Schematic representation of the decision-analysis model.

<p>Schematic representation of the decision-analysis model.</p

Results of base case analysis.

<p>Results of base case analysis.</p

Incremental outcomes and strategy selection frequency with the probabilistic sensitivity analysis using a Monte Carlo simulation.

<p>Incremental outcomes and strategy selection frequency with the probabilistic sensitivity analysis using a Monte Carlo simulation.</p

Summary of literature on mortality and progression to ESRD in CKD stage 4.

<p>*crude data in percentages, over 66 months of follow up.</p>†<p>crude 1 year data in percentages.</p>‡<p>Age-Standardized Rates.</p><p>PY: patient-years.</p><p>HMO: Health Maintenance Oraganization.</p

Probabilities and Utilities.

<p>Probabilities and Utilities.</p

Summary of literature on difference in mortality with CVC and AVF.

<p>*Adapted from Adjusted patient survival data.</p>†<p>Hazard ratio, compared to mortality with AVF.</p>‡<p>Six month follow up data.</p><p>PY: patient-years.</p

Two-way sensitivity analysis plotting rate of progression to dialysis and probability of steal: This demonstrates that the wait strategy results in a higher quality-adjusted life expectancy at lower rates of progression and lower probablility of ischemic steal and the AVF strategy results in a higher quality adjusted life expectancy at higher rates of progression of CKD to dialysis and higher rates of ischemic steal.

<p>Two-way sensitivity analysis plotting rate of progression to dialysis and probability of steal: This demonstrates that the wait strategy results in a higher quality-adjusted life expectancy at lower rates of progression and lower probablility of ischemic steal and the AVF strategy results in a higher quality adjusted life expectancy at higher rates of progression of CKD to dialysis and higher rates of ischemic steal.</p

Additional file 1: of Physical frailty and functional status in patients with advanced kidney disease: a protocol for a systematic review

Search strategy. The data provided shows the comprehensive search strategy for the MEDLINE database. (DOCX 14 kb

Additional file 3: of Quality metrics in solid organ transplantation: protocol for a systematic scoping review

The appraisal of candidate measures using the criteria for a good measure. The data provided demonstrates the tool that will be used to determine if a quality metric meets the criteria for a good measure. (DOCX 18.6 kb

Additional file 1: of Physical frailty and functional status in patients with advanced kidney disease: a protocol for a systematic review

Search strategy. The data provided shows the comprehensive search strategy for the MEDLINE database. (DOCX 14 kb