Inclusion of new 5-fluorouracil amphiphilic derivatives in liposome formulation for cancer treatment

Correction for 'Inclusion of new 5-fluorouracil amphiphilic derivatives in liposome formulation for cancer treatment' by M. Petaccia et al., Med. Chem. Commun., 2015, 6, 1639–1642

Does oral health influence school performance and school attendance? A systematic review and meta-analysis.

AIM: To examine the evidence on the influence of oral health status on school performance and school attendance in children and adolescents. DESIGN: A systematic review was performed in accordance with PRISMA included epidemiological studies that assessed concomitantly oral health measures, participants' school performance and/or school attendance. Electronic search was conducted on MEDLINE, SCOPUS, Web of Science, ScienceDirect, and LILACS. Studies published up to May 2018 in any language were eligible. The risk of bias was assessed using the Newcastle-Ottawa Scale. Meta-analysis was used to obtain pooled estimates between oral health measures and school performance and school attendance. RESULTS: Eighteen studies were included. Of them, fifteen studies were used for the meta-analyses. Most studies were assessed as moderate quality. Children with one or more decayed teeth had higher probability of poor school performance (OR = 1.44 95%CI: 1.24-1.64) and poor school attendance (OR = 1.57 95%CI: 1.08-2.05) than caries-free children. Poor parent's perception of child's oral health increased the odds of worse school performance (OR = 1.51 95%CI: 1.10-1.92) and poor school attendance (OR = 1.35 95%CI: 1.14-1.57). CONCLUSIONS: Children and adolescents with dental caries and those reporting worse oral health experience poor school performance and poor school attendance

Erratum: Inclusion of new 5-fluorouracil amphiphilic derivatives in liposome formulation for cancer treatment (Med. Chem. Commun. (2015) 6 (1639-1642))

Correction for 'Inclusion of new 5-fluorouracil amphiphilic derivatives in liposome formulation for cancer treatment' by M. Petaccia et al., Med. Chem. Commun., 2015, 6, 1639-1642

Lacustrine records of Holocene flood pulse dynamics in the Upper Paraguay River watershed (Pantanal wetlands, Brazil)

The Pantanal is the world's largest tropical wetland and a biodiversity hotspot, yet its response to Quaternary environmental change is unclear. To address this problem, sediment cores from shallow lakes connected to the Upper Paraguay River (PR) were analyzed and radiocarbon dated to track changes in sedimentary environments. Stratal relations, detrital particle size, multiple biogeochemical indicators, and sponge spicules suggest fluctuating lake-level lowstand conditions between similar to 11,000 and 5300 cal yr BP, punctuated by sporadic and in some cases erosive flood flows. A hiatus has been recorded from similar to 5300 to 2600 cal yr BP, spurred by confinement of the PR within its channel during an episode of profound regional drought. Sustained PR flooding caused a transgression after similar to 2600 cal yr BP, with lake-level highstand conditions appearing during the Little Ice Age. Holocene PR flood pulse dynamics are best explained by variability in effective precipitation, likely driven by insolation and tropical sea-surface temperature gradients. Our results provide novel support for hypotheses on: (1) stratigraphic discontinuity of floodplain sedimentary archives; (2) late Holocene methane flux from Southern Hemisphere wetlands; and (3) pre-colonial indigenous ceramics traditions in western Brazil. Published by Elsevier B.V. on behalf of University of Washington.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

WATERSHED SPATIAL DISCRETIZATION FOR THE ANALYSIS OF LAND USE CHANGE IN COASTAL REGIONS

In this study, we present a methodology to discretize a non-assessed basin based on terrain analysis using the SRTM digital elevation model (DEM) and a high resolution surface model (DSM) with a drainage network semi-automatic extraction process. The Juqueriquerê River Basin was used for the case study, which has the most representative non-urbanized plains of the northern coastline of São Paulo State, Brazil. The low-lying region is featured by elevations close to the sea level, mild slopes, and shallow water tables. It is also influenced by tidal variation and orographic rains. Therefore, frequent flooding occurs, even in vegetated areas. Two conflicting land use scenarios, proposed by the City Master Plan (CMP) of Caraguatatuba and the Ecological-Economical Zoning (EEZ), were compared to analyze the flood vulnerability increase and geotechnical risk caused by the urbanization process. The drainage extraction techniques showed better results on high resolution DSM for low-lying regions than the SRTM DEM and determined with accuracy the locations of flood potentiality in the plains. The watershed spatial discretization allowed us to show the effects of the two different land use approaches, considering the flood vulnerability and geotechnical risk of each sub-basin