2,247 research outputs found
D-Branes on K3-Fibrations
B-type D-branes are constructed on two different K3-fibrations over IP_1
using boundary conformal field theory at the rational Gepner points of these
models. The microscopic CFT charges are compared with the Ramond charges of
D-branes wrapped on holomorphic cycles of the corresponding Calabi-Yau
manifold. We study in particular D4-branes and bundles localized on the K3
fibers, and find from CFT that each irreducible component of a bundle on K3
gains one modulus upon fibration over IP_1. This is in agreement with
expectations and so provides a further test of the boundary CFT.Comment: 16p, harvmac, tables.tex; typos corrected, refs added, discussion
about moduli spaces improve
Fermi surface instabilities at finite Temperature
We present a new method to detect Fermi surface instabilities for interacting
systems at finite temperature. We first apply it to a list of cases studied
previously, recovering already known results in a very economic way, and
obtaining most of the information on the phase diagram analytically. As an
example, in the continuum limit we obtain the critical temperature as an
implicit function of the magnetic field and the chemical potential
. By applying the method to a model proposed to describe reentrant
behavior in , we reproduce the phase diagram obtained
experimentally and show the presence of a non-Fermi Liquid region at
temperatures above the nematic phase.Comment: 10 pages, 10 figure
Association of FCGR3A and FCGR3B haplotypes with rheumatoid arthritis and primary Sjögren's syndrome [POSTER PRESENTATION]
Background
Rheumatoid arthritis (RA) is an autoimmune disease that is thought to arise from a complex interaction between multiple genetic factors and environmental triggers. We have previously demonstrated an association between a Fc gamma receptor (FcγR) haplotype and RA in a cross-sectional cohort of RA patients. We have sought to confirm this association in an inception cohort of RA patients and matched controls. We also extended our study to investigate a second autoanti-body associated rheumatic disease, primary Sjögren's syndrome (PSS).
Methods
The FCGR3A-158F/V and FCGR3B-NA1/NA2 functional polymorphisms were examined for association in an inception cohort of RA patients (n = 448), and a well-characterised PSS cohort (n = 83) from the United Kingdom. Pairwise disequilibrium coefficients (D') were calculated in 267 Blood Service healthy controls. The EHPlus program was used to estimate haplotype frequencies for patients and controls and to determine whether significant linkage disequilibrium was present. A likelihood ratio test is performed to test for differences between the haplotype frequencies in cases and controls. A permutation procedure implemented in this program enabled 1000 permutations to be performed on all haplotype associations to assess significance.
Results
There was significant linkage disequilibrium between FCGR3A and FCGR3B (D' = -0.445, P = 0.001). There was no significant difference in the FCGR3A or FCGR3B allele or genotype frequencies in the RA or PSS patients compared with controls. However, there was a significant difference in the FCGR3A-FCGR3B haplotype distributions with increased homozygosity for the FCGR3A-FCGR3B 158V-NA2 haplotype in both our inception RA cohort (odds ratio = 2.15, 95% confidence interval = 1.1–4.2 P = 0.027) and PSS (odds ratio = 2.83, 95% confidence interval = 1.0–8.2, P = 0.047) compared with controls. The reference group for these analyses comprised individuals who did not possess a copy of the FCGR3A-FCGR3B 158V-NA2 haplotype.
Conclusions
We have confirmed our original findings of association between the FCGR3A-FCGR3B 158V-NA2 haplotype and RA in a new inception cohort of RA patients. This suggests that there may be an RA-susceptibility gene at this locus. The significant increased frequency of an identical haplotype in PSS suggests the FcγR genetic locus may contribute to the pathogenesis of diverse autoantibody-mediated rheumatic diseases
Parity Violation in Proton-Proton Scattering
Measurements of parity-violating longitudinal analyzing powers (normalized
asymmetries) in polarized proton-proton scattering provide a unique window on
the interplay between the weak and strong interactions between and within
hadrons. Several new proton-proton parity violation experiments are presently
either being performed or are being prepared for execution in the near future:
at TRIUMF at 221 MeV and 450 MeV and at COSY (Kernforschungsanlage Juelich) at
230 MeV and near 1.3 GeV. These experiments are intended to provide stringent
constraints on the set of six effective weak meson-nucleon coupling constants,
which characterize the weak interaction between hadrons in the energy domain
where meson exchange models provide an appropriate description. The 221 MeV is
unique in that it selects a single transition amplitude (3P2-1D2) and
consequently constrains the weak meson-nucleon coupling constant h_rho{pp}. The
TRIUMF 221 MeV proton-proton parity violation experiment is described in some
detail. A preliminary result for the longitudinal analyzing power is Az = (1.1
+/-0.4 +/-0.4) x 10^-7. Further proton-proton parity violation experiments are
commented on. The anomaly at 6 GeV/c requires that a new multi-GeV
proton-proton parity violation experiment be performed.Comment: 13 Pages LaTeX, 5 PostScript figures, uses espcrc1.sty. Invited talk
at QULEN97, International Conference on Quark Lepton Nuclear Physics --
Nonperturbative QCD Hadron Physics & Electroweak Nuclear Processes --, Osaka,
Japan May 20--23, 199
Quaternionic and Octonionic Spinors. A Classification
Quaternionic and octonionic realizations of Clifford algebras and spinors are
classified and explicitly constructed in terms of recursive formulas. The most
general free dynamics in arbitrary signature space-times for both quaternionic
and octonionic spinors is presented. In the octonionic case we further provide
a systematic list of results and tables expressing, e.g., the relations of the
octonionic Clifford algebras with the cosets over the Lorentz algebras,
the identities satisfied by the higher-rank antisymmetric octonionic tensors
and so on. Applications of these results range from the classification of
octonionic generalized supersymmetries, the construction of octonionic
superstrings, as well as the investigations concerning the recently discovered
octonionic -superalgebra and its superconformal extension.Comment: 24 pages, LaTe
The Generalized Green-Schwarz Mechanism for Type IIB Orientifolds with D3- and D7-Branes
In this paper, we work out in detail the tadpole cancellation conditions as
well as the generalized Green-Schwarz mechanism for type IIB orientifold
compactifications with D3- and D7-branes. We find that not only the well-known
D3- and D7-tadpole conditions have to be satisfied, but in general also the
vanishing of the induced D5-brane charges leads to a non-trivial constraint. In
fact, for the case the latter condition is important for
the cancellation of chiral anomalies. We also extend our analysis by including
D9- as well as D5-branes and determine the rules for computing the chiral
spectrum of the combined system.Comment: 33+7 pages; 2 figures; v2: references added; v3: published versio
Combinatorial Markov chains on linear extensions
We consider generalizations of Schuetzenberger's promotion operator on the
set L of linear extensions of a finite poset of size n. This gives rise to a
strongly connected graph on L. By assigning weights to the edges of the graph
in two different ways, we study two Markov chains, both of which are
irreducible. The stationary state of one gives rise to the uniform
distribution, whereas the weights of the stationary state of the other has a
nice product formula. This generalizes results by Hendricks on the Tsetlin
library, which corresponds to the case when the poset is the anti-chain and
hence L=S_n is the full symmetric group. We also provide explicit eigenvalues
of the transition matrix in general when the poset is a rooted forest. This is
shown by proving that the associated monoid is R-trivial and then using
Steinberg's extension of Brown's theory for Markov chains on left regular bands
to R-trivial monoids.Comment: 35 pages, more examples of promotion, rephrased the main theorems in
terms of discrete time Markov chain
Anomalies, Fayet-Iliopoulos terms and the consistency of orbifold field theories
We study the consistency of orbifold field theories and clarify to what
extent the condition of having an anomaly-free spectrum of zero-modes is
sufficient to guarantee it. Preservation of gauge invariance at the quantum
level is possible, although at the price, in general, of introducing operators
that break the 5d local parity. These operators are, however, perfectly
consistent with the orbifold projection. We also clarify the relation between
localized Fayet-Iliopoulos (FI) terms and anomalies. These terms can be
consistently added, breaking neither local supersymmetry nor the gauge
symmetry. In the framework of supergravity the localized FI term arises as the
boundary completion of a bulk interaction term: given the bulk Lagrangian the
FI is fixed by gauge invariance.Comment: 31 pages, 1 figure. v2: some typos corrected, references adde
A Monitor of Beam Polarization Profiles for the TRIUMF Parity Experiment
TRIUMF experiment E497 is a study of parity violation in pp scattering at an
energy where the leading term in the analyzing power is expected to vanish,
thus measuring a unique combination of weak-interaction flavour conserving
terms. It is desired to reach a level of sensitivity of 2x10^-8 in both
statistical and systematic errors. The leading systematic errors depend on
transverse polarization components and, at least, the first moment of
transverse polarization. A novel polarimeter that measures profiles of both
transverse components of polarization as a function of position is described.Comment: 19 pages LaTeX, 10 PostScript figures. To appear in Nuclear
Instruments and Methods in Physics Research, Section
Parity Violation in Proton-Proton Scattering at 221 MeV
TRIUMF experiment 497 has measured the parity violating longitudinal
analyzing power, A_z, in pp elastic scattering at 221.3 MeV incident proton
energy. This paper includes details of the corrections, some of magnitude
comparable to A_z itself, required to arrive at the final result. The largest
correction was for the effects of first moments of transverse polarization. The
addition of the result, A_z=(0.84 \pm 0.29 (stat.) \pm 0.17 (syst.)) \times
10^{-7}, to the pp parity violation experimental data base greatly improves the
experimental constraints on the weak meson-nucleon coupling constants
h^{pp}_\rho and h^{pp}_\omega, and has implications for the interpretation of
electron parity violation experiments.Comment: 17 pages RevTeX, 14 PostScript figures. Revised version with
additions suggested by Phys. Rev.
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