1,846 research outputs found
Empirical properties of inter-cancellation durations in the Chinese stock market
Order cancellation process plays a crucial role in the dynamics of price
formation in order-driven stock markets and is important in the construction
and validation of computational finance models. Based on the order flow data of
18 liquid stocks traded on the Shenzhen Stock Exchange in 2003, we investigate
the empirical statistical properties of inter-cancellation durations in units
of events defined as the waiting times between two consecutive cancellations.
The inter-cancellation durations for both buy and sell orders of all the stocks
favor a -exponential distribution when the maximum likelihood estimation
method is adopted; In contrast, both cancelled buy orders of 6 stocks and
cancelled sell orders of 3 stocks prefer Weibull distribution when the
nonlinear least-square estimation is used. Applying detrended fluctuation
analysis (DFA), centered detrending moving average (CDMA) and multifractal
detrended fluctuation analysis (MF-DFA) methods, we unveil that the
inter-cancellation duration time series process long memory and multifractal
nature for both buy and sell cancellations of all the stocks. Our findings show
that order cancellation processes exhibit long-range correlated bursty
behaviors and are thus not Poissonian.Comment: 14 pages, 7 figures and 5 table
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Eradication of unresectable liver metastasis through induction of tumour specific energy depletion.
Treatment of liver metastasis experiences slow progress owing to the severe side effects. In this study, we demonstrate a strategy capable of eliminating metastatic cancer cells in a selective manner. Nucleus-targeting W18O49 nanoparticles (WONPs) are conjugated to mitochondria-selective mesoporous silica nanoparticles (MSNs) containing photosensitizer (Ce6) through a Cathepsin B-cleavable peptide. In hepatocytes, upon the laser irradiation, the generated singlet oxygen species are consumed by WONPs, in turn leading to the loss of their photothermally heating capacity, thereby sparing hepatocyte from thermal damage induced by the laser illumination. By contrast, in cancer cells, the cleaved peptide linker allows WONPs and MSNs to respectively target nucleus and mitochondria, where the therapeutic powers could be unleashed, both photodynamically and photothermally. This ensures the energy production of cancer cells can be abolished. We further assess the underlying molecular mechanism at both gene and protein levels to better understand the therapeutic outcome
A numerically stable fragile watermarking scheme for authenticating 3D models
International audienceThis paper analyzes the numerically instable problem in the current 3D fragile watermarking schemes. Some existing fragile watermarking schemes apply the floating-point arithmetic to embed the watermarks. However, these schemes fail to work properly due to the numerically instable problem, which is common in the floating-point arithmetic. This paper proposes a numerically stable fragile watermarking scheme. The scheme views the mantissa part of the floating-point number as an unsigned integer and operates on it by the bit XOR operator. Since there is no numerical problem in the bit operation, this scheme is numerically stable. The scheme can control the watermark strength through changing the embedding parameters. This paper further discusses selecting appropriate embedding parameters to achieve good performance in terms of the perceptual invisibility and the ability to detect unauthorized attacks on the 3D models. The experimental results show that the proposed public scheme could detect attacks such as adding noise, adding/deleting faces, inserting/removing vertices, etc. The comparisons with the existing fragile schemes show that this scheme is easier to implement and use
A case of advanced mycosis fungoides with comprehensive skin and visceral organs metastasis: sensitive to chemical and biological therapy
AbstractMycosis fungoides is a common cutaneous T-cell lymphoma, which is usually characterized by chronic, indolence progression, with absence of typical symptoms in early stage, metastasis to lymph nodes, bone marrow and visceral organs in later stage and ultimately progression to systemic lymphoma. It can result in secondary skin infection which is a frequent cause of death. At present, no curative therapy existed. Therapeutic purpose is to induce remission, reduce tumor burden and protect immune function of patients. A case of patient with advanced severe mycosis fungoides receiving CHOP plus interferon α-2a was reported here, with disease-free survival of 7 months and overall survival of over 17.0 months, and current status as well as developments of mycosis fungoides were briefly introduced
An intrinsic link between long-term UV/optical variations and X-ray loudness in quasars
Observations have shown that UV/optical variation amplitude of quasars depend
on several physi- cal parameters including luminosity, Eddington ratio, and
likely also black hole mass. Identifying new factors which correlate with the
variation is essential to probe the underlying physical processes. Combining
~ten years long quasar light curves from SDSS stripe 82 and X-ray data from
Stripe 82X, we build a sample of X-ray detected quasars to investigate the
relation between UV/optical variation amplitude () and X-ray
loudness. We find that quasars with more intense X-ray radiation (com- pared to
bolometric luminosity) are more variable in UV/optical. Such correlation
remains highly significant after excluding the effect of other parameters
including luminosity, black hole mass, Ed- dington ratio, redshift, rest-frame
wavelength (i.e., through partial correlation analyses). We further find the
intrinsic link between X-ray loudness and UV/optical variation is gradually
more prominent on longer timescales (up to 10 years in the observed frame), but
tends to disappear at timescales < 100 days. This suggests a slow and long-term
underlying physical process. The X-ray reprocessing paradigm, in which
UV/optical variation is produced by a variable central X-ray emission
illuminating the accretion disk, is thus disfavored. The discovery points to an
interesting scheme that both the X-ray corona heating and UV/optical variation
is quasars are closely associated with magnetic disc turbulence, and the
innermost disc turbulence (where corona heating occurs) correlates with the
slow turbulence at larger radii (where UV/optical emission is produced).Comment: 9 pages, 4 figures, 1 table, accepted by Ap
Feasibility study on posterior laminar screw fixation techniques in the axis
AbstractObjectiveTo get morphologic parameters of Chinese adults through observation and measurement on axial laminas, to evaluate the feasibility of placing axial laminar screws and to introduce the technique.MethodsRelative parameters of 28 sets of fresh Chinese adults' axial specimens, including distance from the superior and inferior entry points of axial laminar screws to the superior margins of axial laminas, superior, middle, inferior thickness and height of the axial laminas, length and angle of the axial laminar screw trajectories, distance from the entry points of axial laminar screws to the transverse foramen and central points of the inferior articular process, were measured with a digital caliper and a goniometer. Data were statistically analyzed.ResultsAveragely, distance from the superior and inferior entry points of axial laminar screws to the superior margins of axial laminas was 5 mm and 9 mm, superior, middle, inferior thickness and the height of the axial laminas were 3.2 mm, 6.7 mm, 5.5 mm and 12.8 mm respectively, and the length of the superior and inferior axial laminar screw trajectories was 26.2 mm and 25.5 mm, respectively.ConclusionsIt is feasible and reliable to apply posterior laminar screw fixation techniques to the axes of Chinese adults. Also the C2 laminar screw fixation technique can be taken as a supplementary to conventional posterior screw fixations of C2
Flaw-driven Failure in Nanostructures
Understanding failure in nanomaterials is critical for the design of reliable structural materials and small-scale devices that have components or microstructural elements at the nanometer length scale. No consensus exists on the effect of flaws on fracture in bulk nanostructured materials or in nanostructures. Proposed theories include nanoscale flaw tolerance and maintaining macroscopic fracture relationships at the nanoscale with virtually no experimental support. We explore fracture mechanisms in nanomaterials via nanomechanical experiments on nanostructures with pre-fabricated surface flaws in combination with molecular dynamics simulations. Nanocrystalline Pt cylinders with diameters of ~120 nm with intentionally introduced surface notches were created using a template-assisted electroplating method and tested in uniaxial tension in in-situ SEM. Experiments demonstrate that 8 out of 12 samples failed at the notches and that tensile failure strengths were ~1.8 GPa regardless of whether failure occurred at or away from the flaw. These findings suggest that failure location was sensitive to the presence of flaws, while strength was flaw-insensitive. Molecular dynamics simulations support these observations and show that incipient plastic deformation commences via nucleation and motion of dislocations in concert with grain boundary sliding. We postulate that such local plasticity reduces stress concentration ahead of the flaw to levels comparable with the strengths of intrinsic microstructural features like grain boundary triple junctions, a phenomenon unique to nano-scale solids that contain an internal microstructural energy landscape. This mechanism causes failure to occur at the weakest link, be it an internal inhomogeneity or a surface feature with a high local stress
Extraordinary strain hardening from dislocation loops in defect-free Al nanocubes
The interaction of crystalline defects leads to strain hardening in bulk
metals. Metals with high stacking fault energy (SFE), such as aluminum, tend to
have low strain hardening rates due to an inability to form stacking faults and
deformation twins. Here, we use in situ SEM mechanical compressions to find
that colloidally synthesized defect-free 114 nm Al nanocubes combine a high
linear strain hardening rate of 4.1 GPa with a high strength of 1.1 GPa. These
nanocubes have a 3 nm self-passivating oxide layer that has a large influence
on mechanical behavior and the accumulation of dislocation structures.
Post-compression TEM imaging reveals stable prismatic dislocation loops and the
absence of stacking faults. MD simulations relate the formation of dislocation
loops and strain hardening to the surface oxide. These results indicate that
slight modifications to surface and interfacial properties can induce enormous
changes to mechanical properties in high SFE metals.Comment: 10 pages, 7 figure
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