Immunotherapy and combined treatment approaches to angiogenesis inhibition

Verheul, H.M.W. [Promotor]Griffioen, A.W. [Promotor]Vliet, J.J. van der [Copromotor

London Street: A Memoir (Book Review)

Reviewed Title: London Street: A Memoir by Jane E. Griffioen . Eugene, Oregon: Resource Publications, 2020. 248 pp. ISBN: 9781725267558

De Frontlinie : bestaansonzekerheid en gentrificatie in de Creatieve Stad

Het dossier De Frontlinie: Bestaansonzekerheid en gentrificatie in de Creatieve Stad, samengesteld door Roel Griffioen, onderzoekt de relatie tussen nieuwe ontwikkelingen in het cultuurbeleid en de gentrificatiepolitiek die de Nederlandse steden steeds duurder en ontoegankelijker maakt. Wat is de functie van goedkoop gefabriceerde creativiteit in een politiek-economisch systeem dat bestaansonzekerheid creëert en oogst, een stedelijk beleid dat gentrificatie stimuleert, een cultuurbeleid dat ‘nuttige’ kunst aanmoedigt, en een woonbeleid dat wonen onzekerder maakt? Inhoud: Roel Griffioen, 'De precaire/creatieve stad'; Roel Griffioen en Abel Heijkamp, 'Woonnomadisme'; Roel Griffioen, 'Het vreemdelingenlegioen'; Roel Griffioen, 'Straatvrees'; Rufus de Vries, 'Stoelendans' [Beeldbijdrage]; Roel Griffioen, 'Netwerkhysterie: Interview met Pascal Gielen'; Isabell Lorey, 'Het regeren van precairen: een inleiding'; Łukasz Koterba, 'Brief uit Polen: Over de flexibele economie en de nationalistische jeugd'; Herbert Ploegman, 'Brief uit Griekenland: Een aanval op werkloosheid en precariteit in het centrum van Athene'; Adelita Husni-Bey, 'Groundwork: Thinking through the Convention on the Use of Space (just over) one year later'; Frank Keizer, 'Het was een tijd'

Norm and Context in the Social Sciences (Book Review)

Reviewed Title: Norm and Context in the Social Sciences. Sander Griffioen and Jan Verhoogt, eds. (New York: University Press of America) 1990. 295 pp

Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase

Minor histocompatibility antigens are the main targets of donor-derived T-cells after allogeneic stem cell transplantation. Identification of these antigens and understanding their biology are a key requisite for more insight into how graft vs. leukemia effect and graft vs. host disease could be separated. We here identified four new HLA class II-restricted minor histocompatibility antigens using whole genome association scanning. For one of the new antigens, i.e., LB-PIP4K2A-1S, we measured strong T-cell recognition of the donor variant PIP4K2A-1N when pulsed as exogenous peptide, while the endogenously expressed variant in donor EBV-B cells was not recognized. We showed that lack of T-cell recognition was caused by intracellular cleavage by a protease named asparagine endopeptidase (AEP). Furthermore, microarray gene expression analysis showed that PIP4K2A and AEP are both ubiquitously expressed in a wide variety of healthy tissues, but that expression levels of AEP were lower in primary acute myeloid leukemia (AML). In line with that, we confirmed low activity of AEP in AML cells and demonstrated that HLA-DRB1*03:01 positive primary AML expressing LB-PIP4K2A-1S or its donor variant PIP4K2A-1N were both recognized by specific T-cells. In conclusion, LB-PIP4K2A-1S not only represents a novel minor histocompatibility antigen but also provides evidence that donor T-cells after allogeneic stem cell transplantation can target the autologous allelic variant as leukemia-associated antigen. Furthermore, it demonstrates that endopeptidases can play a role in cell type-specific intracellular processing and presentation of HLA class II-restricted antigens, which may be explored in future immunotherapy of AML

Are You There, God? It’s Me, the Theist: On the Viability and Virtue of Non-Doxastic Prayer

In this article, I explore the possibility of what I call “non-doxastic theistic prayer”, namely prayer that proceeds without full belief in God – or in the kind of God who could be the recipient of such prayer. After developing a working definition of prayer, I proceed to discuss a few prominent forms of prayer and explore the ways in which such prayer might legitimately be performed non-doxastically. I conclude by examining the possibility that some forms of what I call “prayerful pretense” may be more epistemically and morally virtuous than their fully doxastic counterparts

Religious Experience without Belief? Toward an Imaginative Account of Religious Engagement

It is commonly supposed that a certain kind of belief is necessary for religious experience. Yet it is not clear that this must be so. In this article, I defend the possibility that a subject could have a genuine emotional religious experience without thereby necessarily believing that the purported object of her experience corresponds to reality and/or is the cause of her experience. Imaginative engagement, I argue, may evoke emotional religious experiences that may be said to be both genuine and appropriate, despite not necessarily including beliefs of the aforementioned kind.I go on to maintain that such religious engagement is compatible not only with non-belief but also with disbelief

Geochemical reactivity of subsurface sediments as potential buffer to anthropogenic inputs: a strategy for regional characterization in the Netherlands

Geochemical reactivity of subsurface sediments as potential buffer to anthropogenic inputs: a strategy for regional characterization in the Netherland

MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not.

The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(-1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9(-1562C>T) was not. Tumour MMP levels were not determined by their SNP genotypes