Observing the sky at extremely high energies with the Cherenkov Telescope Array: Status of the GCT project

The Cherenkov Telescope Array is the main global project of ground-based gamma-ray astronomy for the coming decades. Performance will be significantly improved relative to present instruments, allowing a new insight into the high-energy Universe [1]. The nominal CTA southern array will include a sub-array of seventy 4 m telescopes spread over a few square kilometers to study the sky at extremely high energies, with the opening of a new window in the multi-TeV energy range. The Gamma-ray Cherenkov Telescope (GCT) is one of the proposed telescope designs for that sub-array. The GCT prototype recorded its first Cherenkov light on sky in 2015. After an assessment phase in 2016, new observations have been performed successfully in 2017. The GCT collaboration plans to install its first telescopes and cameras on the CTA site in Chile in 2018-2019 and to contribute a number of telescopes to the subsequent CTA production phase.Comment: 8 pages, 7 figures, ICRC201

Defending America by Aiding the Allies: The British Student Pilots at Arcadia and Clewiston, 1941-1945

Monday morning, June 8, 1941, 99 British citizens arrived at the Atlantic Coast Line depot in Arcadia, Florida. Although dressed in civilian clothes, all were members of the Royal Air Force destined for training as pilots in the United States before returning to defend king and country in the raging European war. It was a delicate situation. The United States was trying to aid Britain and her allies while maintaining its official neutrality

Determining the efficacy of a biosensor to detect calpastatin, a meat tenderness indicator

The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.Title from title screen of research.pdf file (viewed on September 18, 2007)Vita.Thesis (Ph. D.) University of Missouri-Columbia 2007.An instrumental tenderness detection system used at the time of grading to sort beef carcasses on their predicted tenderness would be valuable for the beef industry. A biosensor to accurately predict calpastatin, the inhibitor of the enzyme responsible for increased tenderness due to aging, has been investigated as a detection system. Longissimus dorsi samples from between the 12th and 13th rib of the beef carcass (n = 21 and n = 11) were extracted at 0, 24, 36 and 48 h postmortem for trial one and at 0 and 48 hr for trial two. These samples were assayed for calpastatin by traditional laboratory methods and with the developed biosensors. The biosensor used in trial one was an optical fiber and trial two was a capillary tube. Warner-Bratzler shear force was also performed on a steak from each carcass. In trial one, correlations were generated from each sampling period to determine the most closely correlated sampling times between the traditional assay and the biosensor. The highest correlations between the calpastatin and optical fiber were taken at 48 hr postmortem, suggesting that this is the best time for use of the biosensor in an online grading system. The correlation was lower for the capillary tube but there was less variation in the 0 hr capillary tube than the 0 hr precolumn and post-column optical fiber, therefore this is a more promising system. This research further advances the development of the biosensor and makes online assessment of calpastatin one step closer to reality.Includes bibliographical reference

Aberrant posterior cingulate connectivity classify first-episode schizophrenia from controls: A machine learning study

Background Posterior cingulate cortex (PCC) is a key aspect of the default mode network (DMN). Aberrant PCC functional connectivity (FC) is implicated in schizophrenia, but the potential for PCC related changes as biological classifier of schizophrenia has not yet been evaluated. Methods We conducted a data-driven approach using resting-state functional MRI data to explore differences in PCC-based region- and voxel-wise FC patterns, to distinguish between patients with first-episode schizophrenia (FES) and demographically matched healthy controls (HC). Discriminative PCC FCs were selected via false discovery rate estimation. A gradient boosting classifier was trained and validated based on 100 FES vs. 93 HC. Subsequently, classification models were tested in an independent dataset of 87 FES patients and 80 HC using resting-state data acquired on a different MRI scanner. Results Patients with FES had reduced connectivity between PCC and frontal areas, left parahippocampal regions, left anterior cingulate cortex, and right inferior parietal lobule, but hyperconnectivity with left lateral temporal regions. Predictive voxel-wise clusters were similar to region-wise selected brain areas functionally connected with PCC in relation to discriminating FES from HC subject categories. Region-wise analysis of FCs yielded a relatively high predictive level for schizophrenia, with an average accuracy of 72.28% in the independent samples, while selected voxel-wise connectivity yielded an accuracy of 68.72%. Conclusion FES exhibited a pattern of both increased and decreased PCC-based connectivity, but was related to predominant hypoconnectivity between PCC and brain areas associated with DMN, that may be a useful differential feature revealing underpinnings of neuropathophysiology for schizophrenia

Neural Connectivity Underlying Reward and Emotion-Related Processing : Evidence From a Large-Scale Network Analysis

This work was supported by grants from the Economic and Social Research Council (ES/K013424/1) and the Leverhulme Trust (RPG-2019-010).Peer reviewedPublisher PD

Tagging High Energy Photons in the H1 Detector at HERA

Measures taken to extend the acceptance of the H1 detector at HERA for photoproduction events are described. These will enable the measurement of electrons scattered in events in the high y range 0.85 < y < 0.95 in the 1998 and 1999 HERA run period. The improvement is achieved by the installation of an electromagnetic calorimeter, the ET8, in the HERA tunnel close to the electron beam line 8 m downstream of the H1 interaction point in the electron direction. The ET8 will allow the study of tagged gamma p interactions at centre-of-mass energies significantly higher than those previously attainable. The calorimeter design and expected performance are discussed, as are results obtained using a prototype placed as close as possible to the position of the ET8 during the 1996 and 1997 HERA running.Comment: 13 pages, 13 figure