Penile traction therapy in Peyronie's disease

Penile traction therapy has traditionally been implemented to increase penile length but has recently been investigated for reducing the curvature associated with Peyronie's disease. The results of a few initial investigations have been conflicting, and further research is needed to confirm the true benefit of such therapy and its potential role in treating Peyronie's disease as both a monotherapy and in combination with other therapeutic options

Externalities from Alcohol Consumption in the 2005 US National Alcohol Survey: Implications for Policy

A subsample (n = 2,550) of the 2005 US National Alcohol Survey of adults was used to estimate prevalence and correlates of six externalities from alcohol abuse––family problems, assaults, accompanying intoxicated driver, vehicular accident, financial problems and vandalized property––all from another’s drinking. On a lifetime basis, 60% reported externalities, with a lower 12-month rate (9%). Women reported more family/marital and financial impacts and men more assaults, accompanying drunk drivers, and accidents. Being unmarried, older, white and ever having monthly heavy drinking or alcohol problems was associated with more alcohol externalities. Publicizing external costs of drinking could elevate political will for effective alcohol controls

The State of Digital Media Data Research, 2024

The purpose of this report is to reflect on the state of digital media data research in 2024. This is the second in a series of reports on the state of digital media research, which we originally published in 2023. We reflect on changes to digital media research since our report in 2023. Specifically, we highlight the following trends: 1. From 2023 to 2024, access to digital media data changed drastically. Researchers were largely priced out of the Twitter API, and Pushshift–a commonly used archive for Reddit data–went private to comply with Reddit’s API policies. Meta also announced the imminent sunsetting of CrowdTangle, a transparency tool popular amongst researchers and journalists alike. At the same time, however, many platforms announced academic programs for data access, including the YouTube researcher program, TikTok’s Research API, and the Meta Content Library. 2. Federated social media platforms became more popular. Following Elon Musk’s purchase of Twitter, Twitter users flocked to Mastodon, Threads, BlueSky, and other federated (or soon to be federated) platforms. This presents unique challenges for researchers studying digital media data. As new platforms are created, researchers must build new tools to analyze them or wait for third parties or the platforms themselves to make data available. 3. Generative AI’s explosion may change how we study digital media. First, researchers using computational methods to measure social media content have turned to OpenAI’s ChatGPT and other Large Language Models (LLMs) to classify content. Second, researchers and civil society groups are increasingly concerned about the possibility for Generative AI to flood the information environment with fake content. 4. In February 2024, the EU Digital Services Act (DSA) went into effect, mandating that large platforms give researchers near real-time access to public data. We don’t yet know how these policies will impact data access in the United States, and it remains unclear what this data access will look like in practice. In the United States, legislative efforts to mandate researcher access stalled. While the last year brought many welcome and unwelcome changes to digital media data research, the findings in this report renew our encouragement that digital media data research should be guided by collaboration, transparency, preparation, and consistency.Journalism and Medi

Linking Urban Tree Cover Change and Local History in a Post-Industrial City

Municipal leaders are pursuing ambitious goals to increase urban tree canopy (UTC), but there is little understanding of the pace and socioecological drivers of UTC change. We analyzed land cover change in Philadelphia, Pennsylvania (United States) from 1970–2010 to examine the impacts of post-industrial processes on UTC. We interpreted land cover classes using aerial imagery and assessed historical context using archival newspapers, agency reports, and local historical scholarship. There was a citywide UTC increase of +4.3 percentage points. Substantial UTC gains occurred in protected open spaces related to both purposeful planting and unintentional forest emergence due to lack of maintenance, with the latter phenomenon well-documented in other cities located in forested biomes. Compared to developed lands, UTC was more persistent in protected open spaces. Some neighborhoods experienced substantial UTC gains, including quasi-suburban areas and depopulated low-income communities; the latter also experienced decreasing building cover. We identified key processes that drove UTC increases, and which imposed legacies on current UTC patterns: urban renewal, urban greening initiatives, quasi-suburban developments, and (dis)investments in parks. Our study demonstrates the socioecological dynamism of intra-city land cover changes at multi-decadal time scales and the crucial role of local historical context in the interpretation of UTC change

Implementing automated pCO2 control in small scale cell culture models

High carbon dioxide levels observed during scale up of a mammalian cell culture process were found to impact glycan levels of a monoclonal antibody. Small scale bioreactor and shake flask models were developed to achieve the high pCO2 levels and profiles observed at large scale for process understanding studies. The precise reproduction of pCO2 profiles in small scale models can be challenging, due to use of manual controls and to potential impact of high pCO2 levels on other process parameters and quality attributes. For improved control, automation was applied to bench scale stirred tank bioreactors using an online pCO2 probe and to ambr® 250 disposable bioreactors using an off-gas analyzer. Design of the automated CO2 control strategy in these small scale bioreactor systems will be presented

The insurance landscape for implant- and autologous-based breast reconstruction in the United States

UNLABELLED: Insurance coverage of postmastectomy breast reconstruction is mandated in America, regardless of reconstructive modality. Despite enhanced patient-reported outcomes, autologous reconstruction is utilized less than nonautologous reconstruction nationally. Lower reimbursement from Medicare and Medicaid may disincentivize autologous-based reconstruction. This study examines the impact of insurance and sociodemographic factors on breast reconstruction. METHODS: A retrospective analysis of the Healthcare Cost and Utilization Project National Inpatient Sample Database from 2014 to 2017 was performed. International Classification of Diseases Clinical Modification and Procedure Coding System codes were used to identify patients for inclusion. De-identified sociodemographic and insurance data were analyzed using RESULTS: In total, 31,468 patients were identified for analysis and stratified by reconstructive modality, sociodemographics, insurance, and hospital characteristics. Most patients underwent nonautologous reconstruction (63.2%). Deep inferior epigastric perforator flaps were the most common autologous modality (46.7%). Least absolute shrinkage and selection operator regression identified Black race, urban-teaching hospitals, nonsmoking status, and obesity to be associated with autologous reconstruction. Publicly-insured patients were less likely to undergo autologous reconstruction than privately-insured patients. Within autologous reconstruction, publicly-insured patients were 1.97 ( CONCLUSIONS: Breast reconstruction is influenced by insurance, hospital demographics, and sociodemographic factors. Action to mitigate this health disparity should be undertaken so that surgical decision-making is solely dependent upon medical and anatomic factors

Field applications of the second-generation Environmental Sample Processor (ESP) for remote detection of harmful algae: 2006-2007

We assess the application of the second-generation Environmental Sample Processor (ESP) for the detection of harmful algal bloom (HAB) species in field and laboratory settings using two molecular probe techniques: a sandwich hybridization assay (SHA) and fluorescent in situ hybridization (FISH). During spring 2006, the first time this new instrument was deployed, the ESP successfully automated application of DNA probe arrays for various HAB species and other planktonic taxa, but non-specific background binding on the SHA probe array support made results interpretation problematic. Following 2006, the DNA array support membrane that we were using was replaced with a different membrane, and the SHA chemistry was adjusted. The sensitivity and dynamic range of these modifications were assessed using 96-well plate and ESP array SHA formats for several HAB species found commonly in Monterey Bay over a range of concentrations; responses were significantly correlated (p < 0.01). Modified arrays were deployed in 2007. Compared to 2006, probe arrays showed improved signal:noise, and remote detection of various HAB species was demonstrated. We confirmed that the ESP and affiliated assays can detect HAB populations at levels below those posing human health concerns, and results can be related to prevailing environmental conditions in near real-time

A Reverse Approach to Named Entity Extraction and Linking in Microposts

ABSTRACT In this paper, we present a pipeline for named entity extraction and linking that is designed specifically for noisy, grammatically inconsistent domains where traditional named entity techniques perform poorly. Our approach leverages a large knowledge base to improve entity recognition, while maintaining the use of traditional NER to identify mentions that are not co-referent with any entities in the knowledge base

The Drinker’s Effect on the Social Environment: A Conceptual Framework for Studying Alcohol’s Harm to Others

The paper considers conceptual and methodological issues in studying the scope of alcohol’s harm to others. Reasons are suggested for the relative neglect of the topic. The approaches in two relevant research traditions are considered: population surveys on alcohol problems, and economic cost of alcohol studies. Ways of conceptualizing and measuring aspects of the drinker’s effects on others are considered, in terms of main types of relationship with the other, and in terms of major societal response institutions. The main types of data tend to measure different levels of severity, with population survey data dominated by less severe problems, and response institution data by more severe problems; so both are needed for a three-dimensional view. Research questions for the field and its policy significance are noted

A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma

Tumors are capable of coopting hematopoietic cells to create a suitable microenvironment to support malignant growth. Here, we have demonstrated that upregulation of kinase insert domain receptor (KDR), also known as VEGFR2, in a myeloid cell sublineage is necessary for malignant progression of gliomas in transgenic murine models and is associated with high-grade tumors in patients. KDR expression increased in myeloid cells as myeloid-derived suppressor cells (MDSCs) accumulated, which was associated with the transformation and progression of low-grade fibrillary astrocytoma to high-grade anaplastic gliomas. KDR deficiency in murine BM-derived cells (BMDCs) suppressed the differentiation of myeloid lineages and reduced granulocytic/monocytic populations. The depletion of myeloid-derived KDR compromised its proangiogenic function, which inhibited the angiogenic switch necessary for malignant progression of low-grade to high-grade tumors. We also identified inhibitor of DNA binding protein 2 (ID2) as a key upstream regulator of KDR activation during myeloid differentiation. Deficiency of ID2 in BMDCs led to downregulation of KDR, suppression of proangiogenic myeloid cells, and prevention of low-grade to high-grade transition. Tumor-secreted TGF-β and granulocyte-macrophage CSF (GM-CSF) enhanced the KDR/ID2 signaling axis in BMDCs. Our results suggest that modulation of KDR/ID2 signaling may restrict tumor-associated myeloid cells and could potentially be a therapeutic strategy for preventing transformation of premalignant gliomas.This study was supported by the Department of Defense Con- gressionally Directed Medical Research Programs (DOD CDMRP, CA120318 to Y. Huang), Elizabeth’s Hope (J. Greenfield), the Starr Foundation, the Paduano Foundation, the Champalimaud Foun- dation, the Malcolm Hewitt Wiener Foundation, the POETIC Foundation, the Sohn Foundation, the Hartwell Foundation, and the Children’s Cancer and Blood Foundation (all to D. Lyden). Address correspondence to: David Lyden, Department of Pediatrics, Weill Medical Medicine, 413 E. 69th Street, Box 284, New York, New York 10021, USA. Phone: 646.962.6238; E-mail: [email protected]. Or to: Jeffrey P. Greenfield, Department of Neurological Surgery, Weill Cornell Medicine, 525 E 68th Street, Box 99, New York, New York 10065, USA. Phone: 212.746.2363; E-mail: [email protected]. HP’s present address is: Microenvironment and Metastasis Group, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.S