55 research outputs found
2022 Upgrade and Improved Low Frequency Camera Sensitivity for CMB Observation at the South Pole
Constraining the Galactic foregrounds with multi-frequency Cosmic Microwave
Background (CMB) observations is an essential step towards ultimately reaching
the sensitivity to measure primordial gravitational waves (PGWs), the sign of
inflation after the Big-Bang that would be imprinted on the CMB. The BICEP
Array telescope is a set of multi-frequency cameras designed to constrain the
energy scale of inflation through CMB B-mode searches while also controlling
the polarized galactic foregrounds. The lowest frequency BICEP Array receiver
(BA1) has been observing from the South Pole since 2020 and provides 30 GHz and
40 GHz data to characterize the Galactic synchrotron in our CMB maps. In this
paper, we present the design of the BA1 detectors and the full optical
characterization of the camera including the on-sky performance at the South
Pole. The paper also introduces the design challenges during the first
observing season including the effect of out-of-band photons on detectors
performance. It also describes the tests done to diagnose that effect and the
new upgrade to minimize these photons, as well as installing more dichroic
detectors during the 2022 deployment season to improve the BA1 sensitivity. We
finally report background noise measurements of the detectors with the goal of
having photon noise dominated detectors in both optical channels. BA1 achieves
an improvement in mapping speed compared to the previous deployment season.Comment: Proceedings of SPIE Astronomical Telescopes + Instrumentation 2022
(AS22
Soil water content temporal-spatial variability of the surface layer of a Loess Plateau hillside in China
Relationships between expanding pinyon–juniper cover and topography in the central Great Basin, Nevada
α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors.
OBJECTIVE: Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) plays a role in glucose homeostasis and tested the hypothesis that the pituitary is able to sense a physiological increase in circulating glucose and responds by secreting α-MSH. METHODS: We established glucose-stimulated α-MSH secretion using humans, non-human primates, and mouse models. Continuous α-MSH infusions were performed during glucose tolerance tests and hyperinsulinemic-euglycemic clamps to evaluate the systemic effect of α-MSH in glucose regulation. Complementary ex vivo and in vitro techniques were employed to delineate the direct action of α-MSH via the melanocortin 5 receptor (MC5R)-PKA axis in skeletal muscles. Combined treatment of non-selective/selective phosphodiesterase inhibitor and α-MSH was adopted to restore glucose tolerance in obese mice. RESULTS: Here we demonstrate that pituitary secretion of α-MSH is increased by glucose. Peripheral α-MSH increases temperature in skeletal muscles, acts directly on soleus and gastrocnemius muscles to significantly increase glucose uptake, and enhances whole-body glucose clearance via the activation of muscle MC5R and protein kinase A. These actions are absent in obese mice, accompanied by a blunting of α-MSH-induced cAMP levels in skeletal muscles of obese mice. Both selective and non-selective phosphodiesterase inhibition restores α-MSH induced skeletal muscle glucose uptake and improves glucose disposal in obese mice. CONCLUSION: These data describe a novel endocrine circuit that modulates glucose homeostasis by pituitary α-MSH, which increases muscle glucose uptake and thermogenesis through the activation of a MC5R-PKA-pathway, which is disrupted in obesity
Overwintering of Gopher Tortoises (Gopherus polyphemus) Translocated to the Northern Limit of Their Geographic Range: Temperatures, Timing, and Survival
The Effects of Sex and Season on Patterns of Thermoregulation in Blanding's Turtles (Emydoidea blandingii) in Ontario, Canada
Acceleration and Propagation of Solar Energetic Particles
Solar Energetic Particles (SEPs) are an important component of Space Weather, including radiation hazard to humans and electronic equipment, and the ionisation of the Earth’s atmosphere. We review the key observations of SEPs, our current understanding of their acceleration and transport, and discuss how this knowledge is incorporated within Space Weather forecasting tools. Mechanisms for acceleration during solar flares and at shocks driven by Coronal Mass Ejections (CMEs) are discussed, as well as the timing relationships between signatures of solar eruptive events and the detection of SEPs in interplanetary space. Evidence on how the parameters of SEP events are related to those of the parent solar activity is reviewed and transport effects influencing SEP propagation to near-Earth locations are examined. Finally, the approaches to forecasting Space Weather SEP effects are discussed. We conclude that both flare and CME shock acceleration contribute to Space Weather relevant SEP populations and need to be considered within forecasting tools
Early human dispersals within the Americas.
Studies of the peopling of the Americas have focused on the timing and number of initial migrations. Less attention has been paid to the subsequent spread of people within the Americas. We sequenced 15 ancient human genomes spanning from Alaska to Patagonia; six are ≥10,000 years old (up to ~18× coverage). All are most closely related to Native Americans, including those from an Ancient Beringian individual and two morphologically distinct "Paleoamericans." We found evidence of rapid dispersal and early diversification that included previously unknown groups as people moved south. This resulted in multiple independent, geographically uneven migrations, including one that provides clues of a Late Pleistocene Australasian genetic signal, as well as a later Mesoamerican-related expansion. These led to complex and dynamic population histories from North to South America
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