Optimizing the Stark-decelerator beamline for the trapping of cold molecules using evolutionary strategies

We demonstrate feedback control optimization for the Stark deceleration and trapping of neutral polar molecules using evolutionary strategies. In a Stark-decelerator beamline pulsed electric fields are used to decelerate OH radicals and subsequently store them in an electrostatic trap. The efficiency of the deceleration and trapping process is determined by the exact timings of the applied electric field pulses. Automated optimization of these timings yields an increase of 40 % of the number of trapped OH radicals.Comment: 7 pages, 4 figures (RevTeX) (v2) minor corrections (v3) no changes to manuscript, but fix author list in arXiv abstrac

Working Group Report: Neutrino and Astroparticle Physics

This is the report of neutrino and astroparticle physics working group at WHEPP-8. We present the discussions carried out during the workshop on selected topics in the above fields and also indicate progress made subsequently. The neutrino physics subgroup studied the possibilites of constraining neutrino masses, mixing and CPT violation in lepton sector from future experiments. Neutrino mass models in the context of abelian horizontal symmetries, warped extra dimensions and in presence of triplet Higgs were studied. Effect of threshold corrections on radiative magnification of mixing angles was investigated. The astroparticle physics subgroup focused on how various particle physics inputs affect the CMBR fluctuation spectrum, and on brane cosmology. This report also contains an introduction on how to use the publicly available code CMBFAST to calculate the CMBR fluctuations.Comment: Prepared for the 8th Workshop on High-Energy Physics Phenomenology (WHEPP-8), IIT Mumbai, India, 5-16 Jan 200

Solar Neutrino Rates, Spectrum, and its Moments : an MSW Analysis in the Light of Super-Kamiokande Results

We re-examine MSW solutions of the solar neutrino problem in a two flavor scenario taking (a) the results on total rates and the electron energy spectrum from the 1117-day SuperKamiokande (SK) data and (b) those on total rates from the Chlorine and Gallium experiments. We find that the SMA solution gives the best fit to the total rates data from the different experiments. One new feature of our analysis is the use of the moments of the SK electron spectrum in a $\chi^2$ analysis. The best-fit to the moments is broadly in agreement with that obtained from a direct fit to the spectrum data and prefers a $\Delta m^2$ comparable to the SMA fit to the rates but the required mixing angle is larger. In the combined rate and spectrum analysis, apart from varying the normalization of the $^8$B flux as a free parameter and determining its best-fit value we also obtain the best-fit parameters when correlations between the rates and the spectrum data are included and the normalization of the $^8$B flux held fixed at its SSM value. We observe that the correlations between the rates and spectrum data are important and the goodness of fit worsens when these are included. In either case, the best-fit lies in the LMA region.Comment: 17 pages, 4 figure

Neutrino physics at accelerators

Present and future neutrino experiments at accelerators are mainly concerned with understanding the neutrino oscillation phenomenon and its implications. Here a brief account of neutrino oscillations is given together with a description of the supporting data. Some current and planned accelerator neutrino experiments are also explained.Comment: 23 pages, 24 figures. Talk given at the Corfu Summer Institute on Elementary Particle Physics 200

Quantum Isometries of the finite noncommutative geometry of the Standard Model

We compute the quantum isometry group of the finite noncommutative geometry F describing the internal degrees of freedom in the Standard Model of particle physics. We show that this provides genuine quantum symmetries of the spectral triple corresponding to M x F where M is a compact spin manifold. We also prove that the bosonic and fermionic part of the spectral action are preserved by these symmetries.Comment: 29 pages, no figures v3: minor change

Progress in neutrino oscillation searches and their implications

Neutrino Oscillation, in which a given flavour of neutrino transforms into another is a powerful tool for probing small neutrino masses. The intrinsic neutrino properties involved are neutrino mass squared difference $\Delta m^2$ and the mixing angle in vacuum $\theta$. In this talk I will summarize the progress that we have achieved in our search for neutrino oscillation with special emphasis on the recent results from the Sudbury Neutrino Observatory (SNO) on the measurement of solar neutrino fluxes. I will outline the current bounds on the neutrino masses and mixing parameters and discuss the major physics goals of future neutrino experiments in the context of the present picture.Comment: Plenary Talk, WHEPP-7, January 2002, published in Pramana, Vol. 60, 261, 200

A customizable microfluidic platform for medium-throughput modeling of neuromuscular circuits

Neuromuscular circuits (NMCs) are vital for voluntary movement, and effective models of NMCs are needed to understand the pathogenesis of, as well as to identify effective treatments for, multiple diseases, including Duchenne's muscular dystrophy and amyotrophic lateral sclerosis. Microfluidics are ideal for recapitulating the central and peripheral compartments of NMCs, but myotubes often detach before functional NMCs are formed. In addition, microfluidic systems are often limited to a single experimental unit, which significantly limits their application in disease modeling and drug discovery. Here, we developed a microfluidic platform (MFP) containing over 100 experimental units, making it suitable for medium-throughput applications. To overcome detachment, we incorporated a reactive polymer surface allowing customization of the environment to culture different cell types. Using this approach, we identified conditions that enable long-term co-culture of human motor neurons and myotubes differentiated from human induced pluripotent stem cells inside our MFP. Optogenetics demonstrated the formation of functional NMCs. Furthermore, we developed a novel application of the rabies tracing assay to efficiently identify NMCs in our MFP. Therefore, our MFP enables large-scale generation and quantification of functional NMCs for disease modeling and pharmacological drug targeting. © 2019 The Author