Feel, Don\u27t Think Review of the Application of Neuroscience Methods for Conversational Agent Research

Conversational agents (CAs) equipped with human-like features (e.g., name, avatar) have been reported to induce the perception of humanness and social presence in users, which can also increase other aspects of users’ affection, cognition, and behavior. However, current research is primarily based on self-reported measurements, leaving the door open for errors related to the self-serving bias, socially desired responding, negativity bias and others. In this context, applying neuroscience methods (e.g., EEG or MRI) could provide a means to supplement current research. However, it is unclear to what extent such methods have already been applied and what future directions for their application might be. Against this background, we conducted a comprehensive and transdisciplinary review. Based on our sample of 37 articles, we find an increased interest in the topic after 2017, with neural signal and trust/decision-making as upcoming areas of research and five separate research clusters, describing current research trends

Shared functional connectivity between the dorso-medial and dorso-ventral streams in macaques

© 2020, The Author(s). Manipulation of an object requires us to transport our hand towards the object (reach) and close our digits around that object (grasp). In current models, reach-related information is propagated in the dorso-medial stream from posterior parietal area V6A to medial intraparietal area, dorsal premotor cortex, and primary motor cortex. Grasp-related information is processed in the dorso-ventral stream from the anterior intraparietal area to ventral premotor cortex and the hand area of primary motor cortex. However, recent studies have cast doubt on the validity of this separation in separate processing streams. We investigated in 10 male rhesus macaques the whole-brain functional connectivity of these areas using resting state fMRI at 7-T. Although we found a clear separation between dorso-medial and dorso-ventral network connectivity in support of the two-stream hypothesis, we also found evidence of shared connectivity between these networks. The dorso-ventral network was distinctly correlated with high-order somatosensory areas and feeding related areas, whereas the dorso-medial network with visual areas and trunk/hindlimb motor areas. Shared connectivity was found in the superior frontal and precentral gyrus, central sulcus, intraparietal sulcus, precuneus, and insular cortex. These results suggest that while sensorimotor processing streams are functionally separated, they can access information through shared areas

Follow Me If You Want to Live - Understanding the Influence of Human-Like Design on Users’ Perception and Intention to Comply with COVID-19 Education Chatbots

Following recommendations and complying with behavioral attitudes is one major key in overcoming global pandemics, such as COVID-19. As the World Health Organization (WHO) highlights, there is an increased need to follow hygiene standards to prevent infections and in reducing the risk of infections transmissions (World-Health-Organization, 2021). This urgent need offers new use cases of digital services, such as conversational agents that educate and inform individuals about relevant counter measurements. Specifically, due to the increased fatigue in the population in the context of COVID-19, (Franzen and Wöhner, 2021), CAs can play a vital role in supporting and attaining user’s behavior. We conducted an experiment (n=116) to analyze the effect of a human-like-design CA on the intention to comply. Our results show a significant impact of a human-like design on the perception of humanness, source credibility, and trust, which are all (directly or indirectly) drivers of the intention to comply

Is it COVID or a Cold? An Investigation of the Role of Social Presence, Trust, and Persuasiveness for Users\u27 Intention to Comply with COVID-19 Chatbots

The COVID-19 pandemic challenged the existing healthcare system by demanding potential patients to self-diagnose and self-test a potential virus contraction. In this process, some individuals need help and guidance. However, the previous modus-operandi to go to a physician is no longer viable because of the limited capacity and danger of spreading the virus. Hence, digital means had to be developed to help and inform individuals at home, such as conversational agents (CA). The human-like design and perceived social presence of such a CA are central to attaining users’ compliance. Against this background, we surveyed 174 users of a commercial COVID-19 chatbot to investigate the role of perceived social presence. Our results provide support that the perceived social presence of chatbots leads to higher levels of trust, which are a driver of compliance. In contrast, perceived persuasiveness seems to have no significant effect

Towards a Greater Diversity of Replication Studies

The replication of existing knowledge (e.g., previous study results) stands as an essential research practice across all science disciplines. Despite the importance of replication, the scarcity of replication studies is commonly criticized in business, management, and information system (IS) research. Therefore, efforts have already been made to facilitate replication research in the IS community, such as establishing conference tracks and journals focusing on publishing replication studies and providing guidelines on how and why to conduct replication research. Nonetheless, the perception of replication research remains unchanged, describing it as mundane. Therefore, in this issues and opinions article, we will explore how replication research could be made more appealing by diversifying the categories of replication studies. In this regard, we looked at replication in neuroscience, eliciting two new replication study categories: ‘transfer’ and ‘method.’ Additionally, through extensive discussion with other IS scholars, we added one more replication category, ‘comparison.’ We hope that this diversification will attract more researchers and also show the potential replication research holds

Quantum-limited measurements of optical signals from a geostationary satellite

The measurement of quantum signals that traveled through long distances is of fundamental and technological interest. We present quantum-limited coherent measurements of optical signals, sent from a satellite in geostationary Earth orbit to an optical ground station. We bound the excess noise that the quantum states could have acquired after having propagated 38600 km through Earth's gravitational potential as well as its turbulent atmosphere. Our results indicate that quantum communication is feasible in principle in such a scenario, highlighting the possibility of a global quantum key distribution network for secure communication.Comment: 8 pages (4 pages main article, 4 pages supplementary material), 9 figures (4 figures main article, 5 figures supplementary material), Kevin G\"unthner and Imran Khan contributed equally to this wor

Medulloblastoma Exome Sequencing Uncovers Subtype-Specific Somatic Mutations

Medulloblastomas are the most common malignant brain tumors in children1. Identifying and understanding the genetic events that drive these tumors is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. Recently, our group and others described distinct molecular subtypes of medulloblastoma based on transcriptional and copy number profiles2–5. Here, we utilized whole exome hybrid capture and deep sequencing to identify somatic mutations across the coding regions of 92 primary medulloblastoma/normal pairs. Overall, medulloblastomas exhibit low mutation rates consistent with other pediatric tumors, with a median of 0.35 non-silent mutations per megabase. We identified twelve genes mutated at statistically significant frequencies, including previously known mutated genes in medulloblastoma such as CTNNB1, PTCH1, MLL2, SMARCA4 and TP53. Recurrent somatic mutations were identified in an RNA helicase gene, DDX3X, often concurrent with CTNNB1 mutations, and in the nuclear co-repressor (N-CoR) complex genes GPS2, BCOR, and LDB1, novel findings in medulloblastoma. We show that mutant DDX3X potentiates transactivation of a TCF promoter and enhances cell viability in combination with mutant but not wild type beta-catenin. Together, our study reveals the alteration of Wnt, Hedgehog, histone methyltransferase and now N-CoR pathways across medulloblastomas and within specific subtypes of this disease, and nominates the RNA helicase DDX3X as a component of pathogenic beta-catenin signaling in medulloblastoma

Quantification of silver nanoparticle uptake and distribution within individual human macrophages by FIB/SEM slice and view

Background Quantification of nanoparticle (NP) uptake in cells or tissues is very important for safety assessment. Often, electron microscopy based approaches are used for this purpose, which allow imaging at very high resolution. However, precise quantification of NP numbers in cells and tissues remains challenging. The aim of this study was to present a novel approach, that combines precise quantification of NPs in individual cells together with high resolution imaging of their intracellular distribution based on focused ion beam/ scanning electron microscopy (FIB/SEM) slice and view approaches. Results We quantified cellular uptake of 75 nm diameter citrate stabilized silver NPs (Ag 75 Cit) into an individual human macrophage derived from monocytic THP-1 cells using a FIB/SEM slice and view approach. Cells were treated with 10 μg/ml for 24 h. We investigated a single cell and found in total 3138 ± 722 silver NPs inside this cell. Most of the silver NPs were located in large agglomerates, only a few were found in clusters of fewer than five NPs. Furthermore, we cross-checked our results by using inductively coupled plasma mass spectrometry and could confirm the FIB/SEM results. Conclusions Our approach based on FIB/SEM slice and view is currently the only one that allows the quantification of the absolute dose of silver NPs in individual cells and at the same time to assess their intracellular distribution at high resolution. We therefore propose to use FIB/SEM slice and view to systematically analyse the cellular uptake of various NPs as a function of size, concentration and incubation time.TU Berlin, Open-Access-Mittel - 201