Visible-light promoted atom transfer radical addition-elimination (ATRE) reaction for the synthesis of fluoroalkylated alkenes using DMA as electron-donor

Here, we describe a mild, catalyst-free and operationally-simple strategy for the direct fluoroalkylation of olefins driven by the photochemical activity of an electron donor-acceptor (EDA) complex between DMA and fluoroalkyl iodides. The significant advantages of this photochemical transformation are high efficiency, excellent functional group tolerance, and synthetic simplicity, thus providing a facile route for further application in pharmaceuticals and life sciences

Model Predictive Control for Continuous-Time Singular Jump Systems with Incomplete Transition Rates

This paper is concerned with model predictive control (MPC) problem for continuous-time Markov Jump Systems (MJSs) with incomplete transition rates and singular character. Sufficient conditions for the existence of a model predictive controller, which could optimize a quadratic cost function and guarantee that the system is piecewise regular, impulse-free, and mean square stable, are given in two cases at each sampling time. Since the MPC strategy is aggregated into continuous-time singular MJSs, a discretetime controller is employed to deal with a continuous-time plant and the cost function not only refers to the singularity but also considers the sampling period. Moreover, the feasibility of the MPC scheme and the mean square admissibility of the closed-loop system are deeply discussed by using the invariant ellipsoid. Finally, a numerical example is given to illustrate the main results

Perfluorocarbon restrains inflammation and cell apoptosis in rats with lung ischemia reperfusion injury via down regulation of TLR4/NF κB signaling pathway

Purpose: To exaluate the effect of perfluorocarbon on lung ischemia-reperfusion injury in rats, and to unravel the potential underlying mechanism.Methods: A total of 36 Sprague-Dawley (SD) rats were randomly assigned to sham group, model group, and perfluorocarbon group (12 rats per group). The levels of inflammatory factors (TNF-α and IL1β) were determined using enzyme-linked immunosorbent assay (ELISA). Cell apoptosis was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, while Western blotting was conducted to determine the protein expressions of TLR4 and NF-κB.Results: The levels of inflammatory factors in the model and perfluorocarbon groups were significantly higher than those in operation group (p < 0.05), while their levels in perfluorocarbon group were significantly lower than in model group (p < 0.05). The mRNA expression levels of TNF-α and IL-1β in lung tissues rose significantly in both model and perfluorocarbon groups when compared with those in sham group (p < 0.05), but declined significantly in the perfluorocarbon group in comparison with those in model group (p < 0.05). Furthermore, the perfluorocarbon group exhibited a significantly lower cell apoptosis than model group (p < 0.05). The relative protein expression levels of TLR4 and NF-κBdeclined significantly in perfluorocarbon group than in model group.Conclusions: Perfluorocarbon down-regulates the TLR4/NF-κB signaling pathway, and inhibits inflammation a

PET study of sphingosine-1-phosphate receptor 1 expression in response to S. aureus infection

Sphingosine-1-phosphate receptor 1 (S1PR1) plays a crucial role in infectious diseases. Targeting S1PR1 provides protection against pathogens, such as influenza viruses. This study is aimed at investigating S1PR1 in response to bacterial infection by assessing S1PR1 expression i

Biodistribution in sarcoma 180-bearing mice of N-succinyl-chitosan nanoparticles for tumor targeting

In the present study, we sought to systemically evaluate the biodistribution and the tumor-accumulation of N-succinyl-chitosan nanoparticles (Suc-Chi-NPs, 200 nm in diameter) in model tumor-bearing mice and also the binding of Suc-Chi-NPs to k562 cells was evaluated by flow cytometry. In vitro studies showed that all Suc-Chi-NPs displayed high affinity to k562 cells. After intravenous injection of Suc- Chi-NPs via the tail vein, a small amount of Suc-Chi-NPs was found in liver and spleen for 4 days, whereas a negligible quantity was detected in heart and lung. The distributed amount of Suc-Chi-NPs in blood was as a high level throughout the 4 days. The distributed amount of Suc-Chi-NPs (> 15 % of dose) was accumulated at 1 day and gradually increased in tumor, as blood circulation time increased. This result suggests that Suc-Chi-NPs accumulate passively in the tumor tissue due to the enhanced permeability and retention (EPR) effect, following intravenous administration. These findings revealed the promising potential of Suc-Chi-NPs on the basis of Suc-Chi as a carrier for cancer therapy.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Nano-engineering of electron correlation in oxide superlattices

This Accepted Manuscript will be available for reuse under a CC BY-NC-ND 3.0 license after a 12 month embargo period. The published version can found here: https//dx.doi.org/10.1088/2399-1984/aa8f39Oxide heterostructures and superlattices have attracted a great deal of attention in recent years owing to the rich exotic properties encountered at their interfaces. We focus on the potential of tunable correlated oxides by investigating the spectral function of the prototypical correlated metal SrVO<sub>3</sub>, using soft x-ray absorption spectroscopy (XAS) and resonant inelastic soft x-ray scattering (RIXS) to access both unoccupied and occupied electronic states, respectively. We demonstrate a remarkable level of tunability in the spectral function of SrVO<sub>3</sub> by varying its thickness within the SrVO<sub>3</sub>/SrTiO<sub>3</sub> superlattice, showing that the effects of electron correlation can be tuned from dominating the energy spectrum in a strongly correlated Mott-Hubbard insulator, towards a correlated metal. We show that the effects of dimensionality on the correlated properties of SrVO<sub>3</sub> are augmented by interlayer coupling, yielding a highly flexible correlated oxide that may be readily married with other oxide systems.2018-09-2