Localized Tachyons and the g_cl conjecture

We consider C/Z_N and C^2/Z_N orbifolds of heterotic string theories and Z_N orbifolds of AdS_3. We study theories with N=2 worldsheet superconformal invariance and construct RG flows. Following Harvey, Kutasov, Martinec and Moore, we compute g_cl and show that it decreases monotonically along RG flows- as conjectured by them. For the heterotic string theories, the gauge degrees of freedom do not contribute to the computation of g_cl.Comment: Corrections and clarifications made, 19 page

Twistfield Perturbations of Vertex Operators in the Z_2-Orbifold Model

We apply Kadanoff's theory of marginal deformations of conformal field theories to twistfield deformations of Z_2 orbifold models in K3 moduli space. These deformations lead away from the Z_2 orbifold sub-moduli-space and hence help to explore conformal field theories which have not yet been understood. In particular, we calculate the deformation of the conformal dimensions of vertex operators for p^2<1 in second order perturbation theory.Comment: Latex2e, 19 pages, 1 figur

Domestic Rivalry and Export Performance: Theory and Evidence from International Airline Markets

The much-studied relationship between domestic rivalry and export performance consists of those supporting a national-champion rationale, and those supporting a rivalry rationale. While the empirical literature generally supports the positive effects of domestic rivalry, the national-champion rationale actually rests on firmer theoretical ground. We address this inconsistency by providing a theoretical framework that illustrates three paths via which domestic rivalry translates into enhanced international exports. Furthermore, empirical tests on the world airline industry elicit the existence of one particular path - an enhanced firm performance effect - that connects domestic rivalry with improved international exports

Family Unification in Five and Six Dimensions

In family unification models, all three families of quarks and leptons are grouped together into an irreducible representation of a simple gauge group, thus unifying the Standard Model gauge symmetries and a gauged family symmetry. Large orthogonal groups, and the exceptional groups $E_7$ and $E_8$ have been much studied for family unification. The main theoretical difficulty of family unification is the existence of mirror families at the weak scale. It is shown here that family unification without mirror families can be realized in simple five-dimensional and six-dimensional orbifold models similar to those recently proposed for SU(5) and SO(10) grand unification. It is noted that a family unification group that survived to near the weak scale and whose coupling extrapolated to high scales unified with those of the Standard model would be evidence accessible in principle at low energy of the existence of small (Planckian or GUT-scale) extra dimensions.Comment: 13 pages, 2 figures, minor corrections, references adde

An Effect of α′\alpha' Corrections on Racetrack Inflation

We study the effects of $\alpha '$ corrections to the K\"ahler potential on volume stabilisation and racetrack inflation. In a region where classical supergravity analysis is justified, stringy corrections can nevertheless be relevant for correctly analyzing moduli stabilisation and the onset of inflation.Comment: 13 pages, 4 figures. Typos corrected, references added, this version to appear in JHE

Affine and toric hyperplane arrangements

We extend the Billera-Ehrenborg-Readdy map between the intersection lattice and face lattice of a central hyperplane arrangement to affine and toric hyperplane arrangements. For arrangements on the torus, we also generalize Zaslavsky's fundamental results on the number of regions.Comment: 32 pages, 4 figure

Towards a Stringy Resolution of the Cosmological Singularity

We study cosmological solutions to the low-energy effective action of heterotic string theory including possible leading order $\alpha'$ corrections and a potential for the dilaton. We consider the possibility that including such stringy corrections can resolve the initial cosmological singularity. Since the exact form of these corrections is not known the higher-derivative terms are constructed so that they vanish when the metric is de Sitter spacetime. The constructed terms are compatible with known restrictions from scattering amplitude and string worldsheet beta-function calculations. Analytic and numerical techniques are used to construct a singularity-free cosmological solution. At late times and low-curvatures the metric is asymptotically Minkowski and the dilaton is frozen. In the high-curvature regime the universe enters a de Sitter phase.Comment: 6 pages, 2 Figures; minor revisions; references added; REVTeX 4; version to appear in Phys. Rev.

Four Dimensional String/String/String Triality

In six spacetime dimensions, the heterotic string is dual to a Type $IIA$ string. On further toroidal compactification to four spacetime dimensions, the heterotic string acquires an SL(2,\BbbZ)_S strong/weak coupling duality and an SL(2,\BbbZ)_T \times SL(2,\BbbZ)_U target space duality acting on the dilaton/axion, complex Kahler form and the complex structure fields $S,T,U$ respectively. Strong/weak duality in $D=6$ interchanges the roles of $S$ and $T$ in $D=4$ yielding a Type $IIA$ string with fields $T,S,U$. This suggests the existence of a third string (whose six-dimensional interpretation is more obscure) that interchanges the roles of $S$ and $U$. It corresponds in fact to a Type $IIB$ string with fields $U,T,S$ leading to a four-dimensional string/string/string triality. Since SL(2,\BbbZ)_S is perturbative for the Type $IIB$ string, this $D=4$ triality implies $S$-duality for the heterotic string and thus fills a gap left by $D=6$ duality. For all three strings the total symmetry is SL(2,\BbbZ)_S \times O(6,22;\BbbZ)_{TU}. The O(6,22;\BbbZ) is {\it perturbative} for the heterotic string but contains the conjectured {\it non-perturbative} SL(2,\BbbZ)_X, where $X$ is the complex scalar of the $D=10$ Type $IIB$ string. Thus four-dimensional triality also provides a (post-compactification) justification for this conjecture. We interpret the $N=4$ Bogomol'nyi spectrum from all three points of view. In particular we generalize the Sen-Schwarz formula for short multiplets to include intermediate multiplets also and discuss the corresponding black hole spectrum both for the $N=4$ theory and for a truncated $S$--$T$--$U$ symmetric $N=2$ theory. Just as the first two strings are described by the four-dimensional {\it elementary} and {\it dual solitonic} solutions, so theComment: 36 pages, Latex, 2 figures, some references changed, minor changes in formulas and tables; to appear in Nucl. Phys.

Mirror Manifolds in Higher Dimension

We describe mirror manifolds in dimensions different from the familiar case of complex threefolds. We emphasize the simplifying features of dimension three and supply more robust methods that do not rely on such special characteristics and hence naturally generalize to other dimensions. The moduli spaces for Calabi--Yau $d$-folds are somewhat different from the ``special K\"ahler manifolds'' which had occurred for $d=3$, and we indicate the new geometrical structures which arise. We formulate and apply procedures which allow for the construction of mirror maps and the calculation of order-by-order instanton corrections to Yukawa couplings. Mathematically, these corrections are expected to correspond to calculating Chern classes of various parameter spaces (Hilbert schemes) for rational curves on Calabi--Yau manifolds. Our results agree with those obtained by more traditional mathematical methods in the limited number of cases for which the latter analysis can be carried out. Finally, we make explicit some striking relations between instanton corrections for various Yukawa couplings, derived from the associativity of the operator product algebra.Comment: 44 pages plus 3 tables using harvma

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin–proteasome system (UPS) for widespread degradation of outer membrane proteins. This is evidenced by an increase in K48-linked polyubiquitin on mitochondria, recruitment of the 26S proteasome and rapid degradation of multiple outer membrane proteins. The degradation of proteins by the UPS occurs independently of the autophagy pathway, and inhibition of the 26S proteasome completely abrogates Parkin-mediated mitophagy in HeLa, SH-SY5Y and mouse cells. Although the mitofusins Mfn1 and Mfn2 are rapid degradation targets of Parkin, we find that degradation of additional targets is essential for mitophagy. These results indicate that remodeling of the mitochondrial outer membrane proteome is important for mitophagy, and reveal a causal link between the UPS and autophagy, the major pathways for degradation of intracellular substrates