In Situ Electrochemical Investigations of Inherently Chiral 2,2′-Biindole Architectures with Oligothiophene Terminals

AbstractThe synthesis and characterization of three new inherently chiral N,N′‐dipropyl‐3,3′‐diheteroaryl‐2,2′‐biindole monomers, nicknamed Ind2T4, Ind2T6 and Ind2Ph2T4, which differ in the number of thiophenes as terminals, are reported. In addition to a full monomer characterization, stable electroactive oligomeric films were obtained by electro‐oxidation upon cycling to potentials which activate the thiophene terminals. Cyclic voltammetry, UV‐Vis‐NIR spectroelectrochemistry and in situ conductance measurements show that oligomeric films of Ind2T6 present the best stability and electrochromic switching performance. Enantioselective tests with a chiral ferrocene amine clearly show the potential as chiral selectors for analytical and sensing purposes

Volatile constituents of Festuca nigrescens, Phleum alpinum and Poa alpina from N. W. Italian Alpine pastures.

The composition of the volatile fractions of three important grasses from subalpine N.W. Italian pastures, namely Festuca nigrescens Lam. non Gaudin (chewing fescue), Phleum alpinum L. (alpine timothy) and Poa alpina L. (alpine bluegrass) was investigated. The fresh aerial parts were collected at the flowering stage during the summer season. The volatile oils obtained from green tissues by steam distillation in a Clevenger-type apparatus, were analyzed by GC/FID and GC/MS. The oil yield was 0.04 ± 0.01% weight/fresh weight bases for each of the investigated species. Several classes of compounds were found in the volatile fractions, including aldehydes, alcohols, acids, hydrocarbons, esters, ketones, terpenes, and phenolics. Qualitative and quantitative differences were observed

Cover Feature: In Situ Electrochemical Investigations of Inherently Chiral 2,2′-Biindole Architectures with Oligothiophene Terminals (ChemElectroChem 17/2021)

n/

Anxiolysis in the Surgical Management of a Compound Odontoma in a Pediatric Patient

Among odontogenic tumors, odontoma is the most frequent. The common treatment contemplates a conservative approach. While this procedure is generally accepted and tolerated, some difficulties may be encountered in the case of pediatric patients. Indeed, negative feelings of tension, apprehension, nervousness, and fear are likely to occur. The present report is aimed at discussing the management of a compound odontoma in a pediatric patient under anxiolysis with diazepam on an outpatient basis. The surgery was carried out without complications, and the discharge was completed safely. Oral premedication with diazepam should be considered to avoid more invasive sedation procedures in anxious pediatric patients

Spin-dependent electrochemistry: Enantio-selectivity driven by chiral-induced spin selectivity effect

Spin-Dependent Electrochemistry (SDE) is a new paradigm in electrochemistry where the electrochemical response of a chiral electrode|solution interface is studied as a function of spin-polarized current. In this work, the SDE concept is further developed exploring the use of the “chiral imprinting” concept, which is implemented in two different, complementary, ways i) a chiral compound in bulk solution to obtain chiral-induced spin selectivity effect at the ferromagnetic (FM) electrode surface ii) conversely, a chiral-ferromagnetic (CFM) hybrid working electrode is produced: nickel is electrochemically co-deposited with a chiral compound, L-ta or D-(−)-tartaric acid, which is added to the electrodeposition bath; this allows to obtain a chiral co-deposited nickel-tartaric acid (Ni-LTA or Ni-DTA) working electrode. As a further innovation, the ferromagnetic working electrode is prepared by direct Ni electrodeposition on the north, or south, pole of a permanent magnet. The electrochemical response of these two chiral imprinted systems is studied by comparing cyclic voltammetry (CV) curves. The latter are recorded in the potential range relevant to the Ni(III)/Ni(II) electrochemical equilibrium, and also in the presence of glucose in bulk solution. An impressive variation in peak potentials is found when comparing CVs recorded on the north, versus south, pole of the magnet (in particular, when the co-deposited CFM working electrode is used). These results are properly rationalized within the Chiral-Induced Spin Selectivity (CISS) effect

Non aver paura di dire... Odio

n

Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)

Introduction: An ongoing national multicenter survey [Italian Oncologic Pain multiSetting Multicentric Survey (IOPS-MS)] is evaluating the characteristics of breakthrough cancer pain (BTP) in different clinical settings. Preliminary data from the first 1500 cancer patients with BTP enrolled in this study are presented here. Methods: Thirty-two clinical centers are involved in the survey. A diagnosis of BTP was performed by a standard algorithm. Epidemiological data, Karnofsky index, stage of disease, presence and sites of metastases, ongoing oncologic treatment, and characteristics of background pain and BTP and their treatments were recorded. Background pain and BTP intensity were measured. Patients were also questioned about BTP predictability, BTP onset (≤10 or >10 min), BTP duration, background and BTP medications and their doses, time to meaningful pain relief after BTP medication, and satisfaction with BTP medication. The occurrence of adverse reactions was also assessed, as well as mucosal toxicity. Results: Background pain was well controlled with opioid treatment (numerical rating scale 3.0 ± 1.1). Patients reported 2.5 ± 1.6 BTP episodes/day with a mean intensity of 7.5 ± 1.4 and duration of 43 ± 40 min; 977 patients (65.1%) reported non-predictable BTP, and 1076 patients (71.7%) reported a rapid onset of BTP (≤10 min). Higher patient satisfaction was reported by patients treated with fast onset opioids. Conclusions: These preliminary data underline that the standard algorithm used is a valid tool for a proper diagnosis of BTP in cancer patients. Moreover, rapid relief of pain is crucial for patients’ satisfaction. The final IOPS-MS data are necessary to understand relationships between BTP characteristics and other clinical variables in oncologic patients. Funding: Molteni Farmaceutici, Italy