Superconductivity in NdFe1-xCoxAsO (0.05 < x < 0.20) and rare-earth magnetic ordering in NdCoAsO

The phase diagram of NdFe1-xCoxAsO for low cobalt substitution consists of a superconducting dome (0.05 < x < 0.20) with a maximum critical temperature of 16.5(2) K for x = 0.12. The x = 1 end member, NdCoAsO, is an itinerant ferromagnet (TC = 85 K) with an ordered moment of 0.30(1) BM at 15 K. Below TN = 9 K, Nd spin-ordering results in the antiferromagnetic coupling of the existing ferromagnetic planes. Rietveld analysis reveals that the electronically important two-fold tetrahedral angle increases from 111.4 to 115.9 deg. in this series. Underdoped samples with x = 0.046(2) and x = 0.065(2) show distortions to the orthorhombic Cmma structure at 72(2) and 64(2) K, respectively. The temperature dependences of the critical fields Hc2(T) near Tc are linear with almost identical slopes of 2.3(1) T K-1 for x = 0.065(2), x = 0.118(2) and x = 0.172(2). The estimated critical field Hc2(0) and correlation length for optimally doped samples are 26(1) T and 36(1) Angstrom. A comparison of the maximum reported critical temperatures of well-characterized cobalt doped 122- and 1111-type superconductors is presented.Comment: accepted to PR

Responding to Generative AI Technologies with Research-through-Design: The Ryelands AI Lab as an Exploratory Study

Generative AI technologies demand new practical and critical competencies, which call on design to respond to and foster these. We present an exploratory study guided by Research-through-Design, in which we partnered with a primary school to develop a constructionist curriculum centered on students interacting with a generative AI technology. We provide a detailed account of the design of and outputs from the curriculum and learning materials, finding centrally that the reflexive and prolonged `hands-on' approach led to a co-development of students' practical and critical competencies. From the study, we contribute guidance for designing constructionist approaches to generative AI technology education; further arguing to do so with `critical responsivity.' We then discuss how HCI researchers may leverage constructionist strategies in designing interactions with generative AI technologies; and suggest that Research-through-Design can play an important role as a `rapid response methodology' capable of reacting to fast-evolving, disruptive technologies such as generative AI.Comment: Conditionally Accepted at ACM DIS 202

Drivers of exceptionally cold North Atlantic Ocean temperatures and their link to the 2015 European heat wave

The North Atlantic and Europe experienced two extreme climate events in 2015: exceptionally cold ocean surface temperatures and a summer heat wave ranked in the top ten over the past 65 years. Here, we show that the cold ocean temperatures were the most extreme in the modern record over much of the mid-high latitude North-East Atlantic. Further, by considering surface heat loss, ocean heat content and wind driven upwelling we explain for the first time the genesis of this cold ocean anomaly. We find that it is primarily due to extreme ocean heat loss driven by atmospheric circulation changes in the preceding two winters combined with the re-emergence of cold ocean water masses. Furthermore, we reveal that a similar cold Atlantic anomaly was also present prior to the most extreme European heat waves since the 1980s indicating that it is a common factor in the development of these events. For the specific case of 2015, we show that the ocean anomaly is linked to a stationary position of the Jet Stream that favours the development of high surface temperatures over Central Europe during the heat wave. Our study calls for an urgent assessment of the impact of ocean drivers on major European summer temperature extremes in order to provide better advance warning measures of these high societal impact events

Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice

Previous work has shown that motor skill learning stimulates and requires generation of myelinating oligodendrocytes (OLs) from their precursor cells (OLPs) in the brains of adult mice. In the present study we ask whether OL production is also required for non-motor learning and cognition, using T-maze and radial-arm-maze tasks that tax spatial working memory. We find that maze training stimulates OLP proliferation and OL production in the medial prefrontal cortex (mPFC), anterior corpus callosum (genu), dorsal thalamus and hippocampal formation of adult male mice; myelin sheath formation is also stimulated in the genu. Genetic blockade of OL differentiation and neo-myelination in Myrf conditional-knockout mice strongly impairs training-induced improvements in maze performance. We find a strong positive correlation between the performance of individual wild type mice and the scale of OLP proliferation and OL generation during training, but not with the number or intensity of c-Fos+ neurons in their mPFC, underscoring the important role played by OL lineage cells in cognitive processing

Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice

Previous work has shown that motor skill learning stimulates and requires generation of myelinating oligodendrocytes (OLs) from their precursor cells (OLPs) in the brains of adult mice. In the present study we ask whether OL production is also required for non-motor learning and cognition, using T-maze and radial-arm-maze tasks that tax spatial working memory. We find that maze training stimulates OLP proliferation and OL production in the medial prefrontal cortex (mPFC), anterior corpus callosum (genu), dorsal thalamus and hippocampal formation of adult male mice; myelin sheath formation is also stimulated in the genu. Genetic blockade of OL differentiation and neo-myelination in Myrf conditional-knockout mice strongly impairs training-induced improvements in maze performance. We find a strong positive correlation between the performance of individual wild type mice and the scale of OLP proliferation and OL generation during training, but not with the number or intensity of c-Fos+ neurons in their mPFC, underscoring the important role played by OL lineage cells in cognitive processing

Determination of cancer risk associated with germ line BRCA1 missense variants by functional analysis

©2007 American Association for Cancer Research. Published version of the paper reproduced here in accordance with the copyright policy of the publisher. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the publisher.Germ line inactivating mutations in BRCA1 confer susceptibility for breast and ovarian cancer. However, the relevance of the many missense changes in the gene for which the effect on protein function is unknown remains unclear. Determination of which variants are causally associated with cancer is important for assessment of individual risk. We used a functional assay that measures the transactivation activity of BRCA1 in combination with analysis of protein modeling based on the structure of BRCA1 BRCT domains. In addition, the information generated was interpreted in light of genetic data. We determined the predicted cancer association of 22 BRCA1 variants and verified that the common polymorphism S1613G has no effect on BRCA1 function, even when combined with other rare variants. We estimated the specificity and sensitivity of the assay, and by meta-analysis of 47 variants, we show that variants with 50% can be classified as neutral. In conclusion, we did functional and structure-based analyses on a large series of BRCA1 missense variants and defined a tentative threshold activity for the classification missense variants. By interpreting the validated functional data in light of additional clinical and structural evidence, we conclude that it is possible to classify all missense variants in the BRCA1 COOH-terminal region. These results bring functional assays for BRCA1 closer to clinical applicability. [Cancer Res 2007;67(4):1494–501

Impact of model resolution on Arctic sea ice and North Atlantic Ocean heat transport

Arctic sea-ice area and volume have substantially decreased since the beginning of the satellite era. Concurrently, the pole-ward heat transport from the North Atlantic Ocean into the Arctic has increased, partly contributing to the loss of sea ice. Increasing the horizontal resolution of general circulation models (GCMs) improves their ability to represent the complex interplay of processes at high latitudes. Here, we investigate the impact of model resolution on Arctic sea ice and Atlantic Ocean heat transport (OHT) by using five different state-of-the-art coupled GCMs (12 model configurations in total) that include dynamic representations of the ocean, atmosphere and sea ice. The models participate in the High Resolution Model Intercomparison Project (HighResMIP) of the sixth phase of the Coupled Model Intercomparison Project (CMIP6). Model results over the period 1950–2014 are compared to different observational datasets. In the models studied, a finer ocean resolution drives lower Arctic sea-ice area and volume and generally enhances Atlantic OHT. The representation of ocean surface characteristics, such as sea-surface temperature (SST) and velocity, is greatly improved by using a finer ocean reso-lution. This study highlights a clear anticorrelation at interannual time scales between Arctic sea ice (area and volume) and Atlantic OHT north of 60 ◦N in the models studied. However, the strength of this relationship is not systematically impacted by model resolution. The higher the latitude to compute OHT, the stronger the relationship between sea-ice area/volume and OHT. Sea ice in the Barents/Kara and Greenland–Iceland–Norwegian (GIN) Seas is more strongly connected to Atlantic OHT than other Arctic seas

Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005

Human enterovirus 71, but not coxsackievirus A16, is strongly associated with acute neurologic disease

Sentinel surveillance for human enterovirus 71 in Sarawak, Malaysia: lessons from the first 7 years

BACKGROUND: A major outbreak of human enterovirus 71-associated hand, foot and mouth disease in Sarawak in 1997 marked the beginning of a series of outbreaks in the Asia Pacific region. Some of these outbreaks had unusually high numbers of fatalities and this generated much fear and anxiety in the region. METHODS: We established a sentinel surveillance programme for hand, foot and mouth disease in Sarawak, Malaysia, in March 1998, and the observations of the first 7 years are described here. Virus isolation, serotyping and genotyping were performed on throat, rectal, vesicle and other swabs. RESULTS: During this period Sarawak had two outbreaks of human enterovirus 71, in 2000 and 2003. The predominant strains circulating in the outbreaks of 1997, 2000 and 2003 were all from genogroup B, but the strains isolated during each outbreak were genetically distinct from each other. Human enterovirus 71 outbreaks occurred in a cyclical pattern every three years and Coxsackievirus A16 co-circulated with human enterovirus 71. Although vesicles were most likely to yield an isolate, this sample was not generally available from most cases and obtaining throat swabs was thus found to be the most efficient way to obtain virological information. CONCLUSION: Knowledge of the epidemiology of human enterovirus 71 transmission will allow public health personnel to predict when outbreaks might occur and to plan interventions in an effective manner in order to reduce the burden of disease