375 research outputs found
Unified Field Theory From Enlarged Transformation Group. The Covariant Derivative for Conservative Coordinate Transformations and Local Frame Transformations
Pandres has developed a theory in which the geometrical structure of a real
four-dimensional space-time is expressed by a real orthonormal tetrad, and the
group of diffeomorphisms is replaced by a larger group called the conservation
group. This paper extends the geometrical foundation for Pandres' theory by
developing an appropriate covariant derivative which is covariant under all
local Lorentz (frame) transformations, including complex Lorentz
transformations, as well as conservative transformations. After defining this
extended covariant derivative, an appropriate Lagrangian and its resulting
field equations are derived. As in Pandres' theory, these field equations
result in a stress-energy tensor that has terms which may automatically
represent the electroweak field. Finally, the theory is extended to include
2-spinors and 4-spinors.Comment: Aug 25 replacement has corrected margin width
Palatini Variational Principle for an Extended Einstein-Hilbert Action
We consider a Palatini variation on a generalized Einstein-Hilbert action. We
find that the Hilbert constraint, that the connection equals the Christoffel
symbol, arises only as a special case of this general action, while for
particular values of the coefficients of this generalized action, the
connection is completely unconstrained. We discuss the relationship between
this situation and that usually encountered in the Palatini formulation.Comment: 14 pages, LaTe
The geometrical form for the string space-time action
In the present article, we derive the space-time action of the bosonic string
in terms of geometrical quantities. First, we study the space-time geometry
felt by probe bosonic string moving in antisymmetric and dilaton background
fields. We show that the presence of the antisymmetric field leads to the
space-time torsion, and the presence of the dilaton field leads to the
space-time nonmetricity. Using these results we obtain the integration measure
for space-time with stringy nonmetricity, requiring its preservation under
parallel transport. We derive the Lagrangian depending on stringy curvature,
torsion and nonmetricity.Comment: 13 page
Resonant production of fermions in an axial background
We consider the resonant production of fermions from an oscillating axial
background. The classical evolution of the axial field is given by that of a
massive pseudovector field, as suggested by the renormalizability of the
theory. We look upon both the massive and the massless fermion production from
a perturbative point of view. We obtain the corresponding spectrum and angular
distributions for the different spins or helicities in the particular case of a
spatial-like axial field. We also extend our study to the non-perturbative
regime in the massless case and compare the results with the perturbative ones.Comment: 16 pages, LaTeX, 12 figures; new comments and references added,
version to appear in Phys. Rev.
Alternate SlyA and H-NS nucleoprotein complexes control hlyE expression in Escherichia coli K-12
Haemolysin E is a cytolytic pore-forming toxin found in several Escherichia coli and Salmonella enterica strains. Expression of hlyE is repressed by the global regulator H-NS (histone-like nucleoid structuring protein), but can be activated by the regulator SlyA. Expression of a chromosomal hlyE–lacZ fusion in an E. coli slyA mutant was reduced to 60% of the wild-type level confirming a positive role for SlyA. DNase I footprint analysis revealed the presence of two separate SlyA binding sites, one located upstream, the other downstream of the hlyE transcriptional start site. These sites overlap AT-rich H-NS binding sites. Footprint and gel shift data showed that whereas H-NS prevented binding of RNA polymerase (RNAP) at the hlyE promoter (PhlyE), SlyA allowed binding of RNAP, but inhibited binding of H-NS. Accordingly, in vitro transcription analyses showed that addition of SlyA protein relieved H-NS-mediated repression of hlyE. Based on these observations a model for SlyA/H-NS regulation of hlyE expression is proposed in which the relative concentrations of SlyA and H-NS govern the nature of the nucleoprotein complexes formed at PhlyE. When H-NS is dominant RNAP binding is inhibited and hlyE expression is silenced; when SlyA is dominant H-NS binding is inhibited allowing RNAP access to the promoter facilitating hlyE transcription
Three dimensional thermal-solute phase field simulation of binary alloy solidification
We employ adaptive mesh refinement, implicit time stepping, a nonlinear multigrid solver and parallel computation to solve a multi-scale, time dependent, three dimensional, nonlinear set of coupled partial differential equations for three scalar field variables. The mathematical model represents the non-isothermal solidification of a metal alloy into a melt substantially cooled below its freezing point at the microscale. Underlying physical molecular forces are captured at this scale by a specification of the energy field. The time rate of change of the temperature, alloy concentration and an order parameter to govern the state of the material (liquid or solid) are controlled by the diffusion parameters and variational derivatives of the energy functional. The physical problem is important to material scientists for the development of solid metal alloys and, hitherto, this fully coupled thermal problem has not been simulated in three dimensions, due to its computationally demanding nature. By bringing together state of the art numerical techniques this problem is now shown here to be tractable at appropriate resolution with relatively moderate computational resources
Governing infrastructure networks for a low carbon economy:co-evolution of technologies and institutions in UK electricity distribution networks
Melting as a String-Mediated Phase Transition
We present a theory of the melting of elemental solids as a
dislocation-mediated phase transition. We model dislocations near melt as
non-interacting closed strings on a lattice. In this framework we derive simple
expressions for the melting temperature and latent heat of fusion that depend
on the dislocation density at melt. We use experimental data for more than half
the elements in the Periodic Table to determine the dislocation density from
both relations. Melting temperatures yield a dislocation density of (0.61\pm
0.20) b^{-2}, in good agreement with the density obtained from latent heats,
(0.66\pm 0.11) b^{-2}, where b is the length of the smallest
perfect-dislocation Burgers vector. Melting corresponds to the situation where,
on average, half of the atoms are within a dislocation core.Comment: 18 pages, LaTeX, 3 eps figures, to appear in Phys. Rev.
Heart re-transplantation in Eurotransplant
Internationally 3% of the donor hearts are distributed to re-transplant patients. In Eurotransplant, only patients with a primary graft dysfunction (PGD) within 1 week after heart transplantation (HTX) are indicated for high urgency listing. The aim of this study is to provide evidence for the discussion on whether these patients should still be allocated with priority. All consecutive HTX performed in the period 1981-2015 were included. Multivariate Cox' model was built including: donor and recipient age and gender, ischaemia time, recipient diagnose, urgency status and era. The study population included 18 490 HTX, of these 463 (2.6%) were repeat transplants. The major indications for re-HTX were cardiac allograft vasculopathy (CAV) (50%), PGD (26%) and acute rejection (21%). In a multivariate model, compared with first HTX hazards ratio and 95% confidence interval for repeat HTX were 2.27 (1.83-2.82) for PGD, 2.24 (1.76-2.85) for acute rejection and 1.22 (1.00-1.48) for CAV (P < 0.0001). Outcome after cardiac re-HTX strongly depends on the indication for re-HTX with acceptable outcomes for CAV. In contrast, just 47.5% of all hearts transplanted in patients who were re-transplanted for PGD still functioned at 1-month post-transplant. Alternative options like VA-ECMO should be first offered before opting for acute re-transplantation
Systematic Reviews of Animal Experiments Demonstrate Poor Human Clinical and Toxicological Utility
The assumption that animal models are reasonably predictive of human outcomes provides the basis for their widespread use in toxicity testing and in biomedical research aimed at developing cures for human diseases. To investigate the validity of this assumption, the comprehensive Scopus biomedical bibliographic databases were searched for published systematic reviews of the human clinical or toxicological utility of animal experiments. In 20 reviews in which clinical utility was examined, the authors concluded that animal models were either significantly useful in contributing to the development of clinical interventions, or were substantially consistent with clinical outcomes, in only two cases, one of which was contentious. These included reviews of the clinical utility of experiments expected by ethics committees to lead to medical advances, of highly-cited experiments published in major journals, and of chimpanzee experiments — those involving the species considered most likely to be predictive of human outcomes. Seven additional reviews failed to clearly demonstrate utility in predicting human toxicological outcomes, such as carcinogenicity and teratogenicity. Consequently, animal data may not generally be assumed to be substantially useful for these purposes. Possible causes include interspecies differences, the distortion of outcomes arising from experimental environments and protocols, and the poor methodological quality of many animal experiments, which was evident in at least 11 reviews. No reviews existed in which the majority of animal experiments were of good methodological quality. Whilst the effects of some of these problems might be minimised with concerted effort (given their widespread prevalence), the limitations resulting from interspecies differences are likely to be technically and theoretically impossible to overcome. Non-animal models are generally required to pass formal scientific validation prior to their regulatory acceptance. In contrast, animal models are simply assumed to be predictive of human outcomes. These results demonstrate the invalidity of such assumptions. The consistent application of formal validation studies to all test models is clearly warranted, regardless of their animal, non-animal, historical, contemporary or possible future status. Likely benefits would include, the greater selection of models truly predictive of human outcomes, increased safety of people exposed to chemicals that have passed toxicity tests, increased efficiency during the development of human pharmaceuticals and other therapeutic interventions, and decreased wastage of animal, personnel and financial resources. The poor human clinical and toxicological utility of most animal models for which data exists, in conjunction with their generally substantial animal welfare and economic costs, justify a ban on animal models lacking scientific data clearly establishing their human predictivity or utility
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