Determinação de olanzapina em formulações farmacêuticas por espectrofotometria: desenvolvimento e validação

Spectrophotometric methods of zero order, first and second derived order had been developed for olanzapine determination in tablets using ethanol and isopropanol as solvent. The two solvents revealed to be adequate. For the three methods the calibration curve coefficient of correlation had been greater than 0.9998 with limit of detection varying from 0.068 to 0.190 mg L-1, in ethanol, and 0.026 to 0.205 mg L-1, in isopropanol. The inter-day precision was inferior to 1.1 and 1.9 mg L-1 for ethanol and isopropanol, respectively. The average recoveries varied from 98 to 101%, in ethanol and 99 to 103% in isopropanol

Development and validation of a method for the determination of folic acid in different pharmaceutical formulations using derivative spectrophotometry

Folic acid is a B complex water-soluble vitamin that is essential to humans, and its deficiency can cause problems including congenital malformations in the fetus as well as heart disease. Most countries affected by diseases associated with a lack of folic acid now supplement foods with the vitamin. There is therefore a need for the development of new analytical procedures able to determine folic acid present in different matrices. This work describes the development of zero order and first order derivative spectrophotometric methods for the determination of folic acid in different pharmaceutical formulations, using 0.1 mol L-1 NaOH as solvent. The methods are shown to be simple, selective, and robust. Good linearity was achieved, with correction coefficients ≥0.9996 and limits of detection and quantification ranging from 0.64 to 0.75 and from 1.80 to 2.85 mg L-1, respectively. Recoveries of 98-104% were obtained in accuracy tests, and precision (as RSD) was between 0.2 and 4.8%. The methods can be used in routine analyses for quality control purposes, offering an alternative to the procedures already reported in the literature

Propriedades fisico-quimicas de cabelos : avaliação de interações com corante e surfactantes

Orientadora : Ines JoekesDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de QuimicaMestrad

Estudo sobre a aplicação do paraformaldeido como indicador termometrico na determinação da acidez de petroleo e derivados

Orientadores: Graciliano de Oliveira Neto, Oswaldo E. S. GodinhoTese (doutorado) - Universidade Estadual de Campinas, Instituto de QuimicaDoutorad

Analysis and assessment of heavy metals in urban surface soils of Teresina, Piauí State, Brazil: a study based on multivariate analysis

The concentration of Cu, Pb, Zn, Cr, Ni and Mn in the surface soil samples from Teresina city were measured by flame atomic absorption spectrometry (FAAS). A total of 28 composite soil samples were collected at depths 0-10 cm, including residential districts, urban parks, green areas, vegetable-garden, heavy- and low-traffic density areas. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were used to analyze the data and identify possible sources of these heavy metals. The results of the multivariate analysis showed that Cu, Pb, Zn and Cr were associated mainly to anthropogenic activities, such as, fertilizer and vehicle emission. While Ni and Mn were controlled by original materials and therefore interpreted as natural sources.The concentration of Cu, Pb, Zn, Cr, Ni and Mn in the surface soil samples from Teresina city were measured by flame atomic absorption spectrometry (FAAS). A total of 28 composite soil samples were collected at depths 0-10 cm, including residential districts, urban parks, green areas, vegetable-garden, heavy- and low-traffic density areas. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were used to analyze the data and identify possible sources of these heavy metals. The results of the multivariate analysis showed that Cu, Pb, Zn and Cr were associated mainly to anthropogenic activities, such as, fertilizer and vehicle emission. While Ni and Mn were controlled by original materials and therefore interpreted as natural sources. Análise e avaliação dos metais pesados em solos superficiais urbanos de Teresina,Estado do Piauí, Brasil: um estudo baseado em análise multivariadaResumoA concentração de Cu, Pb, Zn, Cr, Ni and Mn nas amostras de solo superficial da cidade deTeresina foram medidas por espectroscopia de absorção atômica em chama (FAAS). Um total de28 amostras compostas de solo foram coletadas numa profundidade de 0–10 cm, incluindo distritosresidenciais, parques urbanos, áreas verdes, hortas, áreas de densidade de tráfico baixo e alto.Análise por componentes principais (PCA) e análise por agrupamento hierárquico (HCA) foramusadas para analisar os dados e identificar as possíveis fontes desses metais pesados. Os resultadosda análise multivariada mostraram que Cu, Pb, Zn e Cr foram associados, principalmente, àsatividades antropogênicas, tais como, fertilizantes e emissões veiculares. Enquanto Ni e Mn foramcontrolados por material parente, portanto interpretado como fonte natural