Emission Scenarios and the Health Risks Posed by Priority Mobile Air Toxics in an Urban to Regional Area: An Application in Nashville, Tennessee

Toxic air pollutants, also known as hazardous air pollutants, are those that are known or suspected to cause cancer or other serious health effects, such as birth defects or adverse environmental outcomes. The aim of this research was to predict air toxics related health risks due to different emission scenarios by linking Models-3/CMAQ and cancer risk assessments. To demonstrate the effectiveness of this approach, this study was performed on the priority mobile source air toxics (PMSAT) of benzene, 1,3-butadiene, formaldehyde, acetaldehyde, and diesel particulate matter (DPM), based on data from 2003. The analysis was carried out in the eastern US, and mainly in Nashville, TN. Ten emissions scenarios were examined, including a 2020 scenario with the effects of on-road mobile source regulations. The results show that DPM poses a cancer risk that is 4.2 times higher than the combined total cancer risk from all of four other PMSAT. These high cancer risk levels are mainly due to non-road sources (57.9%). The main cancer risk from acetaldehyde, benzene, formaldehyde, and 1,3-butadiene (4HAPs) is due to biogenic sources, which account for 32.2% of this risk, although these cannot be controlled. Excluding DPM, the main on-road cancer risk contribution was due to the air toxics generated by gasoline light duty vehicles (LDVs), principally benzene and 1,3-butadiene. The scenario for 2020 showed reductions in the adverse health effects related to DPM and 4HAPs of 32.8 and 19.4%, respectively. This research provides strong evidence that reducing ambient DPM concentrations will lead to greater improvements in human health than other air toxics, indicating that better technologies and regulations must be applied to mobile diesel engines, as these have more significant adverse health effects than non-road diesel sources

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia.

Acute myeloid leukemia (AML) cells meet the higher energy, metabolic, and signaling demands of the cell by increasing mitochondrial biogenesis and mitochondrial protein translation. Blocking mitochondrial protein synthesis through genetic and chemical approaches kills human AML cells at all stages of development in vitro and in vivo. Tigecycline is an antimicrobial that we found inhibits mitochondrial protein synthesis in AML cells. Therefore, we conducted a phase 1 dose-escalation study of tigecycline administered intravenously daily 5 of 7 days for 2 weeks to patients with AML. A total of 27 adult patients with relapsed and refractory AML were enrolled in this study with 42 cycles being administered over seven dose levels (50-350 mg/day). Two patients experienced DLTs related to tigecycline at the 350 mg/day level resulting in a maximal tolerated dose of tigecycline of 300 mg as a once daily infusion. Pharmacokinetic experiments showed that tigecycline had a markedly shorter half-life in these patients than reported for noncancer patients. No significant pharmacodynamic changes or clinical responses were observed. Thus, we have defined the safety of once daily tigecycline in patients with refractory AML. Future studies should focus on schedules of the drug that permit more sustained target inhibition

Open String Star as a Continuous Moyal Product

We establish that the open string star product in the zero momentum sector can be described as a continuous tensor product of mutually commuting two dimensional Moyal star products. Let the continuous variable $\kappa \in [~0,\infty)$ parametrize the eigenvalues of the Neumann matrices; then the noncommutativity parameter is given by $\theta(\kappa) =2\tanh(\pi\kappa/4)$. For each $\kappa$, the Moyal coordinates are a linear combination of even position modes, and the Fourier transform of a linear combination of odd position modes. The commuting coordinate at $\kappa=0$ is identified as the momentum carried by half the string. We discuss the relation to Bars' work, and attempt to write the string field action as a noncommutative field theory.Comment: 30 pages, LaTeX. One reference adde

An analysis of light pollution at the Thirty Meter Telescope candidate sites

Light pollution can create difficulties for astronomers attempting to observe faint objects in the night sky. Light from a local small town can be just as intrusive as light from a large city in the distance. As the population of the Earth increases, light pollution will become more of a problem, even in remote areas. The Thirty Meter Telescope site testing program has measured light pollution at the candidate sites by using all sky cameras; an analysis procedure enhances the all sky camera images to make the determination of the effects of the light pollution. This paper summarizes the light pollution analysis procedure and current results, which are that light pollution is currently unimportant for TMT to select a site for the final telescope location

Introduction of the Tools for Economic Analysis of Patient Management Interventions in Heart Failure Costing Tool: A User-Friendly Spreadsheet Program to Estimate Costs of Providing Patient-Centered Interventions

Background—Patient-centered health care interventions, such as heart failure disease management programs, are under increasing pressure to demonstrate good value. Variability in costing methods and assumptions in economic evaluations of such interventions limit the comparability of cost estimates across studies. Valid cost estimation is critical to conducting economic evaluations and for program budgeting and reimbursement negotiations. Methods and Results—Using sound economic principles, we developed the Tools for Economic Analysis of Patient Management Interventions in Heart Failure (TEAM-HF) Costing Tool, a spreadsheet program that can be used by researchers and health care managers to systematically generate cost estimates for economic evaluations and to inform budgetary decisions. The tool guides users on data collection and cost assignment for associated personnel, facilities, equipment, supplies, patient incentives, miscellaneous items, and start-up activities. The tool generates estimates of total program costs, cost per patient, and cost per week and presents results using both standardized and customized unit costs for side-by-side comparisons. Results from pilot testing indicated that the tool was well-formatted, easy to use, and followed a logical order. Cost estimates of a 12-week exercise training program in patients with heart failure were generated with the costing tool and were found to be consistent with estimates published in a recent study. Conclusions—The TEAM-HF Costing Tool could prove to be a valuable resource for researchers and health care managers to generate comprehensive cost estimates of patient-centered interventions in heart failure or other conditions for conducting high-quality economic evaluations and making well-informed health care management decisions

Fast-timing measurements in the ground-state band of 114Pd

Using a hybrid Gammasphere array coupled to 25 LaBr3(Ce) detectors, the lifetimes of the first three levels of the yrast band in 114Pd, populated via 252Cf decay, have been measured. The measured lifetimes are τ2+ = 103(10) ps, τ4+ = 22(13) ps, and τ6+ 10 ps for the 2+ 1 , 4+ 1 , and 6+ 1 levels, respectively. Palladium-114 was predicted to be the most deformed isotope of its isotopic chain, and spectroscopic studies have suggested it might also be a candidate nucleus for low-spin stable triaxiality. From the lifetimes measured in this work, reduced transition probabilities B(E2; J → J − 2) are calculated and compared with interacting boson model, projected shell model, and collective model calculations from the literature. The experimental ratio RB(E2) = B(E2; 4+ 1 → 2+ 1 )/B(E2; 2+ 1 → 0+ 1 ) = 0.80(42) is measured for the first time in 114Pd and compared with the known values RB(E2) in the palladium isotopic chain: the systematics suggest that, for N = 68, a transition from γ -unstable to a more rigid γ -deformed nuclear shape occurs.This work was financially supported by the Science and Technology Facility Council (STFC) Grants No. ST/L005840/1, No. ST/L005743/1, and No. ST/G000751/1. This work has also been partially supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics under Contract No. DE-AC02-06CH11357 (ANL). E.R.G. would like to acknowledge the STFC for funding via his Ph.D. studentship. D.J.H. acknowledges the National Science Foundation, Grant No. PHY-1502092. E.A.S. and O.Y. would like to acknowledge the project DFNI-E02/6

Oregon 2100: projected climatic and ecological changes

Greenhouse climatic warming is underway and exacerbated by human activities. Future outcomes of these processes can be projected using computer models checked against climatic changes during comparable past atmospheric compositions. This study gives concise quantitative predictions for future climate, landscapes, soils, vegetation, and marine and terrestrial animals of Oregon. Fossil fuel burning and other human activities by the year 2100 are projected to yield atmospheric CO2 levels of about 600-850 ppm (SRES A1B and B1), well above current levels of 400 ppm and preindustrial levels of 280 ppm. Such a greenhouse climate was last recorded in Oregon during the middle Miocene, some 16 million years ago. Oregon’s future may be guided by fossil records of the middle Miocene, as well as ongoing studies on the environmental tolerances of Oregon plants and animals, and experiments on the biological effects of global warming. As carbon dioxide levels increase, Oregon’s climate will move toward warm temperate, humid in the west and semiarid to subhumid to the east, with increased summer and winter drought in the west. Western Oregon lowlands will become less suitable for temperate fruits and nuts and Pinot Noir grapes, but its hills will remain a productive softwood forest resource. Improved pasture and winter wheat crops will become more widespread in eastern Oregon. Tsunamis and stronger storms will exacerbate marine erosion along the Oregon Coast, with significant damage to coastal properties and cultural resources

The secondary market for bank shares in nineteenth-century Britain

Stock transferability and liquidity are viewed as vital characteristics of capital markets. Surprisingly, we know very little about the level of trading activity on, and liquidity of the market for, company stock during the rapid growth of the British capital market in the nineteenth century. This article attempts to shed some light on this important issue by examining the market for bank shares using trading data collected from bank archives. Our evidence suggests that trading activity and liquidity changed imperceptibly over the century. We also find that ownership structure is a major determinant of trading activity and liquidity; whereas shareholder liability regimes don't appear to affect liquidity

Sustained replication of synthetic canine distemper virus defective genomes in vitro and in vivo

Defective interfering (DI) genomes have long been considered inconvenient artifacts that suppressed viral replication in vitr

New Particle-Induced Single Event Latchup Mechanism Observed in a Cryogenic CMOS Readout Integrated Circuit

No abstract availabl