Revealing the fastest component of the DG Tau outflow through X-rays

Some T Tauri stars show a peculiar X-ray spectrum that can be modelled by two components with different absorbing column densities. We seek to explain the soft X-ray component in DG Tau, the best studied of these sources, with an outflow model, taking observations at other wavelengths into consideration. We constrain the outflow properties through spectral fitting and employ simple semi-analytical formulae to describe properties of a shock wave that heats up the X-ray emitting region. The X-ray emission is consistent with its arising from the fastest and innermost component of the optically detected outflow. Only a small fraction of the total mass loss is required for this X-ray emitting component. Our favoured model requires shock velocities between 400 and 500 km/s. For a density >10^5 /cm^3 all dimensions of the shock cooling zone are only a few AU, so even in optical observations this cannot be resolved. This X-ray emission mechanism in outflows may also operate in other, less absorbed T Tauri stars, in addition to corona and accretion spots.Comment: 7, pages, 4 figures, accepted by A&

Seasonal and interannual variability of North American isoprene emissions as determined by formaldehyde column measurements from space

Formaldehyde (HCHO) columns measured from space by solar UV backscatter allow mapping of reactive hydrocarbon emissions. The principal contributor to these emissions during the growing season is the biogenic hydrocarbon isoprene, which is of great importance for driving regional and global tropospheric chemistry. We present seven years (1995-2001) of HCHO column data for North America from the Global Ozone Monitoring Experiment (GOME), and show that the general seasonal and interannual variability of these data is consistent with knowledge of isoprene emission. There are some significant regional discrepancies with the seasonal patterns predicted from current isoprene emission models, and we suggest that these may reflect flaws in the models. The interannual variability of HCHO columns observed by GOME appears to follow the interannual variability of surface temperature, as expected from current isoprene emission models

Prostate cancer treatment with Irreversible Electroporation (IRE): Safety, efficacy and clinical experience in 471 treatments.

BackgroundIrreversible Electroporation (IRE) is a novel image-guided tissue ablation technology that induces cell death via very short but strong pulsed electric fields. IRE has been shown to have preserving properties towards vessels and nerves and the extracellular matrix. This makes IRE an ideal candidate to treat prostate cancer (PCa) where other treatment modalities frequently unselectively destroy surrounding structures inducing severe side effects like incontinence or impotence. We report the retrospective assessment of 471 IRE treatments in 429 patients of all grades and stages of PCa with 6-year maximum follow-up time.Material and findingsThe patient cohort consisted of low (25), intermediate (88) and high-risk cancers (312). All had multi-parametric magnetic resonance imaging, and 199 men had additional 3D-mapping biopsy for diagnostic work-up prior to IRE. Patients were treated either focally (123), sub-whole-gland (154), whole-gland (134) or for recurrent disease (63) after previous radical prostatectomy, radiation therapy, etc. Adverse effects were mild (19.7%), moderate (3.7%) and severe (1.4%), never life-threatening. Urinary continence was preserved in all cases. IRE-induced erectile dysfunction persisted in 3% of the evaluated cases 12 months post treatment. Mean transient IIEF-5-Score reduction was 33% within 12-month post IRE follow-up and 15% after 12 months. Recurrences within the follow-up period occurred in 10% of the treated men, 23 in or adjacent to the treatment field and 18 outside the treatment field (residuals). Including residuals for worst case analysis, Kaplan Maier estimation on recurrence rate at 5 years resulted in 5.6% (CI95: 1.8-16.93) for Gleason 6, 14.6% (CI95: 8.8-23.7) for Gleason 7 and 39.5% (CI95: 23.5-61.4) for Gleason 8-10.ConclusionThe results indicate comparable efficacy of IRE to standard radical prostatectomy in terms of 5-year recurrence rates and better preservation of urogenital function, proving the safety and suitability of IRE for PCa treatment. The data also shows that IRE, besides focal therapy of early PCa, can also be used for whole-gland ablations, in patients with recurrent PCa, and as a problem-solver for local tumor control in T4-cancers not amenable to surgery and radiation therapy anymore

The neural correlates of speech motor sequence learning

Speech is perhaps the most sophisticated example of a species-wide movement capability in the animal kingdom, requiring split-second sequencing of approximately 100 muscles in the respiratory, laryngeal, and oral movement systems. Despite the unique role speech plays in human interaction and the debilitating impact of its disruption, little is known about the neural mechanisms underlying speech motor learning. Here, we studied the behavioral and neural correlates of learning new speech motor sequences. Participants repeatedly produced novel, meaningless syllables comprising illegal consonant clusters (e.g., GVAZF) over 2 days of practice. Following practice, participants produced the sequences with fewer errors and shorter durations, indicative of motor learning. Using fMRI, we compared brain activity during production of the learned illegal sequences and novel illegal sequences. Greater activity was noted during production of novel sequences in brain regions linked to non-speech motor sequence learning, including the BG and pre-SMA. Activity during novel sequence production was also greater in brain regions associated with learning and maintaining speech motor programs, including lateral premotor cortex, frontal operculum, and posterior superior temporal cortex. Measures of learning success correlated positively with activity in left frontal operculum and white matter integrity under left posterior superior temporal sulcus. These findings indicate speech motor sequence learning relies not only on brain areas involved generally in motor sequencing learning but also those associated with feedback-based speech motor learning. Furthermore, learning success is modulated by the integrity of structural connectivity between these motor and sensory brain regions.R01 DC007683 - NIDCD NIH HHS; R01DC007683 - NIDCD NIH HH

Thermodynamics of viscous dark energy in an RSII braneworld

We show that for an RSII braneworld filled with interacting viscous dark energy and dark matter, one can always rewrite the Friedmann equation in the form of the first law of thermodynamics, $dE=T_hdS_h+WdV$, at apparent horizon. In addition, the generalized second law of thermodynamics can fulfilled in a region enclosed by the apparent horizon on the brane for both constant and time variable 5-dynamical Newton's constant $G_5$. These results hold regardless of the specific form of the dark energy. Our study further support that in an accelerating universe with spatial curvature, the apparent horizon is a physical boundary from the thermodynamical point of view.Comment: 11 page

Combined chips for atom-optics

We present experiments with Bose-Einstein condensates on a combined atom chip. The combined structure consists of a large-scale "carrier chip" and smaller "atom-optics chips", containing micron-sized elements. This allows us to work with condensates very close to chip surfaces without suffering from fragmentation or losses due to thermally driven spin flips. Precise three-dimensional positioning and transport with constant trap frequencies are described. Bose-Einstein condensates were manipulated with submicron accuracy above atom-optics chips. As an application of atom chips, a direction sensitive magnetic field microscope is demonstrated.Comment: 9 pages, 9 figure