Oral lesions in HIV infected individuals from Ribeirão Preto, Brazil

Objectives: The aim of this study was to diagnosis oral lesions related to HIV infection in individuals followed in the General Hospital of the School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. The presence of oral lesions was correlated with gender, age, smoking habit, levels of CD4 lymphocytes, HIV load, time of HIV seropositivity, AIDS condition, use of removable dental prosthesis, and use of HAART. Materials and Methods: 340 HIV infected individuals were selected for this study, all participants of the study were examined by only one practiced dentist which performed anamnesis, peribuccal and oral examination. Results: Oral lesions were observed in 113 of 340 (33.2%) HIV infected individuals. These oral lesions included: oral candidiasis (17.7%) of pseudomembranous (10.8%) and of erythematous types (6.9%), angular cheilitis (13.9%), hairy leukoplakia (11.8%), and oral ulcers (2.1%). Oral candidiasis lesions were more frequently observed in women (p.033). Smoking addict participants presented a high frequency of tongue hairy leukoplakia (p.038) and a reduced frequency of oral ulcers (p.018). Hairy leukoplakia and pseudomembranous candidiasis were inversely correlated to CD4+L levels and directly correlated with HIV load, behaving as immune depression markers. Hairy leukoplakia and pseudomembranous candidiasis also showed an inverse correlation with HAART use (p<.0001). Patients using mobile dental prosthesis presented a high frequency of erythematous candidiasis (p.003). Conclusion: The inverse correlation with CD4+L level and the direct correlation with HIV load suggest that oral lesions could be used as alternative clinical markers for poor immune condition in HIV infected individuals

Análise do desempenho entre investimentos em Real Estate e Fundo de Investimento Imobiliário

TCC (graduação) - Universidade Federal de Santa Catarina. Centro Sócio-Econômico. Economia.Existe uma grande quantidade de investimentos disponíveis para quem deseja obter renda extra. Dentre os investimentos, os imobiliários merecem destaque especial, tendo em vista serem formas seguras de investimento, pois proporcionam boa rentabilidade e baixo risco. O objetivo geral do estudo é analisar o desempenho entre as aplicações financeiras em Real Estate e Fundos de Investimento Imobiliários (FIIs). A fim de se atingir o objetivo proposto, para análise do risco-retorno foram realizadas regressões do Modelo de Precificação de Ativos, além de modelos inspirados no mesmo para avaliação da performance, como, o índice de Sharpe, o índice de Treynor, o Alfa de Jensen e o índice de Modigliani e Modigliani. Os dados compreendem o período de fevereiro de 2012 a julho de 2019, e foram coletados dos sites da FIPE, B3 e do Governo federal. Ao final do estudo observou-se que o investimento em FIIs representado pelo índice IFIX se mostrou superior, revelando-se um investimento mais vantajoso que o investimento direto em imóveis, representados pelo índice FIPEZAP.There are a lot of investments available for those looking to earn extra income. Among the investments, Real Estate deserves special mention, considering they are safe forms of investment, as they provide good profitability and low risk. The general objective of the study is to analyze the performance between financial investments in real estate and Real Estate Investment Funds (FIIs). In order to achieve the proposed objective, regressions of the Asset Pricing Model were carried out to analyze the risk-return, in addition to models inspired by the same for performance evaluation, such as, the Sharpe Ratio, the Treynor Ratio, the Jensen alpha and the Modigliani and Modigliani index. The data cover the period from February 2012 to July 2019, and were collected from the FIPE, B3 and Federal Government websites. At the end of the study, it was observed that investment in FIIs represented by the IFIX index proved to be superior, proving to be a more advantageous investment than direct investment in Real Estate, represented by the FIPEZAP index

Oral Candida spp carriage and periodontal diseases in HIV-infected patients in Ribeirão Preto, Brazil

The majority of HIV-infected patients develop Candida spp-associated clinical oral lesions. Studies have shown that asymptomatic oral colonization of Candida spp may lead to oral lesions or become a source of disseminated infections. The aim of this study was to verify the effects of periodontal conditions on Candida spp prevalence and Candida spp carriage in the oral cavity of HIV-infected patients compared to non-infected patients. Twenty-five patients not infected with HIV and 48 HIV-infected patients were classified according to periodontal conditions as being periodontal healthy or with periodontal disease. Candida spp carriage and classification were performed in oral rinse samples. Viral load and CD4+ T lymphocyte (CD4+L) counts were performed in blood samples from HIV-infected patients. No differences in Candida spp prevalence related to HIV status or periodontal condition were detected. However, Candida spp carriage was increased in periodontally affected HIV-infected patients when compared to periodontally healthy HIV-infected patients (p= 0.04). Periodontally healthy HIV-infected patients presented Candida spp carriage in similar levels as healthy or periodontally affected non-HIV-infected patients. Candida spp carriage was correlated with CD4+L counting in HIV-infected patients. We concluded that periodontal disease is associated with increased Candida spp carriage in HIV-infected patients and may be a predisposing factor to clinical manifestations of candidiasis

Chapuis Jean et Hervé Rivière, Wayana eitoponpë. (Une) Histoire (orale) des Indiens Wayana

Ce monumental ouvrage de plus de mille pages, illustré de nombreuses photographies et enrichi par quatre annexes et trois index, se présente en deux parties. La première se réfère à l’ethnohistoire ou, plutôt, à l’auto-histoire des Wayana, les analyses portant sur 51 récits collectés en Guyane française par Jean Chapuis au cours de ses différents séjours sur le terrain entre 1992 et 1998. La deuxième, nettement plus courte, porte sur le kalawu, une série de chants anciens associés au rituel d..

De la producción a la utilización de resultados de investigación en la práctica asistencial: una experiencia en consolidación

Embora desejável, nem sempre os profissionais estão preparados para consumir resultados de pesquisa. Este artigo busca apresentar o processo de desenvolvimento e implantação de inovações, baseado no modelo de Rogers, por meio de estratégias para preparar o enfermeiro para utilizar as melhores evidências para uma prática clínica de qualidade. Trata-se de uma parceria entre uma instituição de ensino e uma de assistência hospitalar. A partir da identificação de problemas oriundos das áreas de atuação dos enfermeiros da instituição de saúde, foram desenvolvidos projetos de pesquisas para a busca de evidências e testes de intervenções. Os resultados dessa experiência evidenciaram a viabilidade do uso do modelo apresentado como referencial metodológico, contribuindo para alcance das metas da instituição.Although it is desirable that professionals use research results, often they are not prepared for that. This article aims to present the process of development and establishment of innovations, based on Rogers' model, through strategies to train nurses to use the best evidences for a quality clinical practice. It is a partnership between a educational institution and a hospital care institution. Following identification of problems from nurses' own practice in a health institution research proposals were developed to search for evidences and to test interventions. Results of this experience evidenced the viability of use of a model presented as a methodological framework what contributed to reach the institutions' goal.Aún sea deseable, ni siempre los profesionales están preparados para utilizar resultados de investigación. Este artículo objetiva presentar el proceso de desarrollo y implementación de innovaciones, basado en el modelo de Rogers, por medio de estrategias para preparar el enfermero para utilizar las mejores evidencias para una práctica clínica de calidad. Se trata de una asociación entre una institución de enseñanza y una de atención hospitalaria. A partir de la identificación de problemas oriundos de las áreas de actuación de los enfermeros participantes del proyecto (n=28), fue consensuado el desarrollo de 18 proyectos de investigación. Los resultados de este experimento demostró la viabilidad de utilizar el modelo que se presenta como un modelo metodológico, lo que contribuye al logro de los objetivos de la institución

COMPETIÇÃO EM Drosophila. I. D. hydei VERSUS D. immigrans

Comparações na aptidão competitiva de D. hydei e D. immigrans foram realizadas em populações intraespecíficas (unitárias) e em populações interespecíficas (mistas), mantidas pela técnica da transferência seriada. Drosophila hydei foi a espécie que apresentou maior número de moscas durante todo o período experimental, este fato foi devido ao seu melhor desempenho nas populações unitárias. Nas populações mistas, D. immigrans teve maior aptidão competitiva relativa, influenciada pela superior emergência de imagos, e o seu número de indivíduos foi igual ao de D. hydei. Deste modo, as duas espécies diferiram em suas habilidades competitivas, D. hydei foi melhor competidora na fase adulta e D. immigrans, nos estados imaturos da espécie. Assim, nas condições testadas, a exploração diferencial dos recursos disponíveis e diferenças na aptidão competitiva entre estados imaturos e adultos foram as principais causas da coexistência destas duas espécies em laboratório, durante todo o período experimental. Neste caso, os resultados mostram a desqualificação do princípio da exclusão competitiva, ou princípio de Gause

Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex.

Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host's immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as 'key players' within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD