Inwentarz karmelitów w Białyniczach z 1825 r. w zbiorach Biblioteki Litewskiej Akademii Nauk w Wilnie, fond 273–263, k. 1–8

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Międzynarodowa Konferencja Naukowa imienia Profesora Stanisława Czepity „O pojmowaniu prawa i prawoznawstwa”, Szczecin, 24–25 listopada 2022 r. i 27 stycznia 2023 r.

W dniach 24–25 listopada 2023 roku oraz 27 stycznia 2023 roku odbyła się Międzynarodowa Konferencja Naukowa O pojmowaniu prawa i prawoznawstwa, upamiętniająca prof. Stanisława Czepitę1, która została zorganizowana przez Wydział Prawa i Administracji Uniwersytetu Szczecińskiego w formule zdalnej. Patronat nad Konferencją objęli Rektor Uniwersytetu Szczecińskiego, Marszałek Województwa Zachodniopomorskiego oraz Prezydent Miasta Szczecin, a partnerami wydarzenia byli Okręgowa Rada Adwokacka w Szczecinie, Izba Komornicza w Szczecinie, Województwo Zachodniopomorskie, Kancelaria Komornika Sądowego Marcina Borka, Pallada Ubezpieczenia, Wydawnictwo C.H. Beck oraz Stowarzyszenie Amicus Facultatis Iuris Stetinensis

Synthetic Applications of Oxidative Aromatic Coupling : From Biphenols to Nanographenes

Oxidative aromatic coupling occupies a fundamental place in the modern chemistry of aromatic compounds. It is a method of choice for the assembly of large and bewildering architectures. Considerable effort was also devoted to applications of the Scholl reaction for the synthesis of chiral biphenols and natural products. The ability to form biaryl linkages without any prefunctionalization provides an efficient pathway to many complex structures. Although the chemistry of this process is only now becoming fully understood, this reaction continues to both fascinate and challenge researchers. This is especially true for heterocoupling, that is, oxidative aromatic coupling with the chemoselective formation of a C−C bond between two different arenes. Analysis of the progress achieved in this field since 2013 reveals that many groups have contributed by pushing the boundary of structural possibilities, expanding into surface‐assisted (cyclo)dehydrogenation, and developing new reagents

Matching CIE illuminants to measured spectral power distributions: A method to evaluate non-visual potential of daylight in two European cities

Abstract The evaluation of non-visual effects of light is a crucial topic in lighting design research and practice. Performing such analysis requires precise information about the spectral distribution of the tested light source. Assessing non-visual effects of daylight is complicated due to its spectral composition continuously changing, depending on many factors. Currently there are no available databases with spectral and spatial radiation patterns of the sky vault for locations spread all over the world, and an easy and common method to evaluate non-visual effects of daylight is lacking. The goal of the paper is to provide a simple method to evaluate the non-visual potential of daylight, accounting for its variability. In order to present it, spectral measurements were conducted in two European cities in spring and summer. Horizontal and vertical illuminance toward the four cardinal directions was measured. Daylight variability was analysed in terms of illuminance, Correlated Colour Temperature (CCT) and Melanopic to Photopic (M/P) ratio. A comparison between the measured spectra and the CIE standard illuminants was performed and it was found that the usefulness of this method to evaluate non-visual effects of light in terms of M/P is adequate and provides reliable results. Therefore, a simple method to estimate the non-visual potential of daylight based on the use of D series of illuminants was presented and validated by comparing the results with the measured data. Using this method to calculate M/P always achieves RMSPEs below 6%

Deuterium isotope effects on 13C chemical shifts of 10-Hydroxybenzo[h]quinolines

Deuterium isotope effects on 13C-NMR chemical shifts are investigated in a series of 10-hydroxybenzo[h]quinolines (HBQ’s) The OH proton is deuteriated. The isotope effects on 13C chemical shifts in these hydrogen bonded systems are rather unusual. The formal four-bond effects are found to be negative, indicating transmission via the hydrogen bond. In addition unusual long-range effects are seen. Structures, NMR chemical shifts and changes in nuclear shieldings upon deuteriation are calculated using DFT methods. Two-bond deuterium isotope effects on 13C chemical shifts are correlated with calculated OH stretching frequencies. Isotope effects on chemical shifts are calculated for systems with OH exchanged by OD. Hydrogen bond potentials are discussed. New and more soluble nitro derivatives are synthesized

Matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in the diagnosis of colorectal adenoma and cancer patients.

The aim of the study was to assess the importance of the measurement of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of matrix metalloproteinases 2 (TIMP-2) in patients with colorectal cancer (CRC) in relation to clinicopathological features of tumor and patients' survival. Additionally, we determined serum MMP-2 and TIMP-2 in colorectal adenoma (CA) patients and healthy controls and compared them with tumor markers, CEA and CA 19-9. The serum levels of MMP-2 and TIMP-2 in 91 CRC patients, 28 CA subjects and 91 healthy controls were determined by ELISA method, but concentrations of CEA and CA 19-9 using MEIA method. Nonparametric statistical analyses were used. Serum levels of MMP-2 and TIMP-2 were significantly lower in CRC patients than in healthy subjects and decreased with tumor stage. Additionally, MMP-2 concentrations were significantly lower in patients with CRC than in CA group. Diagnostic sensitivity of TIMP-2 (59%) was the highest among biomarkers tested and increased in combined use with CEA (79%). Moreover, the area under ROC curve (AUC) of TIMP-2 was larger than AUC of MMP-2 in differentiation between CRC and healthy subjects, but lower than AUC of matrix metalloproteinase 2 in differentiation between colorectal cancer and adenoma. Our findings suggest clinical usefulness of TIMP-2 as a biomarker in the diagnosis of CRC, especially in combination with CEA. However, further investigation is necessary

Excited-State Symmetry Breaking in an Aza-nanographene Dye

The photophysics of a structurally unique aza-analogue of polycyclic aromatic hydrocarbons characterized by 12 conjugated rings and a curved architecture is studied in detail. The combined experimental and computational investigation reveals that the lowest excited state has charge-transfer character in spite of the absence of any peripheral electron-withdrawing groups. The exceptionally electron-rich core comprised of two fused pyrrole rings is responsible for it. The observed strong solvatofluorochromism is related to symmetry breaking occurring in the emitting excited state, leading to a significant dipole moment (13.5 D) in the relaxed excited state. The anomalously small fluorescence anisotropy of this molecule, qualitatively different from what is observed in standard quadrupolar dyes, is explained as due to the presence of excited states being close in energy but having different polarization directions

Clinical significance of serum levels of matrix metalloproteinase 2 (MMP-2) and its tissue inhibitor (TIMP-2) in gastric cancer

Matrix metalloproteinase 2 (MMP-2) is able to degrade type IV collagen, and thus plays a key role in the migration of tumor cells. MMP-2 activity is inhibited by its tissue inhibitor (TIMP-2). The imbalance between MMPs and TIMPs may facilitate progression of cancer cells. The aim of this study was to compare the clinical importance of MMP-2 and TIMP-2 to that of classical tumor markers, namely carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) in the diagnosis of gastric cancer (GC) by calculating the diagnostic criteria and estimating the levels of MMP-2, TIMP-2, CEA and CA 19-9 in GC patients in relation to clinicopathological features of cancer. We found that serum levels of MMP-2 and TIMP-2 were significantly lower, whereas serum tumor markers were higher, in GC patients than in healthy subjects. Moreover, concentrations of TIMP-2 and CEA correlated with gastric wall infiltration, while CA 19-9 levels correlated with gastric wall infiltration and the presence of nodal metastasis. None of the proteins tested was found to be an independent prognostic factor for GC patients’ survival. The percentage of true positive results of TIMP-2 (61%) was higher than those of MMP-2 (54%) and the classical tumor markers CEA (21%) and CA 19-9 (31%). The highest diagnostic sensitivity was observed for the combined use of TIMP-2 with MMP-2 (77%). The results suggest the greater importance of serum MMP-2 and TIMP-2 than of the classical tumor markers CEA and CA 19-9 in the diagnosis of GC. But this issue requires further investigation. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 125–131