Opipramol inhibits lipolysis in human adipocytes without altering glucose uptake and differently from antipsychotic and antidepressant drugs with adverse effects on body weight control

Treatment with several antipsychotic drugs exhibits a tendency to induce weight gain and diabetic complications. The proposed mechanisms by which the atypical antipsychotic drug olanzapine increases body weight include central dysregulations leading to hyperphagia and direct peripheral impairment of fat cell lipolysis. Several investigations have reproduced in vitro direct actions of antipsychotics on rodent adipocytes, cultured preadipocytes, or human adipose tissue-derived stem cells. However, to our knowledge, no such direct action has been described in human mature adipocytes. The aim of the present study was to compare in human adipocytes the putative direct alterations of lipolysis by antipsychotics (haloperidol, olanzapine, ziprazidone, risperidone), antidepressants (pargyline, phenelzine), or anxiolytics (opipramol). Lipolytic responses to the tested drugs, and to recognized lipolytic (e.g., isoprenaline) or antilipolytic agents (e.g., insulin) were determined, together with glucose transport and amine oxidase activities in abdominal subcutaneous adipocytes from individuals undergoing plastic surgery. None of the tested drugs were lipolytic. Surprisingly, only opipramol exhibited substantial antilipolytic properties in the micromolar to millimolar range. An opipramol antilipolytic effect was evident against isoprenaline-, forskolin-, or atrial natriuretic peptide-stimulated lipolysis. Opipramol did not impair insulin activation of glucose transport but inhibited monoamine oxidase (MAO) activity to the same extent as antidepressants recognized as MAO inhibitors (pargyline, harmine, or phenelzine), whereas antipsychotics were inefficient. Considering its unique properties, opipramol, which is not associated with weight gain in treated patients, is a good candidate for drug repurposing because it limits exaggerated lipolysis, prevents hydrogen peroxide release by amine oxidases in adipocytes, and is thereby of potential use to limit lipotoxicity and oxidative stress, two deleterious complications of diabetes and obesity

Історія радянської України в бібліографічних покажчиках англомовних праць другої половини ХХ століття

У статті проаналізовано бібліографічні покажчики англомовної слов’янознавчої та радянознавчої літератури, видрукувані в англомовних країнах протягом другої половини ХХ ст. Зроблено спробу визначити місце, яке у них займали праці з історії України, зокрема ті, що стосуватися пізньосталінського та хрущовського періодів.В статье анализируются библиографические указатели англоязычной славяноведческой и советологической литературы, опубликованные в англоязычных странах во второй половине ХХ века. Сделана попытка охарактеризовать положение, которое в них занимала история Советской Украины, особенно ее позднесталинский и хрущевский периоды.In the article, the bibliographic guides to the English-language publications in Slavic, East European and Soviet Studies that were published in the second half of the 20th century are analyzed. The special attention is given to history of Ukraine from the second half of the 1940s till the mid-1960s as a particular subject in those guides

Toxicite, par ingestion forcee, de differents pesticides pour la Perdrix giise, Perdix perdix L., et la Perdrix rouge, Alectoris rufa L.

National audienc

Effets des fongicides sur la biotransformation hepatique et intestinale chez la Caille japonaise

National audienc

Effet des inscticides de la famille des pyrethroides N-(3,5 dichlorophenyl) et des fongicides dicarboximide sur le metabolisme microsomal des enzymes chez la Caille japonaise (Coturnix coturnix)

International audienc

Perforator detection with a hand-held Doppler device: Importance of the learning curve

International audienc

Etude de la toxicite de l'Ioxynil et de sa localisation tissulaire chez le Lapin

National audienc

Delayed procedure in propeller perforator flap: Defining the venous perforasome

International audienc

Les cellules stromales mésenchymateuses du tissu adipeux : historique, isolement, propriétés immunomodulatrices et perspectives cliniques

National audienc