Chemical synthesis and study of structural and optoelectronic properties of CdS thin films: Effect of SILAR growth cycles

CdS thin films were deposited on glass substrates by using successive ionic layer adsorption and reaction (SILAR) method at room temperature. The effect of SILAR growth cycles on structural, morphological, optical and electrical properties of the films has been studied. The thickness of the deposited film is measured by employing weight difference method. The X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM) studies showed that all the films exhibit polycrystalline nature and are covered well with glass substrates. The values of average crystallite size were found to be 53 nm, 58 nm, 63 nm and 71 nm corresponding to the thin films deposited with 30, 40, 50 and 60 SILAR growth cycles respectively. From the UV–VIS spectra of the deposited thin films, it was seen that both the absorption properties and energy bandgap of the films changes with increasing number of SILAR growth cycles. A decrease of electrical resistivity has been observed with increasing SILAR growth cycles. &nbsp

Discovering High Utility Itemsets using Hybrid Approach

Mining of high utility itemsets especially from the big transactional databases is time consuming task. For mining the high utility itemsets from large transactional datasets multiple methods are available and have some consequential limitations. In case of performance these methods need to be scrutinized under low memory based systems for mining high utility itemsets from transactional datasets as well as to address further measures. The proposed algorithm combines the High Utility Pattern Mining and Incremental Frequent Pattern Mining. Two algorithms used are Apriori and existing Parallel UP Growth for mining high utility itemsets using transactional databases. The information about high utility itemsets is maintained in a data structure called UP tree. These algorithms are not only used to scans the incremental database but also collects newly generated frequent itemsets support count. It provides fast execution because it includes new itemsets in tree and removes rare itemset from a utility pattern tree structure that reduces cost and time. From various Experimental analysis and results, this hybrid approach with existing Apriori and UP-Growth is proposed with aim of improving the performance

Left ventricular noncompaction and myocardial fibrosis: a case report

<p>Abstract</p> <p>Background</p> <p>Left ventricular noncompaction (LVNC) is a rare congenital abnormality. It is currently classified as a genetic cardiomyopathy and results from early arrest of endomyocardial morphogenesis. The pathophysiology of left ventricular dysfunction, which becomes apparent beyond the 4^thdecade of life, is unclear.</p> <p>Case report</p> <p>We report a case of 60-year-old woman who presented with shortness of breath and showed noncompacted endocardium on echocardiography. Cardiac catheterization and viral studies were unremarkable. Histology revealed endomyocardial fibrosis without disarray. She was subsequently diagnosed with LVNC and treated with medications.</p> <p>Discussion</p> <p>Cardiologists and other physicians should be aware of LVNC due to its high likelihood of misdiagnosis and associated high complication rates. Early diagnosis, intervention and screening among family members can decrease the morbidity and mortality associated with LVNC.</p

Modeling of Substrate Noise Effects in Dynamic CMOS Circuits

The decrease in the feature size has led to the integration of both digital and analog circuits on the same silicon die which has led to many crosstalk issues. The crosstalk due to the substrate interactions also plagiarizes complete digital systems. This paper lays emphasis on this fact and because of the vulnerability of dynamic CMOS circuits to noise; a brief study of the effects of substrate variations on the performance of the dynamic CMOS circuits is carried out in this paper. The effects of substrate noise at very high frequencies (above 10 GHz) are also depicted in this paper. In order to accurately estimate the effects of substrate noise a substrate model is proposed and verified for functionality in the last section of this paper

A comparative study of the effects of risperidone and olanzapine on metabolic parameters of schizophrenic patients

Background: Risperidone and olanzapine are the most commonly prescribed antipsychotic drugs. There is an overwhelming need to look into the adverse effects induced by these drugs; metabolic disturbance being one of the important of them. Metabolic disturbance induced by these drugs is a little searched domain; Most of the literature on their metabolic adverse effects is based on retrospective analysis. Moreover there is a distinct lack of information on the metabolic adverse effects of these drugs in Indian subjects with special reference to rural population.Methods: The present study was a prospective, open label, observational study conducted on 189 consecutive new subjects who were prescribed either risperidone (n=93) and olanzapine (n=96) in the psychiatry department of a rural medical college and hospital.Results: Patients on treatment of risperidone (n=84) showed an increase in all the variables except for HDL cholesterol levels which showed fall. The increases in weight, body mass index were found to be extremely significant (p<0.001). While the rise in the systolic and diastolic blood pressure, fasting sugars and triglycerides, changes was not significant. The fall in HDL cholesterol was not statistically significant.Conclusions: We conclude from this study that both risperidone and olanzapine have propensity to produce metabolic syndrome in subjects who use them. When compared, olanzapine has a higher chance to produce metabolic syndrome in subjects who were prescribed it, as compared to subjects who were on risperidone

Is there a need to review the syndromic case management of vaginal discharge due to candida in the Indian scenario?

Background: Vulvovaginal candidiasis (VVC) affects approximately 75% of women once in lifetime. National AIDS Control Organization has recommended Kit-2/Green (tablet secnidazole 2 gm OD stat and capsule fluconazole 150 mg OD stat) for syndromic case management (SCM) of patients with vaginal discharge since 2007. Patients are frequently revisiting the STI centre with recurrent VVC. The purpose of the study was to determine the effectiveness of fluconazole and other azoles in vulvovaginitis. Methods: Vaginal swabs from 188 patients attending regional STI centre, at Government Medical College, Nagpur between October 2020 to June 2022 were processed. A total of 128 conventionally confirmed isolates of Candida species were tested on RPMI 1640 medium for susceptibility to azoles by E test. An MIC of ≥8 μg/ml for fluconazole and ≥1 μg/ml for itraconazole, ketoconazole and voriconazole was interpreted as resistance as per CLSI M-60. Results: Candida species isolated were Candida albicans, C. glabrata, C. tropicalis, C. parapsilosis, C. dubliniensis and C. krusei. Candida species resistant to fluconazole, itraconazole, ketoconazole and voriconazole were 22 (17.18%), 53 (41.40%), 19 (14.84%), and 3 (2.34%) respectively. C. glabrata was most resistant while C. parapsilosis was least resistant. Voriconazole was most effective. Conclusions: Extensive use of fluconazole in syndromic case management of vaginal discharge could be the probable reason for 17.18% resistance to fluconazole. Withdrawal of fluconazole and replacement with another antifungal azole in SCM of vaginal discharge may prevent recurrent VVC and perhaps lead to emergence of fluconazole sensitive candida

Recent trends in seroprevalence of syphilis in different patient groups attending a regional centre for sexually transmitted infections in central India

Background: Easy access to Suraksha clinics for sexually transmitted infections calls for a review of seroprevalence of syphilis. Methods: Serum samples from attendees of sexually transmitted infections (STI)/ reproductive tract infections (RTI) clinic/antenatal clinic, and samples of high-risk group (HRG: female sex workers and men having sex with men) brought by non-government organizations from 2017-22 were screened for syphilis by Venereal Disease Research Laboratory (VDRL) and Treponema pallidum hemagglutination (TPHA) tests. Samples positive by both tests were considered seropositive for syphilis. Statistical methods used for analysis were chi square test for linear trends and Kruskal Wallis test. Results: In STI clinic percentage positivity for syphilis has shown a statistically significant decline from 2017-22. In RTI clinic the decline was significant from 2017-19 but not significant in the years 2019-22. In antenatal clinic and in HRGs the change in seroprevalence was not significant from 2017-22 and 2017-20 respectively. However, the HRGs showed a significantly increasing trend in syphilis seropositivity from 2020-22. Conclusions: There is a significantly declining trend in the seroprevalence of syphilis in patients attending the STI/RTI clinic from 2017-22 and in HRGs from 2017-20. However, a significant increase in trend in HRG from 2020-22 may have been due to behavioural changes during the lockdown for covid 19 pandemic. A significant decline in syphilis in patients attending the STI and RTI clinic and in HRGs attending the regional centre indicates the effectiveness of consistent detection, treatment and counselling efforts of the national control program on STI in the region

NCL Implementation of Dual-Rail 2\u3csup\u3eS\u3c/sup\u3e Complement 8x8 Booth2 Multiplier using Static and Semi-Static Primitives

In this work, we use static and semi-static versions of NULL Convention Logic (NCL) primitives (i.e., threshold gates) to implement a dual-rail 8times8 2s complement multiplier using the Modified Booth2 algorithm for partial product generation and a Wallace tree for partial product summation. We establish the multiplier\u27s functionality utilizing VHDL-based simulations of the gate-level structural design. The design is then implemented at the transistor-level and layout-level using both static and semi-static threshold gates, for a 1.8V 0.18mum TSMC CMOS process; and these two implementations are compared in terms of area, power, and speed

Altered Backbone and Side-Chain Interactions Result in Route Heterogeneity during the Folding of Interleukin-1b (IL-1b)

Deletion of the b-bulge trigger-loop results in both a switch in the preferred folding route, from the functional loop packing folding route to barrel closure, as well as conversion of the agonist activity of IL-1b into antagonist activity. Conversely, circular permutations of IL-1b conserve the functional folding route as well as the agonist activity. These two extremes in the folding-functional interplay beg the question of whether mutations in IL-1b would result in changes in the populations of heterogeneous folding routes and the signaling activity. A series of topologically equivalent water-mediated b-strand bridging interactions within the pseudosymmetric b-trefoil fold of IL-1b highlight the backbone water interactions that stabilize the secondary and tertiary structure of the protein. Additionally, conserved aromatic residues lining the central cavity appear to be essential for both stability and folding. Here, we probe these protein backbone-water molecule and side chain-side chain interactions and the role they play in the folding mechanism of this geometrically stressed molecule. We used folding simulations with structure-based models, as well as a series of folding kinetic experiments to examine the effects of the F42W core mutation on the folding landscape of IL-1b. This mutation alters water-mediated backbone interactions essential for maintaining the trefoil fold. Our results clearly indicate that this perturbation in the primary structure alters a structural water interaction and consequently modulates the population of folding routes accessed during folding and signaling activity

Orbital overlap effects in electron transfer reactions across a metal nanowire/electrolyte solution interface

In this paper, we report on calculations of the orbital overlap between Fe(III) and Cr(III) aquacomplexes and different electrode surfaces: Cu(111), Ag (111), Au(111), Pt(111), and corresponding monatomic wires. The electronic structure of the monocrystalline surfaces and nanowires are described in terms of the electronic spillover and density of electronic states at the Fermi level obtained from periodic density functional theory (DFT) calculations. The transmission coefficients (κ) characterizing the first stage of outer-sphere electron transfer for the reduction of aquacomplexes are calculated on the basis of Landau–Zener theory as a function of electrode–reactant separation; the electronic transmission coefficients for the [Cr(H2O)6]3+/2+ redox couple were found to be smaller than those for [Fe(H2O)6]3+/2+. Two different intervals can be clearly distinguished for Cu, Au and Pt: “a catalytic region”, where κ(wire) > κ(Me slab) and “an inhibition region”, where κ(wire) < κ(Me slab). A similar behavior exhibits the coupling constant estimated for a hydrogen atom adsorbed at the Au(111) surface and the Au monatomic wire. These effects originate from some specific features of electronic density profile for metal nanowires: at short distances the electronic density of nanowires is higher compared with the (111) metal surfaces, while at larger separations it decreases more sharply.Fil: Nazmutdinov, Renat R.. Kazan National Research Technological University; RusiaFil: Berezin, Alexander S.. Kazan National Research Technological University; RusiaFil: Soldano, Germán. Universitat Ulm; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schmickler, Wolfgang. Universitat Ulm; Alemani