23 research outputs found
A Catalog of Reference Genomes from the Human Microbiome
The human microbiome refers to the community of microorganisms including prokaryotes, viruses
and microbial eukaryotes that populate the human body. The National Institutes of Health launched
an initiative that focuses describing the diversity of microbial species associated with health and
disease. The first phase of this initiative includes the sequencing of hundreds of microbial reference
genomes, coupled to metagenomic sequencing from multiple body sites. Here we present results
from an initial reference genome sequencing of 178 microbial genomes. From 547,968 predicted
polypeptides that correspond to the gene complement of these strains “novel” polypeptides that had
both unmasked sequence length > 100 amino acids and no BLASTP match to any non-reference
entry in the nr subset were defined. This analysis resulted in a set of 30,867 polypeptides, of which
29,987 (~97%) were unique. In addition, this set of microbial genomes allows for ~ 40% of random
sequences from the microbiome of the gastrointestinal tract to be associated with organisms based
on the match criteria used. Insights into pan-genome analysis suggest that we are still far from
saturating microbial species genetic datasets. In addition, the associated metrics and standards used
by the group for quality assurance are presented
The archaeology of the military orders: the material culture of holy war
This paper reviews the current state of research into the archaeology of the military orders. It contrasts the advances made by historians and archaeologists, with the latter continuing to focus on the particularism of individual sites, with an emphasis on architectural analyses. Historians have contributed new insights by adopting a supranational approach. This paper argues that archaeologists can build on this by adopting a more problem-oriented, comparative approach. Drawing on examples from frontier and heartland territories, archaeological approaches are subdivided into material investment, material identity and cultural landscapes, to place sites of the military orders within a long-term, multi-scalar contexts. This contributes to a broader social and economic understanding of the orders, who contributed significantly to urbanisation, rural development and trade, and invested in material expressions of their authority and ideology. The paper concludes that more holistic, inter-regional approaches will move the archaeological study of the military orders forward
Parerga. Frames of Art/Institutional Critique (within Dissent and Certainty)
Events/Projects by Vlad Morariu: Theory Fellow 10/2013 - 06/2014
[PARERGA] FRAMES OF ART / INSTITUTIONAL CRITIQUE
Fokus Grupa, Freee Art Collective, Mihaela Brebenel and Vlad Morariu
An Intervention within 'Dissent and Certainty', Kunstpavillon Innsbruck
12.06.2014 - 26.07.2014
Daylight Perspectives on 'Dissent and Certainty'. Timelapse: Daniel Jarosch & Patrick Ausserdorfer
Music: exert from “ a recipe for concentrated dark matter” by Christoph Fugenschuh
Shot on July 6th 2014 6:30 am to 10.30 pm at Kunstpavillon Innsbruck for the international fellowship program for art and theory www.buchsenhausen.at
Dissent and Certainty
12.06. – 26.07.2014, KUNSTPAVILLON
Sezgin Boynik, Fokus Grupa, Freee Art Collective, Petra Gerschner, Vlad Morariu, Cathleen Schuster & Marcel Dickhage
Concluding exhibition curated by Andrei Siclod
Risk Nomogram Does Not Predict Anastomotic Leakage After Colon Surgery Accurately: Results of the Multi-center LekCheck Study
Purpose Anastomotic leakage (AL) is a dreaded complication after colorectal surgery. Preoperatively identifying high-risk patients can help to reduce the incidence of this complication. For this reason, AL risk nomograms have been developed. The objective of this study was to test the AL risk nomogram developed by Frasson, et al. for validity and to identify risk-factors for AL. Methods From the international multi-center LekCheck study database, patients who underwent colonic surgery with the formation of an anastomosis were included. Data were prospectively collected between 2016 and 2019 at 14 hospitals. Univariate and multivariable regression analyses, and area under receiver operating characteristic curve analysis (AUROC) were performed. Results A total of 643 patients were included. The median age was 70 years and 51% were male. The majority underwent surgery for malignancies (80.7%). The overall AL rate was 9.2%. The risk nomogram was not predictive for AL in the population tested (AUROC 0.572). Low preoperative haemoglobin (p = 0.006), intraoperative hypothermia (p = 0.02), contamination of the operative field (p = 0.004), and use of epidural analgesia (p = 0.02) were independent risk-factors for AL. Conclusion The AL risk nomogram could not be validated using the international LekCheck study database. In the future, intraoperative predictive factors for AL, as identified in this study, should also be included in AL risk predictors.Radiolog
Risk Nomogram Does Not Predict Anastomotic Leakage After Colon Surgery Accurately: Results of the Multi-center LekCheck Study
Purpose Anastomotic leakage (AL) is a dreaded complication after colorectal surgery. Preoperatively identifying high-risk patients can help to reduce the incidence of this complication. For this reason, AL risk nomograms have been developed. The objective of this study was to test the AL risk nomogram developed by Frasson, et al. for validity and to identify risk-factors for AL. Methods From the international multi-center LekCheck study database, patients who underwent colonic surgery with the formation of an anastomosis were included. Data were prospectively collected between 2016 and 2019 at 14 hospitals. Univariate and multivariable regression analyses, and area under receiver operating characteristic curve analysis (AUROC) were performed. Results A total of 643 patients were included. The median age was 70 years and 51% were male. The majority underwent surgery for malignancies (80.7%). The overall AL rate was 9.2%. The risk nomogram was not predictive for AL in the population tested (AUROC 0.572). Low preoperative haemoglobin (p = 0.006), intraoperative hypothermia (p = 0.02), contamination of the operative field (p = 0.004), and use of epidural analgesia (p = 0.02) were independent risk-factors for AL. Conclusion The AL risk nomogram could not be validated using the international LekCheck study database. In the future, intraoperative predictive factors for AL, as identified in this study, should also be included in AL risk predictors
Risk Nomogram Does Not Predict Anastomotic Leakage After Colon Surgery Accurately: Results of the Multi-center LekCheck Study
Purpose: Anastomotic leakage (AL) is a dreaded complication after colorectal surgery. Preoperatively identifying high-risk patients can help to reduce the incidence of this complication. For this reason, AL risk nomograms have been developed. The objective of this study was to test the AL risk nomogram developed by Frasson, et al. for validity and to identify risk-factors for AL. Methods: From the international multi-center LekCheck study database, patients who underwent colonic surgery with the formation of an anastomosis were included. Data were prospectively collected between 2016 and 2019 at 14 hospitals. Univariate and multivariable regression analyses, and area under receiver operating characteristic curve analysis (AUROC) were performed. Results: A total of 643 patients were included. The median age was 70 years and 51% were male. The majority underwent surgery for malignancies (80.7%). The overall AL rate was 9.2%. The risk nomogram was not predictive for AL in the population tested (AUROC 0.572). Low preoperative haemoglobin (p = 0.006), intraoperative hypothermia (p = 0.02), contamination of the operative field (p = 0.004), and use of epidural analgesia (p = 0.02) were independent risk-factors for AL. Conclusion: The AL risk nomogram could not be validated using the international LekCheck study database. In the future, intraoperative predictive factors for AL, as identified in this study, should also be included in AL risk predictors