Guidance, flight mechanics and trajectory optimization. Volume 11 - Guidance equations for orbital operations

Mathematical formulation of guidance equations and solutions for orbital space mission

Guidance, Flight Mechanics and Trajectory Optimization. Volume 5 - State Determination And/or Estimation

Guidance, flight mechanics, and trajectory optimizatio

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking

Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment. In the present study, we undertook two approaches to determine the significance of plasticity involving system xc−. First, we examined whether the cysteine prodrug N-acetylcysteine attenuates cocaine-primed reinstatement by targeting system xc−. Rats were trained to self-administer cocaine (1 mg/kg/200 μl, i.v.) under extended access conditions (6 h/day). After extinction training, cocaine (10 mg/kg, i.p.) primed reinstatement was assessed in rats pretreated with N-acetylcysteine (0–60 mg/kg, i.p.) in the presence or absence of the system xc− inhibitor (S)-4-carboxyphenylglycine (CPG; 0.5 μM; infused into the nucleus accumbens). N-acetylcysteine attenuated cocaine-primed reinstatement, and this effect was reversed by co-administration of CPG. Secondly, we examined whether reduced system xc− activity is necessary for cocaine-primed reinstatement. To do this, we administered N-acetylcysteine (0 or 90 mg/kg, i.p.) prior to 12 daily self-administration sessions (1 mg/kg/200 μl, i.v.; 6 h/day) since this procedure has previously been shown to prevent reduced activity of system xc−. On the reinstatement test day, we then acutely impaired system xc− in some of the rats by infusing CPG (0.5 μM) into the nucleus accumbens. Rats that had received N-acetylcysteine prior to daily self-administration sessions exhibited diminished cocaine-primed reinstatement; this effect was reversed by infusing the cystine–glutamate exchange inhibitor CPG into the nucleus accumbens. Collectively these data establish system xc− in the nucleus accumbens as a key mechanism contributing to cocaine-primed reinstatement

Weak Long-Ranged Casimir Attraction in Colloidal Crystals

We investigate the influence of geometric confinement on the free energy of an idealized model for charge-stabilized colloidal suspensions. The mean-field Poisson-Boltzmann formulation for this system predicts pure repulsion among macroionic colloidal spheres. Fluctuations in the simple ions' distribution provide a mechanism for the macroions to attract each other at large separations. Although this Casimir interaction is long-ranged, it is too weak to influence colloidal crystals' dynamics.Comment: 5 pages 2 figures ReVTe

The PS 80 MHz cavities

As part of the preparation of the PS as injector for LHC, two new 80 MHz cavities have been designed and built at CERN. Bunches spaced by 25 ns and less than 4 ns long are required at injection into t he SPS. The bunch spacing is obtained with a 40 MHz system installed in the PS in 1996, but the nominal small bunch length will only be obtained with the 80 MHz systems producing a total of 600 kV. Th ese systems also have the capability to accelerate leptons in the PS, providing a total of 400 kV with high duty cycle (25 %). The mechanical design is similar to that of the 40 MHz cavity with many c ommon parts, but cooling water circuits had to be added. The cavity is equipped with an efficient, pneumatically operated, coaxial short-circuit. The power coupling loop has the form of a wide strip t o minimize the ratio of self to mutual inductance. It has a DC insulation permitting multipactor suppression by a bias voltage. The final amplifier is mounted directly onto the cavity. A fast RF feedb ack with a loop gain of 44 dB reduces the Q to about 100. Higher-order-mode dampers designed and built at TRIUMF have been installed

Repeated \u3cem\u3eN\u3c/em\u3e-Acetylcysteine Administration Alters Plasticity-Dependent Effects of Cocaine

Cocaine produces a persistent reduction in cystine–glutamate exchange via system xc− in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction. System xc− influences glutamate neurotransmission by maintaining basal, extracellular glutamate in the nucleus accumbens, which, in turn, shapes synaptic activity by stimulating group II metabotropic glutamate autoreceptors. In the present study, we tested the hypothesis that a long-term reduction in system xc− activity is part of the plasticity produced by repeated cocaine that results in the establishment of compulsive drug seeking. To test this, the cysteine prodrug N-acetylcysteine was administered before daily cocaine to determine the impact of increased cystine–glutamate exchange on the development of plasticity-dependent cocaine seeking. Although N-acetylcysteine administered before cocaine did not alter the acute effects of cocaine on self-administration or locomotor activity, it prevented behaviors produced by repeated cocaine including escalation of drug intake, behavioral sensitization, and cocaine-primed reinstatement. Because sensitization or reinstatement was not evident even 2–3 weeks after the last injection of N-acetylcysteine, we examined whether N-acetylcysteine administered before daily cocaine also prevented the persistent reduction in system xc− activity produced by repeated cocaine. Interestingly, N-acetylcysteine pretreatment prevented cocaine-induced changes in [35S]cystine transport via system xc−, basal glutamate, and cocaine-evoked glutamate in the nucleus accumbens when assessed at least 3 weeks after the last N-acetylcysteine pretreatment. These findings indicate that N-acetylcysteine selectively alters plasticity-dependent behaviors and that normal system xc− activity prevents pathological changes in extracellular glutamate that may be necessary for compulsive drug seeking

The PS 40 MHz bunching cavity

A 40 MHz cavity has been designed and built at CERN as part of the preparation of the PS as injector for LHC. The cavity will provide the necessary bunch spacing of 25 ns prior to injection into SPS and subsequently LHC. The mechanical design of the copper coated steel cavity was dominated by space constraints in the PS tunnel and by vacuum requirements. The salient design features described are i) tight, multipactor-free, capacitive coupling from the power amplifier, ii) fast RF feedback, iii) inductively coupled tuners, iv) an efficient, pneumatically operated gap short-circuit. The operation cycle consists of an adiabatic capture up to 100 kV gap voltage, a non-adiabatic jump to 300 kV, and subsequent bunch rotation. The multipactor voltage level at the gap lies below the operating voltage range and is easily passed through. A fast RF feedback system with a total group delay of 220 ns copes with heavy beam loading (1011 protons/bunch) and prevents unwanted interaction with other beams in the PS. The cavity has recently been installed, the nominal gap voltage of 300 kV has been attained, and bunch lengths below 8 ns have been achieved in first tests at nominal intensity. Experimental results are reported

Optical shield: measuring viscosity of turbid fluids using optical tweezers

The viscosity of a fluid can be measured by tracking the motion of a suspended micron-sized particle trapped by optical tweezers. However, when the particle density is high, additional particles entering the trap compromise the tracking procedure and degrade the accuracy of the measurement. In this work we introduce an additional Laguerre–Gaussian, i.e. annular, beam surrounding the trap, acting as an optical shield to exclude contaminating particles

Anomalous interactions in confined charge-stabilized colloid

Charge-stabilized colloidal spheres dispersed in weak 1:1 electrolytes are supposed to repel each other. Consequently, experimental evidence for anomalous long-ranged like-charged attractions induced by geometric confinement inspired a burst of activity. This has largely subsided because of nagging doubts regarding the experiments' reliability and interpretation. We describe a new class of thermodynamically self-consistent colloidal interaction measurements that confirm the appearance of pairwise attractions among colloidal spheres confined by one or two bounding walls. In addition to supporting previous claims for this as-yet unexplained effect, these measurements also cast new light on its mechanism.Comment: 8 pages, 5 figures, RevTeX4. Conference proceedings for CODEF-04, Colloidal Dispersions in External Fields, March 29 - April 1, 200