Survival of the Richest: The Malthusian Mechanism in Pre-Industrial England

Fundamental to the Malthusian model of pre-industrial society is the assumption that higher income increased reproductive success. Despite the seemingly inescapable logic of this model, the empirical support for this vital assumption in the preindustrial world is weak. Here we examine the relationship between income and net fertility using a large new cross-sectional data set on reproductive success, social status and income for England between 1585 and 1638. We find that for early seventeenth century England, a society seemingly close to a Malthusian equilibrium, wealth at death robustly predicts reproductive success. The richest male testators left behind double the number of children of the poorest. Consequently in the static English economy of this period social mobility was generally downwards. The strong association in England between wealth and reproductive success seems to also extend back to at least 1250.england and economy

Fortnight

Fortnight is a two-week long, fully immersive, experience based in the interactions and communications of daily life. Up to 200 participants sign up to receive messages that are sent to their mobile phones, email, and home address; these messages contain a series of poetic nudges that encourage those participating to question their sense of place. Participants also receive daily invitations to visit locations throughout their city where they can pause to reflect on what it means to be here now. Fortnight enables the experience of “theatre” to penetrate beneath a seemingly brittle aesthetic surface of performance, deep into the consciousnesses of our participants as they begin to interact with and perceive world around us as the performance itself; the place where we act out our own daily lives. In Fortnight, the spectator becomes participant; the journey becomes narrative. Fortnight therefore subverts the notion of an audience, in which each spectator’s perspective is forced to examine not the situation and setting of performers on a stage, but rather the situation and setting of our own sense of place and the meaning we apportion to our everyday lives. Fortnight uses various forms of ubiquitous technology such as: Radio Frequency Identification (aka, RFID tags of the type contained in key fobs), which are used in badges sent to each participant that allow them to interact with real-world “portals” to trigger certain effects in their surroundings; QR technology (in the form of barcodes on posters that reveal additional hidden messages, should the participant choose to delve further; SMS messages; email; and, Twitter. Alongside this, older modes of communication such as handwritten letters, give Fortnight a decidedly low-fi aesthetic. Throughout Fortnight, participants are encouraged to explore the creative possibilities of pervasive and communicative media without reverting to mere technological fetishism. In Fortnight, each mode of communication is used not only for its functionality but also as symbols that bind the project and the participant together, rooting them to the here and now with the everyday tools of modern society. The mediated messages within Fortnight lead participants down a living, breathing rabbit hole where the familiar becomes unfamiliar and reality distorts. The project becomes an experience for the participant that is as immersive as their own life; creating an alternative reality, that not only co-exists alongside their own everyday realities, but also merges with them.This is a performance with shared responsibilities, reflecting the actions and consequences of our daily lives: what we put in, we get out

The Use of Hospice Care in End-Stage Psychiatric Patients

Hospice care is rarely used in end-stage psychiatric patients, yet situations exist where psychiatric intervention is futile and comfort care is the best option. Delusional disorder is rare, typically begins later in life, and has a chronic course that responds poorly to treatment. The prognosis is affected by factors such as chronicity and insight. A case of a chronic and intractable delusional disorder that affected eating behavior and subsequently caused serious medical complications. Due to the severity of the case and the unique ethical issues it presented, the prognosis was determined to be poor and the patient was discharged home with hospice care. The case presented a rare opportunity to assess hospice care provided to an end-stage psychiatric patient.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90449/1/jpm-2E2009-2E0431.pd

Multilevel modeling of binary outcomes with three-level complex health survey data.

Complex survey designs often involve unequal selection probabilities of clus-ters or units within clusters. When estimating models for complex survey data, scaled weights are incorporated into the likelihood, producing a pseudo likeli-hood. In a 3-level weighted analysis for a binary outcome, we implemented two methods for scaling the sampling weights in the National Health Survey of Pa-kistan (NHSP). For NHSP with health care utilization as a binary outcome we found age, gender, household (HH) goods, urban/rural status, community de-velopment index, province and marital status as significant predictors of health care utilization (p-value \u3c 0.05). The variance of the random intercepts using scaling method 1 is estimated as 0.0961 (standard error 0.0339) for PSU level, and 0.2726 (standard error 0.0995) for household level respectively. Both esti-mates are significantly different from zero (p-value \u3c 0.05) and indicate consid-erable heterogeneity in health care utilization with respect to households and PSUs. The results of the NHSP data analysis showed that all three analyses, weighted (two scaling methods) and un-weighted, converged to almost identical results with few exceptions. This may have occurred because of the large num-ber of 3rd and 2nd level clusters and relatively small ICC. We performed a sim-ulation study to assess the effect of varying prevalence and intra-class correla-tion coefficients (ICCs) on bias of fixed effect parameters and variance components of a multilevel pseudo maximum likelihood (weighted) analysis. The simulation results showed that the performance of the scaled weighted estimators is satisfactory for both scaling methods. Incorporating simulation into the analysis of complex multilevel surveys allows the integrity of the results to be tested and is recommended as good practice

Cycad Aulacaspis Scale, a Newly Introduced Insect Pest in Indonesia

Cycad aulacaspis scale (Aulacaspis yasumatsui Takagi (Hemiptera: Diaspididae)) is native to Thailand and Vietnam. Since the early 1990s it has been spreading around the world due to the trade in cycad plants for ornamental use. Infestation by this scale can kill cycads in only a few months. Its accidental introduction to Florida endangered the ornamental cycad-growing industry; and in Guam and Taiwan, endemic cycads (Cycas micronesica and C. taitungensis, respectively) are currently threatened with extinction by cycad aulacaspis scale. In November 2011, an introduced scale was discovered damaging cycads in the Bogor Botanic Garden. Samples from Bogor were taken for identification of the scale, and the material was kept for some time to rear out any insect parasitoids that were present. Both the scale insects and parasitoids were prepared on microscope slides and studied microscopically for authoritative identification. The scale was confirmed as A. yasumatsui. The parasitoid Arrhenophagus chionaspidis Aurivillius (Hymenoptera: Encyrtidae) and the hyperparasitoid Signiphora bifasciata Ashmead (Hymenoptera: Signiphoridae) were identified from the samples. Unless immediate remedial measures are taken, several endemic species of cycad in Indonesia may be endangered by infestation by cycad aulacaspis scale

Spectroscopy of Quasar Candidates from SDSS Commissioning Data

The Sloan Digital Sky Survey has obtained images in five broad-band colors for several hundred square degrees. We present color-color diagrams for stellar objects, and demonstrate that quasars are easily distinguished from stars by their distinctive colors. Follow-up spectroscopy in less than ten nights of telescope time has yielded 22 new quasars, 9 of them at $z> 3.65$, and one with $z = 4.75$, the second highest-redshift quasar yet known. Roughly 80% of the high-redshift quasar candidates selected by color indeed turn out to be high-redshift quasars.Comment: 4 pages, 3 figures, to appear in the proceedings of "After the Dark Ages: When Galaxies were Young (the Universe at 2<z<5)", 9th Annual October Astrophysics Conference in Marylan

The Angular Clustering of Galaxy Pairs

We identify close pairs of galaxies from 278 deg^2 of Sloan Digital Sky Survey commissioning imaging data. The pairs are drawn from a sample of 330,041 galaxies with 18 < r^* < 20. We determine the angular correlation function of galaxy pairs, and find it to be stronger than the correlation function of single galaxies by a factor of 2.9 +/- 0.4. The two correlation functions have the same logarithmic slope of 0.77. We invert Limber's equation to estimate the three-dimensional correlation functions; we find clustering lengths of r_0= 4.2 +/- 0.4 h^{-1} Mpc for galaxies and 7.8 +/- 0.7 h^{-1} Mpc for galaxy pairs. These results agree well with the global richness dependence of the correlation functions of galaxy systems.Comment: 12 pages. ApJ, in pres

New Class of Precision Antimicrobials Redefines Role of Clostridium difficile S-layer in Virulence and Viability

There is a medical need for antibacterial agents that do not damage the resident gut microbiota or promote the spread of antibiotic resistance. We recently described a prototypic precision bactericidal agent, Av-CD291.2, which selectively kills specific Clostridium difficile strains and prevents them from colonizing mice. We have since selected two Av-CD291.2–resistant mutants that have a surface (S)-layer–null phenotype due to distinct point mutations in the slpA gene. Using newly identified bacteriophage receptor binding proteins for targeting, we constructed a panel of Avidocin-CDs that kills diverse C. difficile isolates in an S-layer sequence-dependent manner. In addition to bacteriophage receptor recognition, characterization of the mutants also uncovered important roles for S-layer protein A (SlpA) in sporulation, resistance to innate immunity effectors, and toxin production. Surprisingly, S-layer–null mutants were found to persist in the hamster gut despite a complete attenuation of virulence. These findings suggest antimicrobials targeting virulence factors dispensable for fitness in the host force pathogens to trade virulence for viability and would have clear clinical advantages should resistance emerge. Given their exquisite specificity for the pathogen, Avidocin-CDs have substantial therapeutic potential for the treatment and prevention of C. difficile infections

Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing

Women facing increased energetic demands in childhood commonly have altered adult ovarian activity and shorter reproductive lifespan, possibly comprising a strategy to optimize reproductive success. Here we sought to understand the mechanisms of early-life programming of reproductive function, by integrating analysis of reproductive tissues in an appropriate mouse model with methylation analysis of proxy tissue DNA in a well-characterized population of Bangladeshi migrants in the UK. Bangladeshi women whose childhood was in Bangladesh were found to have later pubertal onset and lower age-matched ovarian reserve than Bangladeshi women who grew-up in England. Subsequently we aimed to explore the potential relevance to the altered reproductive phenotype of one of the genes that emerged from the screens. Results: Of the genes associated with differential methylation in the Bangladeshi women whose childhood was in Bangladesh as compared to Bangladeshi women who grew up in the UK, 13 correlated with altered expression of the orthologous gene in the mouse model ovaries. These mice had delayed pubertal onset and a smaller ovarian reserve compared to controls. The most relevant of these genes for reproductive function appeared to be SRD5A1, which encodes the steroidogenic enzyme 5α reductase-1. SRD5A1 was more methylated at the same transcriptional enhancer in mice ovaries as in the women’s buccal DNA, and its expression was lower in the hypothalamus of the mice as well, suggesting a possible role in the central control of reproduction. The expression of Kiss1 and Gnrh was also lower in these mice compared to controls, and inhibition of 5α reductase-1 reduced Kiss1 and Gnrh mRNA levels and blocked GnRH release in GnRH neuronal cell cultures. Crucially, we show that inhibition of this enzyme in female mice in vivo delayed pubertal onset. Conclusions: SRD5A1/5α reductase-1 responds epigenetically to the environment and its down-regulation appears to alter the reproductive phenotype. These findings help to explain diversity in reproductive characteristics and how they are shaped by early-life environment, and reveal novel pathways that might be targeted to mitigate health issues caused by life-history trade-offs