COYOTES, SHEEP AND LITHIUM CHLORIDE

The use of LiCl-treated baits and carcasses has been advocated as a means of controlling coyote predation on sheep through a process known as aversive conditioning or taste aversion. While some investigators have made well publicized claims of damage reduction through the use of LiCl on sheep ranges, other researchers have experienced difficulty establishing prey aversion in captive coyotes. The conflicting results suggest a need for extensive, carefully controlled research in both pen and field situations before valid conclusions can be reached regarding aversive conditioning as a depredations control method

COYOTES, SHEEP AND LITHIUM CHLORIDE

The use of LiCl-treated baits and carcasses has been advocated as a means of controlling coyote predation on sheep through a process known as aversive conditioning or taste aversion. While some investigators have made well publicized claims of damage reduction through the use of LiCl on sheep ranges, other researchers have experienced difficulty establishing prey aversion in captive coyotes. The conflicting results suggest a need for extensive, carefully controlled research in both pen and field situations before valid conclusions can be reached regarding aversive conditioning as a depredations control method

Biola Hour Highlights, 1974 - 08

A Christian Says \u27Thank You\u27 by Gerald Griffiths The Four Suppers of the New Testament by Al Sanders The Revelation of Jesus Christ by Lloyd Anderson Panel Discussions with Richard Chase, Vern Lewis, and Norman Wrighthttps://digitalcommons.biola.edu/bhhs/1007/thumbnail.jp

The single cell transcriptional landscape of esophageal adenocarcinoma and its modulation by neoadjuvant chemotherapy

Immune checkpoint blockade has recently proven effective in subsets of patients with esophageal adenocarcinoma (EAC) but little is known regarding the EAC immune microenvironment. We determined the single cell transcriptional profile of EAC in 8 patients who were treatment-naive (n = 4) or had received neoadjuvant chemotherapy (n = 4). Analysis of 52,387 cells revealed 10 major cell subsets of tumor, immune and stromal cells. Prior to chemotherapy tumors were heavy infiltrated by T regulatory cells and exhausted effector T cells whilst plasmacytoid dendritic cells were markedly expanded. Two dominant cancer-associated fibroblast populations were also observed whilst endothelial populations were suppressed. Pathological remission following chemotherapy associated with broad reversal of immune abnormalities together with fibroblast transition and an increase in endothelial cells whilst a chemoresistant epithelial stem cell population correlated with poor response. These findings reveal features that underlie and limit the response to current immunotherapy and identify a range of novel opportunities for targeted therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12943-022-01666-x

Open models for removal data

Individuals of protected species, such as amphibians and reptiles, often need to be removed from sites before development commences. Usually, the population is considered to be closed. All individuals are assumed to i) be present and available for detection at the start of the study period and ii) remain at the site until the end of the study, unless they are detected. However, the assumption of population closure is not always valid. We present new removal models which allow for population renewal through birth and/or immigration, and population depletion through sampling as well as through death/emigration. When appropriate, productivity may be estimated and a Bayesian approach allows the estimation of the probability of total population depletion. We demonstrate the performance of the models using data on common lizards, Zootoca vivipara, and great crested newts, Triturus cristatus

ASCA Observations of the Starburst-Driven Superwind Galaxy NGC 2146: Broad Band (0.6 - 9 keV) Spectral Properties

We report ASCA GIS and SIS observations of the nearby (D = 11.6 Mpc), nearly edge-on, starburst galaxy NGC 2146. These X-ray spectral data complement ROSAT PSPC and HRI imaging discussed by Armus et al., 1995. The broad band (0.6-9 keV) X-ray spectrum of NGC 2146 is best described by a two component model: the soft X-ray emission with a Raymond-Smith thermal plasma model having a temperature of kT $\sim 0.8$ keV; the hard X-ray emission with a thermal plasma model having kT $\sim 8$ keV or a power-law model having a photon index of $\sim 1.7$. We do not find compelling evidence of substantial excess absorption above the Galactic value. The soft (hard) thermal component provides about 30% (70%) of the total luminosity in the 0.5 - 2.0 keV energy band, while in the 2-10 keV energy range only the hard component plays a major role. The spectral results allow us to set tighter constraints on the starburst-driven superwind model, which we show can satisfactorily account for the luminosity, mass, and energy content represented by the soft X-ray spectral component. We estimate that the mass outflow rate ($\sim$ 9 M$_{\odot}$ per year) is about an order of magnitude greater than the predicted rate at which supernovae and stellar winds return mass into the interstellar medium and, therefore, argue that the flow is strongly "mass-loaded" with material in and around the starburst. The estimated outflow velocity of the hot gas is close to the escape velocity from the galaxy, so the fate of the gas is not clear. We suggest that the hard X-ray spectral component is due to the combined emission of X-ray binaries and/or young supernovae remnants associated with the starburst.Comment: 26 pages plus 4 figures, LaTex manuscript, Accepted for publication in the Astrophysical Journa

Definitive chemoradiotherapy versus neoadjuvant chemoradiotherapy followed by radical surgery for locally advanced oesophageal squamous cell carcinoma:meta-analysis

Background: The literature lacks robust evidence comparing definitive chemoradiotherapy (dCRT) with neoadjuvant chemoradiotherapy and surgery (nCRS) for oesophageal squamous cell carcinoma (ESCC). This study aimed to compare long-term survival of these approaches in patients with ESCC.Methods: A systematic review performed according to PRISMA guidelines included studies identified from PubMed, Scopus, and Cochrane CENTRAL databases up to July 2021 comparing outcomes between dCRT and nCRS for ESCC. The main outcome measure was overall survival (OS), secondary outcome was disease-free survival (DFS). A meta-analysis was conducted using random-effects modelling to determine pooled adjusted multivariable hazard ratios (HRs).Results: Ten studies including 14 092 patients were included, of which 30 per cent received nCRS. Three studies were randomized clinical trials (RCTs) and the remainder were retrospective cohort studies. dCRT and nCRS regimens were reported in six studies and surgical quality control was reported in two studies. Outcomes for OS and DFS were reported in eight and three studies respectively. Following meta-analysis, nCRS demonstrated significantly longer OS (HR 0.68, 95 per cent c.i. 0.54 to 0.87, P < 0.001) and DFS (HR 0.50, 95 per cent c.i. 0.36 to 0.70, P < 0.001) compared with dCRT.Conclusion: Neoadjuvant chemoradiotherapy followed by oesophagectomy correlated with improved survival compared with definitive chemoradiation in the treatment of ESCC; however, there is a lack of literature on RCTs

Biola Hour Highlights, 1974 - 09

How to Win Over Worry by Gerald Griffiths Psalm 37: The Psalm of Serenity by Al Sanders The Revelation of Jesus Christ by Lloyd Anderson Panel Discussions with Richard Chase, Charles Feinberg, and Samuel Sutherlandhttps://digitalcommons.biola.edu/bhhs/1008/thumbnail.jp