34 research outputs found
CYTOGENETICS MIGHT ELUCIDATE THE ETIOLOGY OF ACUTE TRANSFORMATION OF CHRONIC MYELOPROLIFERATIVE SYNDROMES WITHOUT A PHILADELPHIA CHROMOSOME
Forty-four cases of childhood myelodysplasia with cytogenetics, documented by the Groupe Français de Cytogénétique Hématologique
Forty-four cases of myelodysplasia in children were studied. A third of the cases were unclassifiable according to the FAB system, Twenty-five cases were 'idiopathic' myelodysplastic syndromes (MDS), lour were secondary to chemo- and/or radiotherapy, and 15 (1/3) were found associated with a congenital genetic disease (such as familial myelodysplasia, chromosome syndrome, or various dysmorphic features). Polyclonality was retained in some cases, even in the 'idiopathic MDS' group, demonstrating that non-malignant myelodysplasia does exist. Sex ratio was well balanced in this study; mean age at diagnosis was 4 years; median survival was 3 years; prognosis was better in girls and in young children; normal karyotypes were associated with a better outcome, monosomy 7 with intermediate survival, and other chromosomal findings, including trisomy 8 and 19, with a worse prognosis; refractory anaemia with excess of blasts in transformation, and cases of. secondary MDS were associated with a bad prognosis. Childhood MDS are extremely heterogeneous conditions deserving more studies
Acute nonlymphocytic leukemia (ANLL) with isochromosome i(17q) as the sole chromosomal anomaly: a distinct entity?
Treatment and outcome of Philadelphia chromosome-positive acute lymphoblastic leukemia in adults after relapse
Diffuse pattern of bone marrow involvement on magnetic resonance imaging is associated with high risk cytogenetics and poor outcome in newly diagnosed, symptomatic patients with multiple myeloma: A single center experience on 228 patients
Hypodiploidy is a major prognostic factor in multiple myeloma.
Conventional karyotypes performed before any treatment in 208 patients with multiple myeloma were reviewed by the Groupe Français de Cytogénétique Hématologique. A total of 138 patients displayed complex chromosomal abnormalities (CCAs). According to the chromosome number pattern, a first group of 75 patients had a hyperdiploid karyotype. A second group of 63 patients referred to as the hypodiploid group had either pseudodiploid, hypodiploid, or near-tetraploid karyotypes. Of 159 treated patients available for survival analysis, 116 had an abnormal karyotype. The comparison of overall survival (OS) between hyperdiploid and hypodiploid patients showed a highly significant difference (median OS 33.8 vs 12.6 months, respectively, P <.001). The presence of 14q32 rearrangements (36 of 116 patients) worsened the prognosis (median OS 17.6 vs 29.9 months, P <.02). The presence of chromosome 13q abnormalities (13qA, 63 patients) did not modify OS in CCA patients (median OS 20.6 vs 27.8 months, P <.59). However, taking into account the whole series including normal karyotypes, 13qA (63 of 159 patients) had a significant impact on OS (median 20.6 vs 37.1 months, P <.04). In the same way, the presence of a hypodiploid karyotype (52 of 159 patients) had a strong prognostic value (OS 12.8 vs 44.5 months, P <.000 01). A multivariate analysis including stage, beta2-microglobulin, bone marrow plasmocytosis, treatment type, 13qA, and hyperdiploidy and hypodiploidy showed that a hypodiploid karyotype was the first independent factor for OS (P <.001), followed by treatment approach. These results confirm that the chromosome number pattern of malignant plasma cells is a very powerful prognostic factor in newly diagnosed multiple myeloma patients