with a contemporaneous increase in activated B-cells expressing high levels of TLR4 (toll receptor 4) and CD86 and macrophages during midlife. These midlife changes culminate in progressive airspace enlargement during late life stages. CONCLUSION/SIGNIFICANCE: Our findings establish that a tissue-specific aging program is evident during a presenescent interval which involves early oxidative stress, cell death and elastase activation, followed by B lymphocyte and macrophage expansion/activation. This sequence heralds the progression to overt airspace enlargement in the aged lung. These signature events, during middle age, indicate that early stages of the aging immune system may have important correlates in the maintenance of tissue morphology. We further show that time-course analyses of aging models, when informed by structural surveys, can reveal nonintuitive signatures of organ-specific aging pathology

Purdue Road School: Funding, Funding, Funding

Municipal entities are facing many issues which are causing financial distress. This presentation will discuss strategies to assist in these difficult times. The strategies to be discussed will include short and long-term financial planning, board discussions and the creation of a capital improvement plan

"Language Learning & Teaching (LLT) Materials-in-Use" - For the MLA Panel "Are Textbooks Dead?"

PowerPoint slides for the presentation "Language Learning & Teaching (LLT) Materials-in-Use" (by Anne Marie Guerrettaz). For the MLA Panel "Are Textbooks Dead?" (Carl Blyth)

Indigenous language revitalization

Countless Indigenous languages around the world are the focus of innovative community regeneration efforts, as the legacies of colonialism have created conditions of extreme sociopolitical, educational, and economic adversity for the speakers of these languages—and their descendants. In response to these conditions that Indigenous people face globally, the burgeoning field of Indigenous language revitalization and maintenance has emerged since the 1990s with the goal of supporting speakers of these languages and future generations. Indigenous language revitalization involves different but often interlocking domains of research, practice, and activism. Given the uniqueness of each community and their desires, history, values, and culture, the significance of the local is critical to the global phenomenon that is language revitalization. For instance, cases on five different continents offer valuable insights into this field, including the Hawaiian language in Oceania; Myaamia in the United States (North America); Básáa in the Cameroon (Africa); Sámi in Finland (Europe); and, Cristang and Malay in Malaysia (Asia). These offer examples of both local resources and common challenges that characterize revitalization efforts.The field of Indigenous language revitalization is interdisciplinary in nature, exemplified through five lines of inquiry that significantly contribute to this area of research: (a) theoretical linguistics and anthropology, (b) applied linguistics, (c) education, (d) policy studies, and (e) critical studies, including postcolonial studies, Indigenous studies, and raciolinguistics. Questions of research ethics are central to the field of Indigenous language revitalization since reciprocity and collaboration between researchers and Indigenous communities matter as the lifeblood of Indigenous language revitalization work. Finally, we believe that the notion of Indigenous language revitalization pedagogies along with underexplored Indigenous concepts (e.g., from Yucatecan and Māori scholars) offer compelling directions for future research.<br/