7,245 research outputs found
From single steps to mass migration: the problem of scale in the movement ecology of the Serengeti wildebeest
A central question in ecology is how to link processes that occur over
different scales. The daily interactions of individual organisms ultimately
determine community dynamics, population fluctuations and the functioning
of entire ecosystems. Observations of these multiscale ecological
processes are constrained by various technological, biological or logistical
issues, and there are often vast discrepancies between the scale at which
observation is possible and the scale of the question of interest. Animal
movement is characterized by processes that act over multiple spatial and
temporal scales. Second-by-second decisions accumulate to produce
annual movement patterns. Individuals influence, and are influenced by,
collective movement decisions, which then govern the spatial distribution
of populations and the connectivity of meta-populations. While the
field of movement ecology is experiencing unprecedented growth in the
availability of movement data, there remain challenges in integrating
observations with questions of ecological interest. In this article, we present
the major challenges of addressing these issues within the context of the
Serengeti wildebeest migration, a keystone ecological phenomena that
crosses multiple scales of space, time and biological complexity.
This article is part of the theme issue ’Collective movement ecology’
The Chelsea Critical Care Physical Assessment Tool (CPAx): validation of an innovative new tool to measure physical morbidity in the general adult critical care population; an observational proof-of-concept pilot study.
Objective To develop a scoring system to measure physical morbidity in critical care – the Chelsea Critical Care Physical Assessment Tool (CPAx). Method The development process was iterative involving content validity indices (CVI), a focus group and an observational study of 33 patients to test construct validity against the Medical Research Council score for muscle strength, peak cough flow, Australian Therapy Outcome Measures score, Glasgow Coma Scale score, Bloomsbury sedation score, Sequential Organ Failure Assessment score, Short Form 36 (SF-36) score, days of mechanical ventilation and inter-rater reliability. Participants Trauma and general critical care patients from two London teaching hospitals. Results Users of the CPAx felt that it possessed content validity, giving a final CVI of 1.00 (P < 0.05). Construct validation data showed moderate to strong significant correlations between the CPAx score and all secondary measures, apart from the mental component of the SF-36 which demonstrated weak correlation with the CPAx score (r = 0.024, P = 0.720). Reliability testing showed internal consistency of α = 0.798 and inter-rater reliability of κ = 0.988 (95% confidence interval 0.791 to 1.000) between five raters. Conclusion This pilot work supports proof of concept of the CPAx as a measure of physical morbidity in the critical care population, and is a cogent argument for further investigation of the scoring system
An Introduction to the Integrated Community-Engaged Learning and Ethical Reflection Framework (I-CELER)
Cultivating ethical Science, Technology, Engineering, and Mathematics researchers and
practitioners requires movement beyond reducing ethical instruction to the rational exploration of moral quandaries via case studies and into the complexity of the ethical issues that students will encounter within their careers. We designed the Integrated Community-Engaged Learning and Ethical Reflection (I-CELER) framework as a means to promote the ethical becoming of future STEM practitioners. This paper provides a synthesis of and rationale for I-CELER for promoting ethical becoming based on scholarly literature from various social science fields, including social anthropology, moral development, and psychology. This paper proceeds in five parts. First, we introduce the state of the art of engineering ethics instruction; argue for the need of a lens that we describe as ethical becoming; and then detail the Specific Aims of the I-CELER approach. Second, we outline the three interrelated components of the project intervention. Third, we detail our convergent mixed methods research design, including its qualitative and quantitative counterparts. Fourth, we provide a brief description of what a course modified to the I-CELER approach might look like. Finally, we close by detailing the potential impact of this study in light of existing ethics education research within STEM
A complex relationship between immunity and metabolism in Drosophila diet-induced insulin resistance
Dynamic Simulation of Human Thermoregulation and Heat Transfer for Spaceflight Applications
Models of human thermoregulation and heat transfer date from the early 1970s and have been developed for applications ranging from evaluating thermal comfort in spacecraft and aircraft cabin environments to predicting heat stress during EVAs. Most lumped or compartment models represent the body as an assemblage cylindrical and spherical elements which may be subdivided into layers to describe tissue heterogeneity. Many existing models are of limited usefulness in asymmetric thermal environments, such as may be encountered during an EVA. Conventional whole-body clothing models also limit the ability to describe local surface thermal and evaporation effects in sufficient detail. A further limitation is that models based on a standard man model are not readily scalable to represent large or small subjects. This work describes development of a new human thermal model derived from the 41-node man model. Each segment is divided into four concentric, constant thickness cylinders made up of a central core surrounded by muscle, fat, and skin, respectively. These cylinders are connected by the flow of blood from a central blood pool to each part. The central blood pool is updated at each time step, based on a whole-body energy balance. Results show the model simulates core and surface temperature histories, sweat evaporation and metabolic rates which generally are consistent with controlled exposures of human subjects. Scaling rules are developed to enable simulation of small and large subjects (5th percentile and 95th percentile). Future refinements will include a clothing model that addresses local surface insulation and permeation effects and developing control equations to describe thermoregulatory effects such as may occur with prolonged weightlessness or with aging
Are existing soils data meeting the needs of stakeholders in Europe? An analysis of practical use from policy to field
Soils form a major component of the natural system and their functions underpin many key ecosystem goods and services. The fundamental importance of soils in the environment means that many different organisations and stakeholders make extensive use of soils data and information in their everyday working practices. For many reasons, stakeholders are not always aware that they are reliant upon soil data and information to support their activities. Various reviews of stakeholder needs and how soil information could be improved have been carried out in recent years. However, to date, there has been little consideration of user needs from a non-expert perspective. The aim of this study was to explore the use of explicit and hidden soil information in different organisations across Europe and gain a better understanding of improvements needed in soil data and information to assist in practical use by non-expert stakeholders. An on-line questionnaire was used to investigate different uses of soils data and information with 310 responses obtained from 77 organisations across Europe. Results illustrate the widespread use of soil data and information across diverse organisations within Europe, particularly spatial products and soil functional assessments and tools. A wide range of improvements were expressed with a prevalence for finer scale resolution, trends over time, future scenarios, improved accuracy, non-technical supporting information and better capacity to use GIS. An underlying message is that existing legacy soils data need to be supplemented by new up-to-date data to meet stakeholder needs and information gaps
Measurement of ventilation and cardiac related impedance changes with electrical impedance tomography
Introduction Electrical impedance tomography (EIT) has been shown to be able to distinguish both ventilation and perfusion. With adequate filtering the regional distributions of both ventilation and perfusion and their relationships could be analysed. Several methods of separation have been suggested previously, including breath holding, electrocardiograph (ECG) gating and frequency filtering. Many of these methods require interventions inappropriate in a clinical setting. This study therefore aims to extend a previously reported frequency filtering technique to a spontaneously breathing cohort and assess the regional distributions of ventilation and perfusion and their relationship. Methods Ten healthy adults were measured during a breath hold and while spontaneously breathing in supine, prone, left and right lateral positions. EIT data were analysed with and without filtering at the respiratory and heart rate. Profiles of ventilation, perfusion and ventilation/perfusion related impedance change were generated and regions of ventilation and pulmonary perfusion were identified and compared. Results Analysis of the filtration technique demonstrated its ability to separate the ventilation and cardiac related impedance signals without negative impact. It was, therefore, deemed suitable for use in this spontaneously breathing cohort. Regional distributions of ventilation, perfusion and the combined ΔZV/ΔZQ were calculated along the gravity axis and anatomically in each position. Along the gravity axis, gravity dependence was seen only in the lateral positions in ventilation distribution, with the dependent lung being better ventilated regardless of position. This gravity dependence was not seen in perfusion. When looking anatomically, differences were only apparent in the lateral positions. The lateral position ventilation distributions showed a difference in the left lung, with the right lung maintaining a similar distribution in both lateral positions. This is likely caused by more pronounced anatomical changes in the left lung when changing positions. Conclusions The modified filtration technique was demonstrated to be effective in separating the ventilation and perfusion signals in spontaneously breathing subjects. Gravity dependence was seen only in ventilation distribution in the left lung in lateral positions, suggesting gravity based shifts in anatomical structures. Gravity dependence was not seen in any perfusion distributions
Exploring Ethical Development from Standard Instruction in the Contexts of Biomedical Engineering and Earth Science
Ethics continues to be required in the accreditation of engineers. However, ethics is seldom the core focus of departmental instruction. Yet, standard instruction may have myriad impacts on students' ethical development. This study explores students’ ethical formation when ethics is a peripheral or non-intentional aspect of instruction in departmental courses in Biomedical Engineering and Earth Science. The research question that we seek to address is, “In what different ways and to what extent does participation in departmental engineering and science courses cultivate STEM students’ ethical formation?” To address our research question, we disseminated a survey to students before (pre) and after (post) their participation in one of 12 courses offered in Earth Science or Biomedical Engineering during the Fall 2017 or Spring 2018. The survey included four instruments: (1) the Civic-Minded Graduate scale; (2) the Interpersonal Reactivity Index; (3) two relational constructs developed by the authors; and (4) the Defining Issues Test-2. Results suggest that current Earth Science curriculum, overall, positively contributes to students' ethical growth. However, the Biomedical Engineering courses showed no evidence of change. As the Earth Science courses do not explicitly focus on ethics, one potential explanation for this trend is the community-engaged nature of the Earth Science curriculum.
These findings will be beneficial locally to help direct improvements in departmental STEM instruction. In addition, these findings pave the way for future comparative analyses exploring how variations in ethical instruction contribute to students' ethical and professional formation. © 2019 American Society for Engineering Educatio
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