Molecular hydrogen as baryonic dark matter

High-angular resolution CO observations of small-area molecular structures (SAMS) are presented. The feature-less structures seen in the single-dish measurements break up into several smaller clumps in the interferometer map. At an adopted distance of 100pc their sizes are of order a few hundred AU, some of which are still unresolved at an angular resolution of about 3". The clumps have a fractal structure with a fractal index between 1.7 and 2.0. Their kinetic temperature is between 7K and 18K. Adopting standard conversion factors masses are about 1/10 Jupiter-masses for individual clumps and densities are higher than 20000cm^{-3}. The clumps are highly overpressured and it is unknown what creates or maintains such structures.Comment: 8 pages, 1 figure, accepted by Astrophysical Journal Letter

Reversal of migration flows: a fresh look at the German reunification

We investigate the dynamic effects of interregional labor market integration on migration flows, capital formation, and the price for housing services. The co-evolution of these variables depends on initial conditions at the time of labor market integration. In an initially capital-poor economy, there may be a reversal of migration flows during the transition to the steady state, while housing costs are increasing over time. Although capital may accumulate while labor emigrates early in the transition, the causal effect of immigration on capital investments and housing costs is positive. We present new data on the evolution of net migration flows and rental rates for housing in East Germany after 1990. Our results are consistent with the presented evidence in the reverse migration scenario

Landau functions for non-interacting bosons

We discuss the statistics of Bose-Einstein condensation (BEC) in a canonical ensemble of N non-interacting bosons in terms of a Landau function L_N^{BEC} (q) defined by the logarithm of the probability distribution of the order parameter q for BEC. We also discuss the corresponding Landau function for spontaneous symmetry breaking (SSB), which for finite N should be distinguished from L_N^{BEC}. Only for intinite N BEC and SSB can be described by the same Landau function which depends on the dimensionality and on the form of the external potential in a surprisingly complex manner. For bosons confined by a three-dimensional harmonic trap the Landau function exhibits the usual behavior expected for continuous phase transitions.Comment: 4 pages, 4 figures; final version to appear as a rapid communication in Physical Review A. Abstract modified and typos correcte

»Pakt für den Euro«: Kann mit dem Maßnahmenpaket die Europäische Union die Euro-Schuldenkrise überwinden?

ein Maßnahmenpaket zur Überwindung der Euro-Schuldenkrise geeinigt. Georg Milbradt, TU Dresden, ist der Ansicht, dass die verabredeten Maßnahmen die Probleme in der Eurozone nicht lösen werden. Zwar knüpfen die Vorschläge an wichtige Probleme an, wie z.B. Schuldenstand, private Verschuldung etc., sie unterliegen aber weiter einem politischen Verfahren mit den bekannten Schwächen. Von einer wirklichen Stabilisierung des Euroraums könne nicht gesprochen werden. Joachim Starbatty, Aktionsgemeinschaft Soziale Marktwirtschaft, sieht den permanenten Rettungsschirm als »eine weitere Etappe auf einer sich weiter drehenden Interventionsspirale« an. Andreas Haufler, Universität München, sieht in einer Festlegung auf das Ziel, kurzfristige Finanzmarktkrisen zu verhindern, das Risiko einer schleichenden Umwandlung des temporären Hilfsmechanismus in akuten Krisensituationen in eine Dauerfinanzierung hoch verschuldeter Mitgliedstaaten. Nach Meinung von Volker Grossmann, Universität Freiburg/Schweiz, gefährdet erst der Rettungsfonds den Euro, aufgrund der enormen Risiken für die Geberländer. Markus Ferber, Europäisches Parlament, erwartet von den Be - schlüssen die Erhöhung des Drucks auf finanzschwache Eurostaaten, ihre Haushalte zu konsolidieren und wieder wettbewerbsfähig zu werden. Insgesamt seien die Beschlüsse ein wichtiges stabilisierendes Signal an die weltweiten Finanzmärkte. Lüder Gerken, Stiftung Ordnungspolitik und Centrum für Europäi - sche Politik, Freiburg, sieht in den Vereinbarungen keine Lösung der Probleme der Eurozone. Im Gegenteil: Mit ihnen sei die letzte Gelegenheit versäumt worden, die Abschaffung des Bail-out-Verbots an rigide realwirtschaftliche Reformprogramme für die maroden Volkswirtschaften vor allem Südeuropas zu koppeln. Damit rücke die Anpassung dieser Volkswirtschaften in weite Ferne.Euro Währungskrise Schulden EU-Stabilitätspakt Konjunkturpolitik Europäische Wirtschafts- und Währungsunion

Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease

Mutations in PRKN cause the second most common genetic form of Parkinson's disease (PD)—a debilitating movement disorder that is on the rise due to population aging in the industrial world. PRKN codes for an E3 ubiquitin ligase that has been well established as a key regulator of mitophagy. Together with PTEN-induced kinase 1 (PINK1), Parkin controls the lysosomal degradation of depolarized mitochondria. But Parkin's functions go well beyond mitochondrial clearance: the versatile protein is involved in mitochondria-derived vesicle formation, cellular metabolism, calcium homeostasis, mitochondrial DNA maintenance, mitochondrial biogenesis, and apoptosis induction. Moreover, Parkin can act as a modulator of different inflammatory pathways. In the current review, we summarize the latest literature concerning the diverse roles of Parkin in maintaining a healthy mitochondrial pool. Moreover, we discuss how these recent discoveries may translate into personalized therapeutic approaches not only for PRKN-PD patients but also for a subset of idiopathic cases

Male-female communication triggers calcium signatures during fertilization in Arabidopsis

Cell-cell communication and interaction is critical during fertilization and triggers free cytosolic calcium ([Ca2+](cyto)) as a key signal for egg activation and a polyspermy block in animal oocytes. Fertilization in flowering plants is more complex, involving interaction of a pollen tube with egg adjoining synergid cells, culminating in release of two sperm cells and their fusion with the egg and central cell, respectively. Here, we report the occurrence and role of [Ca2+](cyto) signals during the entire double fertilization process in Arabidopsis. [Ca2+](cyto) oscillations are initiated in synergid cells after physical contact with the pollen tube apex. In egg and central cells, a short [Ca2+](cyto) transient is associated with pollen tube burst and sperm cell arrival. A second extended [Ca2+](cyto) transient solely in the egg cell is correlated with successful fertilization. Thus, each female cell type involved in double fertilization displays a characteristic [Ca2+](cyto) signature differing by timing and behaviour from [Ca2+](cyto) waves reported in mammals

Male-female communication triggers calcium signatures during fertilization in Arabidopsis

Cell-cell communication and interaction is critical during fertilization and triggers free cytosolic calcium ([Ca2+](cyto)) as a key signal for egg activation and a polyspermy block in animal oocytes. Fertilization in flowering plants is more complex, involving interaction of a pollen tube with egg adjoining synergid cells, culminating in release of two sperm cells and their fusion with the egg and central cell, respectively. Here, we report the occurrence and role of [Ca2+](cyto) signals during the entire double fertilization process in Arabidopsis. [Ca2+](cyto) oscillations are initiated in synergid cells after physical contact with the pollen tube apex. In egg and central cells, a short [Ca2+](cyto) transient is associated with pollen tube burst and sperm cell arrival. A second extended [Ca2+](cyto) transient solely in the egg cell is correlated with successful fertilization. Thus, each female cell type involved in double fertilization displays a characteristic [Ca2+](cyto) signature differing by timing and behaviour from [Ca2+](cyto) waves reported in mammals

Evidence of convective transport in tropical West Pacific region during SHIVA experiment

Air masses in the convective outflows of four large convective systems near Borneo Island in Malaysia were sampled in the height range 11–13 km within the frame of the SHIVA (Stratospheric Ozone: Halogen Impacts in a Varying Atmosphere) FP7 European project in November and December 2011. Correlated enhancements of CO, CH4 and the short-lived halogen species (CH3I and CHBr3) were detected when the aircraft crossed the anvils of the four systems. These enhancements were interpreted as the fingerprint of vertical transport from the boundary layer by the convective updraft and then horizontal advection in the outflow. For the four observations, the fraction f of air from the boundary layer ranged between 15 and 67%, showing the variability in transport efficiency depending on the dynamics of the convective system

Blood Omega-3 Fatty Acids Are Inversely Associated With Albumin-Creatinine Ratio in Young and Healthy Adults (The Omega-Kid Study).

Background: Omega-3 fatty acids are associated with a lower risk of cardiovascular disease (CVD) and with beneficial effects on CV risk factors. The albumin-creatinine ratio (ACR) is a risk factor for CVD, all-cause mortality and accelerated glomerular filtration rate (GFR) decline in the general population. We aimed to investigate the association between n-3 PUFAS and ACR in heathy individuals with preserved GFR. Design and Methods: The present cross-sectional analysis is part of the GAPP study, a population-based cohort of healthy adults aged 25-41 years. Individuals with known CVD, diabetes, or a BMI >35 kg/m2 were excluded. eGFR was calculated according to the combined Creatinine/Cystatin C CKD-EPI formula. ACR was obtained from a fasting morning urine sample. The Omega-3 Index (relative amount of EPA and DHA of total fatty acids in %) was obtained from whole blood aliquots. Results: Overall, 2001 participants (median age 37 years IQR 31; 40, 53% female) were included in this analysis. Median Omega-3 Index was 4.59 (IQR 4.06; 5.25) and median eGFR 111 ml/min/1.73 m2 (IQR 103; 118). Median ACR was 0.14 mg/mmol (IQR 0; 0.43). We found a significant inverse association of the Omega-3 Index with ACR (ratio 0.84, 95%CI 0.73-0.96; p = 0.011) which remained after comprehensive adjustment (ratio 0.86, 95%CI 0.74-1.00; p = 0.048). No association of the Omega-3 Index with eGFR was found. The adjusted difference in eGFR per 1-unit increase in Omega3-Index was -0.21 (95%CI -0.76; 0.35; p = 0.47). Conclusions: A higher Omega-3 Index was significantly associated with lower ACR in this young and healthy population with preserved eGFR. Omega-3 fatty acids may exhibit cardio- and nephroprotective effects in healthy individuals through modulation of ACR

Transurethral injection of autologous muscle precursor cells for treatment of female stress urinary incontinence: a prospective phase I clinical trial

INTRODUCTION AND HYPOTHESIS The purpose was to investigate the safety and feasibility of transurethral injections of autologous muscle precursor cells (MPCs) into the external urinary sphincter (EUS) to treat stress urinary incontinence (SUI) in female patients. METHODS Prospective and randomised phase I clinical trial. Standardised 1-h pad test, International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI-SF), urodynamic study, and MRI of the pelvis were performed at baseline and 6 months after treatment. MPCs gained through open muscle biopsy were transported to a GMP facility for processing and cell expansion. The final product was injected into the EUS via a transurethral ultrasound-guided route. Primary outcomes were defined as any adverse events (AEs) during follow-up. Secondary outcomes were functional, questionnaire, and radiological results. RESULTS Ten female patients with SUI grades I-II were included in the study and 9 received treatment. Out of 8 AEs, 3 (37.5%) were potentially related to treatment and treated conservatively: 1 urinary tract infection healed with antibiotics treatment, 1 dysuria and 1 discomfort at biopsy site. Functional urethral length under stress was 25 mm at baseline compared with 30 mm at 6 months' follow-up (p=0.009). ICIQ-UI-SF scores improved from 7 points at baseline to 4 points at follow-up (p=0.035). MRI of the pelvis revealed no evidence of tumour or necrosis, whereas the diameter of the EUS muscle increased from 1.8 mm at baseline to 1.9 mm at follow-up (p=0.009). CONCLUSION Transurethral injections of autologous MPCs into the EUS for treatment of SUI in female patients can be regarded as safe and feasible. Only a minimal number of expected and easily treatable AEs were documented