On-Ground Calibration and Optical Alignment for the Orion Optical Navigation Camera

The Orion Multi-Purpose Crew Vehicle on-board Navigation System will utilize the Optical Navigation measurements of the Moon and Earth during cis-lunar operations. Misalignment or an un-calibrated optical navigation camera may cause large measurement residuals in any on-board attitude determination and navigation system. Therefore, a novel estimation technique to calibrate the internal camera parameters, and a high accuracy optical alignment procedure to estimate the external camera alignment are introduced in this paper. The intrinsic camera parameters such as the focal length, the principle point offsets, and the camera lens distortion parameters will be estimated and evaluated using images of star fields. This calibration estimation technique can be used either on-ground or in flight. The proposed technique in this paper is using the discrepancy between imaged star vectors attained from the OpNav camera, and the matched star vectors from the star catalog to determine the changes in internal camera parameters. This gave rise to the two basic types of calibration the attitude dependent and attitude independent methods. The former utilizes the errors in imaged and cataloged vectors themselves, and the latter using the discrepancy in angles between pairs of vectors from the camera and catalog. The alignment procedure is carried out using Theodolite autocollimator measurements taken off alignment cubes mounted on the Orion frame and also the measurements from the OpNav focal plane. It is assumed that the alignment cubes and OpNav camera are rigidly mounted to the frame so that flexing effects do not significantly alter the orientation of the cubes relative to the OpNav camera

Image Processing and Attitude Estimation Performance of Star Camera with Extended Bodies in the Field of View

To determine the attitude and the position of a spacecraft its orientation and location relative to some celestial reference frame must be defined. Attitude estimation is demonstrated with a star camera with extended bodies, such as a bright moon, in the field of view

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine

Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine

One Antarctic slug to confuse them all: the underestimated diversity of Doris kerguelenensis.

17 pagesInternational audienceThe Antarctic marine environment, although rich in life, is predicted to experience rapid and significant effects from climate change. Despite a revolution in the approaches used to document biodiversity, less than one percent of Antarctic marine invertebrates are represented by DNA barcodes and we are at risk of losing biodiversity before discovery. The ease of sequencing mitochondrial DNA barcodes has promoted this relatively ‘universal’ species identification system across most metazoan phyla and barcode datasets are currently readily used for exploring questions of species-level taxonomy. Here we present the most well-sampled phylogeny of the direct-developing, Southern Ocean nudibranch mollusc, Doris kerguelenensis to date. This study sampled over 1000 new Doris kerguelenensis specimens spanning the Southern Ocean and sequenced the mitochondrial COI gene. Results of a maximum likelihood phylogeny and multiple subsequent species delimitation analyses identified 27 new species in this complex (now 59 in total). Using rarefaction techniques, we infer more species are yet to be discovered. Some species were only collected from southern South America or the sub-Antarctic islands, while at least four species were found spanning the Polar Front. This is contrary to dispersal predictions for species without a larval stage such as Doris kerguelenensis. Our work demonstrates the value of increasing geographic scope in sampling and highlights what could be lost given the current global biodiversity crisis