Implications of Variability Patterns observed in TeV Blazars on the Structure of the Inner Jet

The recent long look X-ray observations of TeV blazars have revealed many important new features concerning their time variability. In this paper, we suggest a physical interpretation for those features based on the framework of the internal and external shock scenarios. We present a simplified model applicable to TeV blazars, and investigate through simulations how each of the model parameters would affect to the observed light curve or spectrum. In particular, we show that the internal shock scenario naturally leads to all the observed variability properties including the structure function, but for it to be applicable, the fractional fluctuation of the initial bulk Lorentz factors must be small, with sigma_gamma / gamma_average < 0.01. This implies very low dynamical efficiency of the internal shock scenario. We also suggest that several observational quantities -- such as the characteristic time scale, the relative amplitude of flares as compared to the steady (``offset'') component, and the slope of the structure function -- can be used to probe the inner jet. The results are applied to the TeV blazar Mrk421, and this, within the context of the model, leads to the determination of several physical parameters: the ejection of a shell with average thickness of ~1E13 cm occurs on average every 10 minutes, and the shells collide ~1E17 cm away from the central source.Comment: 12 pages, 13 figures, to appear in Ap

Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers

Background: High-resolution magic angle spinning (HRMAS) NMR spectroscopy allows detailed metabolic analysis of whole biopsy samples for investigating tumour biology and tumour classification. Accurate biochemical assignment of small molecule metabolites that are “NMR visible” will improve our interpretation of HRMAS data and the translation of NMR tumour biomarkers to in-vivo studies. Results: 1D and 2D 1H HRMAS NMR was used to determine that 29 small molecule metabolites, along with 8 macromolecule signals, account for the majority of the HRMAS spectrum of the main types of brain tumour(astrocytoma grade II, grade III gliomas, glioblastomas, metastases, meningiomas and also lymphomas). Differences in concentration of 20 of these metabolites were statistically significant between these brain tumour types. During the course of an extended 2D data acquisition the HRMAS technique itself affects sample analysis: glycine, glutathione and glycerophosphocholine all showed small concentration changes; analysis of the sample after HRMAS indicated structural damage that may affect subsequent histopathological analysis. Conclusions: A number of small molecule metabolites have been identified as potential biomarkers of tumour type that may enable development of more selective in-vivo 1H NMR acquisition methods for diagnosis and prognosis of brain tumours

Radial Velocity Studies of Close Binary Stars. IX

Radial-velocity measurements and sine-curve fits to the orbital velocity variations are presented for the eighth set of ten close binary systems: AB And, V402 Aur, V445 Cep, V2082 Cyg, BX Dra, V918 Her, V502 Oph, V1363 Ori, KP Peg, V335 Peg. Half of the systems (V445 Cep, V2082 Cyg, V918 Her, V1363 Ori, V335 Peg) were discovered photometrically by the Hipparcos mission and all systems are double-lined (SB2) contact binaries. The broadening function method permitted improvement of the orbital elements for AB And and V502 Oph. The other systems have been observed for radial velocity variations for the first time; in this group are five bright (V<7.5) binaries: V445 Cep, V2082 Cyg, V918 Her, KP Peg and V335 Peg. Several of the studied systems are prime candidates for combined light and radial-velocity synthesis solutions.Comment: 17+ pages, 2 tables, 4 figure

A Planet at 5 AU Around 55 Cancri

We report precise Doppler shift measurements of 55 Cancri (G8V) obtained from 1989 to 2002 at Lick Observatory. The velocities reveal evidence for an outer planetary companion to 55 Cancri orbiting at 5.5 AU. The velocities also confirm a second, inner planet at 0.11 AU. The outer planet is the first extrasolar planet found that orbits near or beyond the orbit of Jupiter. It was drawn from a sample of ~50 stars observed with sufficient duration and quality to detect a giant planet at 5 AU, implying that such planets are not rare. The properties of this jupiter analog may be compared directly to those of the Jovian planets in our Solar System. Its eccentricity is modest, e=0.16, compared with e=0.05 for both Jupiter and Saturn. Its mass is at least 4.0 jupiter masses (M sin i). The two planets do not perturb each other significantly. Moreover, a third planet of sub-Jupiter mass could easily survive in between these two known planets. Indeed a third periodicity remains in the velocity measurements with P = 44.3 d and a semi-amplitude of 13 m/s. This periodicity is caused either by a third planet at a=0.24 AU or by inhomogeneities on the stellar surface that rotates with period 42 d. The planet interpretation is more likely, as the stellar surface is quiet, exhibiting log(R'_{HK}) = -5.0 and brightness variations less than 1 millimag, and any hypothetical surface inhomogeneity would have to persist in longitude for 14 yr. Even with all three planets, an additional planet of terrestrial--mass could orbit stably at ~1 AU. The star 55 Cancri is apparently a normal, middle-aged main sequence star with a mass of 0.95 solar masses, rich in heavy elements ([Fe/H] = +0.27). This high metallicity raises the issue of the relationship between its age, rotation, and chromosphere.Comment: 47 pages, 4 tables, 12 figures, uses AASTE

A vortex description of the first-order phase transition in type-I superconductors

Using both analytical arguments and detailed numerical evidence we show that the first order transition in the type-I 2D Abelian Higgs model can be understood in terms of the statistical mechanics of vortices, which behave in this regime as an ensemble of attractive particles. The well-known instabilities of such ensembles are shown to be connected to the process of phase nucleation. By characterizing the equation of state for the vortex ensemble we show that the temperature for the onset of a clustering instability is in qualitative agreement with the critical temperature. Below this point the vortex ensemble collapses to a single cluster, which is a non-extensive phase, and disappears in the absence of net topological charge. The vortex description provides a detailed mechanism for the first order transition, which applies at arbitrarily weak type-I and is gauge invariant unlike the usual field-theoretic considerations, which rely on asymptotically large gauge coupling.Comment: 4 pages, 6 figures, uses RevTex. Additional references added, some small corrections to the tex

“Top-Down-Bottom-Up” Methodology as a Common Approach to Defining Bespoke Sets of Sustainability Assessment Criteria for the Built Environment

YesThe top-down-bottom-up (TDBU) methodology for defining bespoke sets of sustainability criteria for specific civil engineering project types is introduced and discussed. The need to define sustainability criteria for specific civil engineering project types occurs mainly in one or both of the following cases: (1) when a more comprehensive and indicative assessment of the sustainability of the project type in question is required; and/or (2) there is no readily available bespoke sustainability assessment tool, or set of criteria, for assessing the sustainability of the project type. The construction of roads, buildings, airports, tunnels, dams, flood banks, bridges, water supply, and sewage systems and their supporting systems are considered to be unique civil engineering/infrastructure project types. The normative definition of sustainable civil engineering/infrastructure projects and the framework for assessing its sustainability is defined and provided by the authors. An example of the TDBU methodology being applied to define sustainability criteria for transport noise reducing devices is presented and discussed. The end result of applying the methodology is a systematically researched and industry validated set of criteria that denotes assessing the sustainability of the civil engineering/infrastructure project type. The paper concludes that the top-down-bottom-up will support stakeholders and managers involved in assessing sustainability to consider all major research methods to define general and unique sustainability criteria to assess and so maximize sustainability

Eight common genetic variants associated with serum dheas levels suggest a key role in ageing mechanisms

Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10-36), SULT2A1 (rs2637125; p = 2.61×10-19), ARPC1A (rs740160; p = 1.56×10-16), TRIM4 (rs17277546; p = 4.50×10-11), BMF (rs7181230; p = 5.44×10-11), HHEX (rs2497306; p = 4.64×10-9), BCL2L11 (rs6738028; p = 1.72×10-8), and CYP2C9 (rs2185570; p = 2.29×10-8). These genes are associated with type 2 diabetes, lymphoma, actin filament assembly, drug and xenobiotic metabolism, and zinc finger proteins. Several SNPs were associated with changes in gene expression levels, and the related genes are connected to biological pathways linking DHEAS with ageing. This study provides much needed insight into the function of DHEAS

Beta Dips in the Gaia Era: Simulation Predictions of the Galactic Velocity Anisotropy Parameter (β) for Stellar Halos

The velocity anisotropy parameter, β, is a measure of the kinematic state of orbits in the stellar halo, which holds promise for constraining the merger history of the Milky Way (MW). We determine global trends for β as a function of radius from three suites of simulations, including accretion-only and cosmological hydrodynamic simulations. We find that the two types of simulations are consistent and predict strong radial anisotropy ($\langle \beta \rangle \sim 0.7$) for Galactocentric radii greater than 10 kpc. Previous observations of β for the MW's stellar halo claim a detection of an isotropic or tangential "dip" at r ~ 20 kpc. Using the N-body+SPH simulations, we investigate the temporal persistence, population origin, and severity of "dips" in β. We find that dips in the in situ stellar halo are long-lived, while dips in the accreted stellar halo are short-lived and tied to the recent accretion of satellite material. We also find that a major merger as early as z ~ 1 can result in a present-day low (isotropic to tangential) value of β over a broad range of radii and angles. While all of these mechanisms are plausible drivers for the β dip observed in the MW, each mechanism in the simulations has a unique metallicity signature associated with it, implying that future spectroscopic surveys could distinguish between them. Since an accurate knowledge of β(r) is required for measuring the mass of the MW halo, we note that significant transient dips in β could cause an overestimate of the halo's mass when using spherical Jeans equation modeling