Convection in the Earth's core driven by lateral variations in the core-mantle boundary heat flux

Moving core fluid maintains an isothermal core-mantle boundary (CMB), so lateral variations in the CMB heat flow result from mantle convection. Such variations will drive thermal winds, even if the top of the core is stably stratified. These flows may contribute to the magnetic secular variation and are investigated here using a simple, non-magnetic numerical model of the core. The results depend on the equatorial symmetry of the boundary heat flux variation. Large-scale equatorially symmetric (ES) heat flux variations at the outer surface of a rapidly rotating spherical shell drive deeply penetrating flows that are strongly suppressed in stratified fluid. Smaller-scale ES heat flux variations drive flows less dominated by rotation and so less inhibited by stratification. Equatorially anti-symmetric flux variations drive flows an order of magnitude less energetic than those driven by ES patterns but, due to the nature of the Coriolis force, are less suppressed by stratification. The response of the rotating core fluid to a general CMB heat flow pattern will then depend strongly on the subadiabatic temperature profile. Imposing a lateral heat flux variation linearly related to a model of seismic tomography in the lowermost mantle drives flow in a density stratified fluid that reproduces some features found in flows inverted from geomagnetic data

The role of nanomaterial-protein interactions in determining the toxic consequences of nanomaterial exposure

As early biological responses to foreign objects in the body can be influenced by their bound proteins, the nanomaterial hard protein corona (the collection of slow exchange proteins that associate with nanomaterials) is an emerging area of interest in nanotoxicology. There is a limited but growing appreciation of the role these interactions have in influencing nanomaterial toxicity. This research dealt with (i) the characterisation of iron oxide and silica particles with and without a plasma, serum and lung lining fluid protein hard corona, (ii) the identification of the proteins in the hard corona that associate with the particles and (iii) the effect of the hard corona on influencing particle cytotoxicity in a J774.A1 macrophage cell line. Initial investigation of the particles illustrates the advantages in using a variety of characterisation techniques to better elucidate particle properties. Subsequent characterisation of the hard corona protein profile demonstrated a clear difference in the biological identity of the particles in a plasma, serum and in a lung lining fluid corona. Although it is difficult to associate the impact of any individual protein identified in the hard corona to cytotoxicity this study indicates that the binding of proteins plays a significant role in altering the cytotoxic potential (as determined by LDH release) in macrophages. The work also demonstrates the hard corona has an impact on macrophage chemotaxis, which further strengthens the hypothesis that the corona is a key consideration in nanoparticle toxicity. Ultimately this thesis finds that the nanomaterial hard corona is an important element to consider in experimental design and highlights the concept of creating particle preparation protocols to mimic the corona composition in vivo when examining in vitro cellular responses. This research highlights the implications for interpretation of data from in vitro cell culture tests that do not take the protein corona into consideration

Randomised field trial to evaluate serological response after foot-and-mouth disease vaccination in Turkey

AbstractDespite years of biannual mass vaccination of cattle, foot-and-mouth disease (FMD) remains uncontrolled in Anatolian Turkey. To evaluate protection after mass vaccination we measured post-vaccination antibodies in a cohort of cattle (serotypes O, A and Asia-1). To obtain results reflecting typical field protection, participants were randomly sampled from across Central and Western Turkey after routine vaccination. Giving two-doses one month apart is recommended when cattle are first vaccinated against FMD. However, due to cost and logistics, this is not routinely performed in Turkey, and elsewhere. Nested within the cohort, we conducted a randomised trial comparing post-vaccination antibodies after a single-dose versus a two-dose primary vaccination course.Four to five months after vaccination, only a third of single-vaccinated cattle had antibody levels above a threshold associated with protection. A third never reached this threshold, even at peak response one month after vaccination. It was not until animals had received three vaccine doses in their lifetime, vaccinating every six months, that most (64% to 86% depending on serotype) maintained antibody levels above this threshold. By this time cattle would be >20 months old with almost half the population below this age. Consequently, many vaccinated animals will be unprotected for much of the year. Compared to a single-dose, a primary vaccination course of two-doses greatly improved the level and duration of immunity. We concluded that the FMD vaccination programme in Anatolian Turkey did not produce the high levels of immunity required. Higher potency vaccines are now used throughout Turkey, with a two-dose primary course in certain areas.Monitoring post-vaccination serology is an important component of evaluation for FMD vaccination programmes. However, consideration must be given to which antigens are present in the test, the vaccine and the field virus. Differences between these antigens affect the relationship between antibody titre and protection

Rapidly rotating plane layer convection with zonal flow

The onset of convection in a rapidly rotating layer in which a thermal wind is present is studied. Diffusive effects are included. The main motivation is from convection in planetary interiors, where thermal winds are expected due to temperature variations on the core-mantle boundary. The system admits both convective instability and baroclinic instability. We find a smooth transition between the two types of modes, and investigate where the transition region between the two types of instability occurs in parameter space. The thermal wind helps to destabilise the convective modes. Baroclinic instability can occur when the applied vertical temperature gradient is stable, and the critical Rayleigh number is then negative. Long wavelength modes are the first to become unstable. Asymptotic analysis is possible for the transition region and also for long wavelength instabilities, and the results agree well with our numerical solutions. We also investigate how the instabilities in this system relate to the classical baroclinic instability in the Eady problem. We conclude by noting that baroclinic instabilities in the Earth's core arising from heterogeneity in the lower mantle could possibly drive a dynamo even if the Earth's core were stably stratified and so not convecting.Comment: 20 pages, 7 figure

Experimental pig-to-pig transmission dynamics for African swine fever virus, Georgia 2007/1 strain

African swine fever virus (ASFV) continues to cause outbreaks in domestic pigs and wild boar in Eastern European countries. To gain insights into its transmission dynamics, we estimated the pig-to-pig basic reproduction number (R 0) for the Georgia 2007/1 ASFV strain using a stochastic susceptible-exposed-infectious-recovered (SEIR) model with parameters estimated from transmission experiments. Models showed that R 0 is 2·8 [95% confidence interval (CI) 1·3–4·8] within a pen and 1·4 (95% CI 0·6–2·4) between pens. The results furthermore suggest that ASFV genome detection in oronasal samples is an effective diagnostic tool for early detection of infection. This study provides quantitative information on transmission parameters for ASFV in domestic pigs, which are required to more effectively assess the potential impact of strategies for the control of between-farm epidemic spread in European countries.ISSN:0950-2688ISSN:1469-440

Wheatstone bridge configuration for evaluation of plasmonic energy transfer

We propose an internal (on-chip) Wheatstone bridge configuration to evaluate the efficiency of near-field transducers (NFT) as used in heat-assisted magnetic recording (HAMR). The electric field enhancement between the transducer and the image plane is monitored by measuring the resistance of metal electrodes composing the image plane. The absorption of the enhanced electric field causes an increase in the metal temperature, and thereby, in its resistance whose variation is monitored with an internal Wheatstone bridge which is accurately balanced in the absence of the electric field

Comparison of pre-emptive and reactive strategies to control an incursion of bluetongue virus serotype 1 to Great Britain by vaccination.

Bluetongue (BT) is a disease of ruminants caused by bluetongue virus (BTV), which is spread between its hosts by Culicoides midges. Vaccination is the most effective way to protect susceptible animals against BTV and was used reactively to control the recent northern European outbreak. To assess the consequences of using vaccination pre-emptively we used a stochastic, spatially explicit model to compare reactive and pre-emptive vaccination strategies against an incursion of BTV serotype 1 (BTV-1) into Great Britain. Both pre-emptive and reactive vaccination significantly reduced the number of affected farms and limited host morbidity and mortality. In addition, vaccinating prior to the introduction of disease reduced the probability of an outbreak occurring. Of the strategies simulated, widespread reactive vaccination resulted in the lowest levels of morbidity. The predicted effects of vaccination were found to be sensitive to vaccine efficacy but not to the choice of transmission kernel

Kinematic dynamo action in a sphere. I. Effects of differential rotation and meridional circulation on solutions with axial dipole symmetry

A sphere containing electrically conducting fluid can generate a magnetic field by dynamo action, provided the flow is sufficiently complicated and vigorous. The dynamo mechanism is thought to sustain magnetic fields in planets and stars. The kinematic dynamo problem tests steady flows for magnetic instability, but rather few dynamos have been found so far because of severe numerical difficulties. Dynamo action might, therefore, be quite unusual, at least for large-scale steady flows. We address this question by testing a two-parameter class of flows for dynamo generation of magnetic fields containing an axial dipole. The class of flows includes two completely different types of known dynamos, one dominated by differential rotation (D) and one with none. We find that 36% of the flows in seven distinct zones in parameter space act as dynamos, while the remaining 64% either fail to generate this type of magnetic field or generate fields that are too small in scale to be resolved by our numerical method. The two previously known dynamo types lie in the same zone, and it is therefore possible to change the flow continuously from one to the other without losing dynamo action. Differential rotation is found to promote large-scale axisymmetric toroidal magnetic fields, while meridional circulation (M) promotes large-scale axisymmetric poloidal fields concentrated at high latitudes near the axis. Magnetic fields resembling that of the Earth are generated by D > 0, corresponding to westward flow at the surface, and M of either sign but not zero. Very few oscillatory solutions are found