Dynamics of the solar tachocline I: an incompressible study

Gough & McIntyre have suggested that the dynamics of the solar tachocline are dominated by the advection-diffusion balance between the differential rotation, a large-scale primordial field and baroclinicly driven meridional motions. This paper presents the first part of a study of the tachocline, in which a model of the rotation profile below the convection zone is constructed along the lines suggested by Gough & McIntyre and solved numerically. In this first part, a reduced model of the tachocline is derived in which the effects of compressibility and energy transport on the system are neglected; the meridional motions are driven instead by Ekman-Hartmann pumping. It is shown that there exists only a narrow range of magnetic field strengths for which the system can achieve a nearly uniform rotation. The results are discussed with respect to observations and to the limitations of this initial approach. A following paper combines the effects of realistic baroclinic driving and stratification with a model that follows closely the lines of work of Gough & McIntyre.Comment: 18 pages, 15 figures, accepted by MNRA

A Multiple Case Study Analysis of Digital Preservation Techniques across Government, Private, and Public Service Organizations

The process of record keeping has evolved through time. As our technology advances, so does our ability to manage information. We have progressed from paper-based records to new digital techniques and formats to store records. However, digital storage is not the Holy Grail answer to preservation and storage problems. Digital storage is confounded by multiple problems, also. Some of these problems are, but not limited to, lack of standardization and legal guidance, proprietary formats, and the fragility of the digital medium. This research examines several organizations that are deeply involved in digital preservation and tries to identify common practices and problems across the industry

The magnetic field generated by an electron bound in angular-momentum eigenstates

The magnetic field generated by an electron bound in a spherically symmetric potential is calculated for eigenstates of the orbital and total angular momentum. General expressions are presented for the current density in such states and the magnetic field is calculated through the vector potential, which is obtained from the current density by direct integration. The method is applied to the hydrogen atom, for which we reproduce and extend known results.Comment: This article is a long version of our article which will appear in Eur. J.phys.20. It contains 22 pages 3 figure

Review of meteoroid-bumper interaction studies at McGill University

Experimental investigation of meteoroid-bumper impact, debris cloud expansion, and second surface pressure loadin

Thrombotic variables and risk of idiopathic venous thromboembolism in women aged 45-64 years - Relationships to hormone replacement therapy

Hormone replacement therapy (HRT) has been shown to increase the relative risk of idiopathic venous thromboembolism (VTE) about threefold in several observational studies and one randomised controlled trial. Whether or not this relative risk is higher in women with underlying thrombophilia phenotypes, such as activated protein C (APC) resistance, is unknown. We therefore restudied the participants in a case-control study of the relationship between the use of HRT and the occurrence of idiopathic VTE in women aged 45-64 years. After protocol exclusions, 66 of the cases in the original study and 163 of the controls were studied. Twenty haematological variables relevant to risk of VTE were analysed, including thrombotic states defined from the literature. The relative risk of VTE showed significant associations with APC resistance (OR 4.06; 95% CI 1.62, 10.21); low antithrombin (3.33; 1.15, 9.65) or protein C (2.93; 1.06, 8.14); and high coagulation factor IX (2.34: 1.26, 1.35), or fibrin D-dimer (3.84; 1.99, 7.32). HRT use increased the risk of VTE in women without any of these thrombotic static; (OR 4.09; 95% CI 1.26, 13.30). A similar effect of HRT use on the relative risk of VTE was also found in women with prothrombotic states. Thus for example, the combination of HRT use and APC resistance increased the risk of VTE about 13-fold compared with women of similar age without either APC resistance or HRT use (OR 13.27; 95%, CI 4.30, 40.97). We conclude that the combination of HRT use and thrombophilias (especially if multiple) increases the relative risk of VTE substantially; hence women known to have thrombophilias (especially if multiple) should be counselled about this increased risk prior to prescription of HRT. However. HRT increases the risk of VTE about fourfold even in women without any thrombotic abnormalities: possible causes are discussed

Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation.

The death receptor, Fas, triggers apoptotic death and is essential for maintaining homeostasis in the peripheral lymphoid organs. RIP1 was originally cloned when searching for Fas-binding proteins and was later shown to associate also with the signaling complex of TNFR1. Although Fas exclusively induces apoptosis, TNFR1 primarily activates the pro-survival/pro-inflammatory NF-κB pathway. Mutations in Fas lead to lymphoproliferative (lpr) diseases, and deletion of TNFR1 results in defective innate immune responses. However, the function of RIP1 in the adult lymphoid system has not been well understood, primarily owing to perinatal lethality in mice lacking the entire RIP1 protein in germ cells. This current study investigated the requirement for RIP1 in the T lineage using viable RIP1 mutant mice containing a conditional and kinase-dead RIP1 allele. Disabling the kinase activity of RIP1 had no obvious impact on the T-cell compartment. However, T-cell-specific deletion of RIP1 led to a severe T-lymphopenic condition, owing to a dramatically reduced mature T-cell pool in the periphery. Interestingly, the immature T-cell compartment in the thymus appeared intact. Further analysis showed that mature RIP1(-/-) T cells were severely defective in antigen receptor-induced proliferative responses. Moreover, the RIP1(-/-) T cells displayed greatly increased death and contained elevated caspase activities, an indication of apoptosis. In total, these results revealed a novel, kinase-independent function of RIP1, which is essential for not only promoting TCR-induced proliferative responses but also in blocking apoptosis in mature T cells