Crafting divine personae in Julian’s Oration 7

Peer reviewedPublisher PD

‘Ammianus, Julian, and the Fate of George’s Library’

Peer reviewedPublisher PD

New Testament Christology, Athanasian Apologetic, and Pagan Polemic

Peer reviewedPostprin

Plato’s Pilot in the Political Strategy of Julian and Libanius

Peer reviewedPostprin

A reliability-aware chance-constrained battery sizing method for island microgrid

Island Microgrids can coordinate local energy resources, provide post-fault reliability improvements for local customers, and aggregate local power and energy resources to offer services to the wider system. A crucial component of an Island Microgrid is the battery energy storage system, which can manage local imbalances, alleviate constraints, and improve reliability by enabling post-fault islanding. A planning and sizing method is required to quantify and maximize the benefits of battery energy storage while avoiding over-investment and under-utilization. This paper combines comprehensive reliability assessment with chance-constrained convex optimization, via second-order cone programming, to optimally size energy storage within an Island Microgrid. Chance constraints are applied to the battery state-of-charge to avoid sizing the energy storage to accommodate extreme cases of uncertainty, avoiding uneconomic investment. The probability of reaching a state-of-charge constraint also indicates the likelihood that the battery energy storage system will be unable to facilitate island operation in the event of an outage, which affects the Island Microgrid reliability. The method is demonstrated on a real Austrian distribution network as part of the MERLON project. Results illustrate that an optimal trade-off can be identified between system reliability and operating cost when the probability of violating the chance constraints is 4.8%

Fiction Fix 07

https://digitalcommons.unf.edu/fiction_fix/1006/thumbnail.jp

Optimization of Fuzzy Energy-Management System for Grid-Connected Microgrid Using NSGA-II

This article proposes a fuzzy logic-based energy-management system (FEMS) for a grid-connected microgrid with renewable energy sources (RESs) and energy storage system (ESS). The objectives of the FEMS are reducing the average peak load (APL) and operating cost through arbitrage operation of the ESS. These objectives are achieved by controlling the charge and discharge rate of the ESS based on the state of charge of ESS, the power difference between load and RES, and electricity market price. The effectiveness of the fuzzy logic greatly depends on the membership functions (MFs). The fuzzy MFs of the FEMS are optimized offline using a Pareto-based multiobjective evolutionary algorithm, nondominated sorting genetic algorithm (NSGA-II). The best compromise solution is selected as the final solution and implemented in the fuzzy-logic controller. A comparison with other control strategies with similar objectives is carried out at a simulation level. The proposed FEMS is experimentally validated on a real microgrid in the energy storage test bed at Newcastle University, U.K

Is There an Association between Advanced Paternal Age and Endophenotype Deficit Levels in Schizophrenia?

The children of older fathers have increased risks of developing schizophrenia spectrum disorders, and among those who develop these disorders, those with older fathers present with more severe clinical symptoms. However, the influence of advanced paternal age on other important domains related to schizophrenia, such as quantitative endophenotype deficit levels, remains unknown. This study investigated the associations between paternal age and level of endophenotypic impairment in a well-characterized family-based sample from the Consortium on the Genetics of Schizophrenia (COGS). All families included at least one affected subject and one unaffected sibling. Subjects met criteria for schizophrenia (probands; n = 293) or were unaffected first-degree siblings of those probands (n = 382). Paternal age at the time of subjects’ birth was documented. Subjects completed a comprehensive clinical assessment and a battery of tests that measured 16 endophenotypes. After controlling for covariates, potential paternal age–endophenotype associations were analyzed using one model that included probands alone and a second model that included both probands and unaffected siblings. Endophenotype deficits in the Identical Pairs version of the 4-digit Continuous Performance Test and in the Penn Computerized Neurocognitive Battery verbal memory test showed significant associations with paternal age. However, after correcting for multiple comparisons, no endophenotype was significantly associated with paternal age. These findings suggest that factors other than advanced paternal age at birth may account for endophenotypic deficit levels in schizophrenia

Modelling the impact of intermittent preventive treatment for malaria on selection pressure for drug resistance

BACKGROUND: Intermittent preventive treatment (IPT) is a promising intervention for malaria control, although there are concerns about its impact on drug resistance. METHODS: The key model inputs are age-specific values for a) baseline anti-malarial dosing rate, b) parasite prevalence, and c) proportion of those treated with anti-malarials (outside IPT) who are infected. These are used to estimate the immediate effect of IPT on the genetic coefficient of selection (s). The scenarios modelled were year round IPT to infants in rural southern Tanzania, and three doses at monthly intervals of seasonal IPT in Senegal. RESULTS: In the simulated Tanzanian setting, the model suggests a high selection pressure for drug resistance, but that IPTi would only increase this by a small amount (4.4%). The percent change in s is larger if parasites are more concentrated in infants, or if baseline drug dosing is less common or less specific. If children aged up to five years are included in the Tanzanian scenario then the predicted increase in s rises to 31%. The Senegalese seasonal IPT scenario, in children up to five years, results in a predicted increase in s of 16%. CONCLUSION: There is a risk that the useful life of drugs will be shortened if IPT is implemented over a wide childhood age range. On the other hand, IPT delivered only to infants is unlikely to appreciably shorten the useful life of the drug used

Association Analysis of 94 Candidate Genes and Schizophrenia-Related Endophenotypes

While it is clear that schizophrenia is highly heritable, the genetic basis of this heritability is complex. Human genetic, brain imaging, and model organism studies have met with only modest gains. A complementary research tactic is to evaluate the genetic substrates of quantitative endophenotypes with demonstrated deficits in schizophrenia patients. We used an Illumina custom 1,536-SNP array to interrogate 94 functionally relevant candidate genes for schizophrenia and evaluate association with both the qualitative diagnosis of schizophrenia and quantitative endophenotypes for schizophrenia. Subjects included 219 schizophrenia patients and normal comparison subjects of European ancestry and 76 schizophrenia patients and normal comparison subjects of African ancestry, all ascertained by the UCSD Schizophrenia Research Program. Six neurophysiological and neurocognitive endophenotype test paradigms were assessed: prepulse inhibition (PPI), P50 suppression, the antisaccade oculomotor task, the Letter-Number Span Test, the California Verbal Learning Test-II, and the Wisconsin Card Sorting Test-64 Card Version. These endophenotype test paradigms yielded six primary endophenotypes with prior evidence of heritability and demonstrated schizophrenia-related impairments, as well as eight secondary measures investigated as candidate endophenotypes. Schizophrenia patients showed significant deficits on ten of the endophenotypic measures, replicating prior studies and facilitating genetic analyses of these phenotypes. A total of 38 genes were found to be associated with at least one endophenotypic measure or schizophrenia with an empirical p-value<0.01. Many of these genes have been shown to interact on a molecular level, and eleven genes displayed evidence for pleiotropy, revealing associations with three or more endophenotypic measures. Among these genes were ERBB4 and NRG1, providing further support for a role of these genes in schizophrenia susceptibility. The observation of extensive pleiotropy for some genes and singular associations for others in our data may suggest both converging and independent genetic (and neural) pathways mediating schizophrenia risk and pathogenesis