Comparison of regional gene expression differences in the brains of the domestic dog and human

Comparison of the expression profiles of 2,721 genes in the cerebellum, cortex and pituitary gland of three American Staffordshire terriers, one beagle and one fox hound revealed regional expression differences in the brain but failed to reveal marked differences among breeds, or even individual dogs. Approximately 85 per cent (42 of 49 orthologue comparisons) of the regional differences in the dog are similar to those that differentiate the analogous human brain regions. A smaller percentage of human differences were replicated in the dog, particularly in the cortex, which may generally be evolving more rapidly than other brain regions in mammals. This study lays the foundation for detailed analysis of the population structure of transcriptional variation as it relates to cognitive and neurological phenotypes in the domestic dog

Understanding the role of performance targets in transport policy

The measurement of performance in the public sector has become increasingly important in recent years and it is now commonplace for transport organisations, and local and national governments, to publish performance goals for service supply and quality. Such commitments, when time referenced, are known as targets. This paper explain how changes in management style, consumer rights legislation, contractual obligations and other factors have combined to make management-by targets increasingly common in the public sector. The advantages and disadvantages of management-by-targets are illustrated through discussion of the processes and experience of setting transport targets in UK national transport policy. We conclude that while some of the targets have had a significant impact on policy makers, managers and their agents, the effects have not always been as intended

Radial Velocity Studies of Close Binary Stars.VIII

Radial-velocity measurements and sine-curve fits to the orbital velocity variations are presented for the seventh set of ten close binary systems: V410 Aur, V523 Cas, QW Gem, V921 Her, V2357 Oph, V1130 Tau, HN UMa, HX UMa, HD 93917, NSV 223. All systems, but three (V523 Cas, HD 93917, NSV 223), were discovered photometrically by the Hipparcos mission. All systems are double-lined (SB2) binaries and all, but the detached, very close system V1130 Tau, are contact binaries. The broadening-function permitted improvement of the orbital elements for V523 Cas, which was the only system observed before for radial velocity variations. Spectroscopic/visual companions were detected for V410 Aur and HX UMa.Comment: AASTeX5, 4 figures, 3 tables, to appear AJ, June 200

Ariel - Volume 9 Number 3

Executive Editor Emily Wofford Business Manager Fredric Jay Matlin University News John Patrick Welch World News George Robert Coar Editorials Editor Steve Levine Features Mark Rubin Brad Feldstein Photo Rick Spaide Circulation Victor Onufreiczuk Lee Wugofski Graphics and Art Steve Hulkower Commons Editor Brenda Peterso

Evaluating differences in the clinical impact of a free online weight loss programme, a resource-intensive commercial weight loss programme and an active control condition: a parallel randomised controlled trial

Background Finding effective intervention strategies to combat rising obesity levels could significantly reduce the burden that obesity and associated non-communicable diseases places on both individuals and the National Health Service. Methods In this parallel randomised-controlled trial, 76 participants who are overweight or obese (50 female) were given free access to a fitness centre for the duration of the 12-week intervention and randomised to one of three interventions. The commercial intervention, the Healthy Weight Programme, (HWP, n=25, 10/15 men/women) consisted of twelve 1-hour nutrition coaching sessions with a nutritionist delivered as a mixture of group and 1 to 1 sessions. In addition, twice-weekly exercise sessions (24 in total) were delivered by personal trainers for 12 weeks. The NHS intervention (n=25, 8/17 men/women) consisted of following an entirely self-managed 12-week online NHS resource. The GYM intervention (n=26, 8/18 men/women) received no guidance or formal intervention. All participants were provided with a gym induction for safety and both the NHS and GYM participants were familiarised with ACSM physical activity guidelines by way of a hand-out. Results The overall follow-up rate was 83%. Body mass was significantly reduced at post-intervention in all groups (HWP: N=18, -5.17±4.22 kg, NHS: N=21 -4.19±5.49 kg; GYM: N=24 - 1.17±3.00 kg; p < 0.001) with greater reductions observed in HWP and NHS groups compared to GYM (p<0.05). Out with body mass and BMI, there were no additional statistically significant time x intervention interaction effects Conclusions This is the first study to evaluate the efficacy of both a free online NHS self-help weight-loss tool and a commercial weight loss programme that provides face-to-face nutritional support and supervised exercise. The findings suggest that both interventions are superior to an active control condition with regard to eliciting short-term weight-loss

Drug-responsive autism phenotypes in the 16p11.2 deletion mouse model: a central role for gene-environment interactions

There are no current treatments for autism, despite its high prevalence. Deletions of chromosome 16p11.2 dramatically increase risk for autism, suggesting that mice with an equivalent genetic rearrangement may offer a valuable model for the testing of novel classes of therapeutic drug. 16p11.2 deletion (16p11.2 DEL) mice and wild-type controls were assessed using an ethological approach, with 24 h monitoring of activity and social interaction of groups of mice in a home-cage environment. The ability of the excitation/inhibition modulator N-acetyl cysteine (NAC) and the 5-HT1B/1D/1F receptor agonist eletriptan to normalise the behavioural deficits observed was tested. 16p11.2 DEL mice exhibited largely normal behaviours, but, following the stress of an injection, showed hyperlocomotion, reduced sociability, and a strong anxiolytic phenotype. The hyperactivity and reduced sociability, but not the suppressed anxiety, were effectively attenuated by both NAC and eletriptan. The data suggest that 16p11.2 DEL mice show an autism-relevant phenotype that becomes overt after an acute stressor, emphasising the importance of gene-environmental interactions in phenotypic analysis. Further, they add to an emerging view that NAC, or 5-HT1B/1D/1F receptor agonist treatment, may be a promising strategy for further investigation as a future treatment

Principals of audit: Testing, data and ‘implicated advocacy’

Historically, school leaders have occupied a somewhat ambiguous position within networks of power. On the one hand, they appear to be celebrated as what Ball (2003) has termed the ‘new hero of educational reform’; on the other, they are often ‘held to account’ through those same performative processes and technologies. These have become compelling in schools and principals are ‘doubly bound’ through this. Adopting a Foucauldian notion of discursive production, this paper addresses the ways that the discursive ‘field’ of ‘principal’ (within larger regimes of truth such as schools, leadership, quality and efficiency) is produced. It explores how individual principals understand their roles and ethics within those practices of audit emerging in school governance, and how their self-regulation is constituted through NAPLAN – the National Assessment Program, Literacy and Numeracy. A key effect of NAPLAN has been the rise of auditing practices that change how education is valued. Open-ended interviews with 13 primary and secondary school principals from Western Australia, South Australia and New South Wales asked how they perceived NAPLAN's impact on their work, their relationships within their school community and their ethical practice

Radial Velocity Studies of Close Binary Stars. XV

Radial-velocity measurements and sine-curve fits to the orbital radial velocity variations are presented for the last eight close binary systems analyzed the same way as in the previous papers of this series: QX And, DY Cet, MR Del, HI Dra, DD Mon, V868 Mon, ER Ori, and Y Sex. For another seven systems (TT Cet, AA Cet, CW Lyn, V563 Lyr, CW Sge, LV Vir and MW Vir) phase coverage is insufficient to provide reliable orbits but radial velocities of individual components were measured. Observations of a few complicated systems observed throughout the DDO close-binary program are also presented; among them an especially interesting is the multiple system V857 Her which - in addition to the contact binary - very probably contains one or more sub-dwarf components of much earlier spectral type. All suspected binaries which were found to be most probably pulsating stars are briefly discussed in terms of mean radial velocities and projected rotation velocities (v sin i) as well as spectral type estimates. In two of them, CU CVn and V752 Mon, the broadening functions show a clear presence of non-radial pulsations. The previously missing spectral types for the DDO I paper are given here in addition to such estimates for most of the program stars of this paper.Comment: submitted to A

Radial Velocity Studies of Close Binary Stars.VI

Radial-velocity measurements and sine-curve fits to the orbital velocity variations are presented for the sixth set of ten close binary systems: SV Cam, EE Cet, KR Com, V410 Cyg, GM Dra, V972 Her, ET Leo, FS Leo, V2388 Oph, II UMa. All systems except FS Leo are double-lined spectroscopic binaries. The type of FS Leo is unknown while SV Cam is a close, detached binary; all remaining systems are contact binaries. Eight binaries (all except SV Cam and V401 Cyg) are the recent photometric discoveries of the Hipparcos satellite project. Five systems, EE Cet, KR Com, V401 Cyg, V2388 Oph, II UMa, are members of visual/spectroscopic triple systems. We were able to observe the close binary system EE Cet separately of its companion, but in the remaining four systems we could separate the spectral components only through the use of the broadening-function approach. Several of the studied systems are prime candidates for combined light and radial-velocity synthesis solutions.Comment: AASTeX5, 5 figures, 2 tables, modified after the AJ revie