Financing of infrastructure in education : international experience of attracting private investments and opportunities for Russia to form a knowledge-driven economy

The article substantiates the role of education, proposes and confirms the hypothesis about the importance and necessity of social partnerships for financing and development of education in knowledge- driven economy. To confirm the advanced hypotheses we studied the evolution of concepts of social interaction and social responsibility to justify patterns of social partnerships in the knowledge-driven economy that allowed us, using the model of "triple helix", to show the necessity of the collaboration of government, universities and corporations to advance on the path of innovative development. We considered the industrial districts as territories, which act as a space of coordination of actors, to whom the solution of new production problems is impossible without direct interaction with universities. The lack of budget funds for the development of education requires a search for other sources of funding for infrastructure facilities in education. We revealed the mechanisms of attraction of private funding of educational institutions in Russia, arising challenges, and possible solutions. The article considers the application of concession as a form of public – private partnerships in preschool education, which recently has found application in Russia. Based on studying world best practices, the authors propose to use the investment funds, in particular, the mechanism of impact investment in education as a promising technology. Improvement of Russian legislation concerning investment funds will create the foundation for wide application of exchange-traded mutual funds for collective investments in social infrastructure. Formation of trust funds and grants to finance education becomes widespread in Russia.peer-reviewe

The study of the role of genetic polymorphisms of cytokines in the hyperplastic uterogenic processes formation

The aim of the study was to investigate the role of molecular-genetic markers of cytokines in the formation of hyperplastic processes in uterusyesБелгородский государственный университе

ПРИВЛЕЧЕНИЕ ЧАСТНЫХ ИНВЕСТИЦИЙ В ОБРАЗОВАНИЕ КАК ФАКТОР РАЗВИТИЯ ЭКОНОМИКИ ЗНАНИЙ

The article considers the role of education and the need for social partnership toFinance and development in an economybased on knowledge. Focuses on thestudy of mechanisms for attracting privatefinancing of educational organizations inRussia, the problems are discussed andpossible ways of their solution. Examinespublic-private partnership, the form of itsimplementation in early childhood education. Provides a mechanism for the impactof investment in education as a promisingtechnology.В статье обоснована роль образования и необходимость социального партнёрства для его финансирования и развития в условиях экономики, основанной на знаниях. Основное внимание сосредоточено на изучении механизмов привлечения частного финансирования образовательных организаций в России, возникающие при этом проблемы и возможные пути их решения. Рассматривается государственно-частное партнёрство, формы его реализации в дошкольном образовании. Предлагается механизм импактинвестированиявобразование как перспективная технология

Assessment of senior dental students and dental residents in matters of antimicrobial chemotherapy

This article highlights the results of the study designed to assess knowledge of senior dental students of medical schools and dental residents on the main issues of antibiotic therapy and the empirical use of antimicrobials for treatment of respiratory disorde

Examination of evidence for collinear cluster tri-partition

In a series of the experiments at different time-of-flight spectrometers of heavy ions we have observed manifestations of a new at least ternary decay channel of low excited heavy nuclei. Due to specific features of the effect, it was called collinear cluster tri-partition (CCT). The experimental results obtained initiated a number of theoretical articles dedicated to different aspects of the CCT. We compare theoretical predictions with our experimental data, only partially published so far. The model of one of the most populated CCT modes that gives rise to the so called "Ni-bump" is discussed. Detection of the 68-72Ni fission fragments with a kinetic energy E<25 MeV at the mass-separator Lohengrin is proposed for an independent experimental verification of the CCT.Comment: 16 pages, 14 figure

Experimental justification of new way of pharmacological correction for contact frostbite using dslet opioid peptide and serotonin adipinate to enhance surgycal treatmen

In the course of the study when assessing the microcirculatory changes caused by the simulation of frostbite, the most pronounced effect of the combined treatment of Serotonin adipinate 4.5 mg/kg and opioid peptide DSLET 10 μg/kg compared with monotherapy with the studied drugs was estimated. The most effective correction of indices of oxidantantioxidant protection observed with the combination of necrectomy with a combination of Serotonin adipinate and opioid peptide DSLET, which was confirmed by approximating the indicators of malondialdehyde, superoxide dismutase, finite stable metabolites of nitrogen oxide, total antioxidant activity and catalase to the values of intact animals on the 14th day of the experiment and reducing the level of proinflammatory cytokines (interleukin-6, tumor necrosis factor-alpha) in 2 times (p < 0.05) compared to the Control grou

A NEW METHOD BASED ON THE USE OF IMMOBILIZED SINGLE-DOMAIN ANTIBODIES TO REMOVE CERTAIN MAJOR PROTEINS FROM BLOOD PLASMA HELPS TO REDUCE NONSPECIFIC SIGNAL IN AN IMMUNOASSAY

A generally underestimated problem of immunoassays is its susceptibility to various interferences, being the Achilles heel of these assays (interventions in the analysis). The presence of interfering substances in the patient’s specimen can cause erroneous test sample result, which may lead to incorrect diagnosis and catastrophic consequences for the patient. Hence, one should pay particular attention to identifying possible interferences in the test systems used and, when possible, develop and apply methods to overcome them. The issue of avoiding interference is particularly important for immunoassays of biomarkers in human plasma or serum. In order to reduce possible interferences, it would be desirable to have an opportunity of specific and adaptable pretreatment of blood samples for a specifically assayed marker protein, as applied to a specific test system. We assume that such pretreatment may be done by combining the immunosorbents based on the use of special single-domain antibodies (nanobodies).The nanobodies are recombinant proteins, derivatives of single-domain antigen-recognizing variable fragments of specific antibodies, consisting of a dimer of truncated heavy chains in the complete absence of light chains. Such specific antibodies are detectable in the normal samples taken from members of the Camelidae family (Camelids), and in some species of cartilaginous fishes, along with the common antibodies. The special properties of nanobodies can provide certain advantages in their use, compared with antibodies of traditional structure and their derivatives.In this paper, we have shown for the first time, that the immunosorbents based on certain combination of single-domain antibodies used as ligands able for specifically binding and removal of specific high-abundance human blood proteins, may be selected for a given marker blood antigen in such a way that they will be an effective tool for blood pretreatment, aiming to reduce possible effects of interference and increased sensitivity in the diagnostic “sandwich” enzyme immunoassay. A new method of plasma pretreatment is demonstrated with human plasma samples (at a dilution of 1:40) of two patients. A previously developed model system for detection of lactoferrin protein was used to analyze plasma samples. It is shown that a significantly increased ratio of total detected signal to the nonspecific background signal could be obtained after drastic reduction of this background by affinity removal of 3 major protein fractions, i.e., fibrinogen, IgG alpha-2-macroglobulin from blood plasma samples, using appropriate immobilized single domain antibodies

Induction of ovarian steroidogenesis as an additional potential risk factor for progression in premenopausal patients with hormone-receptor-positive breast cancer receiving tamoxifen as adjuvant therapy

Introduction. Patients with hormone-receptor-positive (HR+) breast cancer (BC) over 40 years old who take tamoxifen are not subject to mandatory castration. However this cohort of patients is not homogeneous.Aim. The present study is aimed at studying the features of ovarian steroidogenesis in perimenopausal breast cancer patients receiving adjuvant hormone therapy (HT) with tamoxifen.Materialy and methods. The study included 82 patients aged 42 to 53 years with GH+BC who received HT with tamoxifen 20 mg daily. Within 9 months from the start of HT in patients, the levels of estradiol and follicle-stimulating hormone in the peripheral blood were studied every 3 months.Results. In 66.7% of patients who received chemotherapy (CT), the development of amenorrhea was noted. Half of the patients in the HT-only group demonstrated amenorrhea. Oligomenorrhea was observed in 20.8% and 16.7% in each group, respectively. The incidence of amenorrhea in women treated with chemotherapy was higher (OR 2.02; 95% CI: 0.73-5.67), but the differences were not statistically significant (p = 0.1766). In the general cohort, in 15.7-16.8% of patients, the level of estradiol exceeded 251 pg / ml - the upper limit of the norm of the follicular phase of the menstrual cycle. Differences between groups in the incidence of estradiol levels &gt; 251 pg/ml were statistically significant (p = 0.0293). 3.4-5.6% of patients in the total cohort (depending on the period of observation) had an estradiol level &gt; 649 pg / ml, which corresponded to the highest ovulatory value.Conclusions. Against the background of HT with tamoxifen in some perimenopausal patients hyperestrogenism is observed which indicates the implementation of the effect of induction of ovarian steroidogenesis and can be considered as an additional potential risk factor for the progression of HR+BC. Amenorrhea after CT is not a reliable marker of ovarian suppression

Scission Point Calculations and Physical Treating of the 'Ni-bump' in 252Cf (sf)

In a series of the experiments at different time-of-flight spectrometers of heavy ions we have observed manifestations of a new at least ternary decay channel of low excited heavy nuclei. Due to specific features of the effect, it was called collinear cluster tri-partition (CCT). The experimental results obtained initiated a number of theoretical articles dedicated to different aspects of the CCT. In the report we compare the theoretical predictions with our experimental data, only partially published so far. The developed model of one of the most populated CCT modes that gives rise to the so called “Ni-bump” is discussed

Evolution of the CDK4/6 inhibitor abemaciclib: from palliative to adjuvant therapy. Clinical experience with abemaciclib in patients with hormone-receptor-positive, HER2-negative breast cancer

Introduction. Cyclin-dependent kinase 4/6 inhibitors are indicated in endocrine therapy for the treatment of hormone receptorpositive, HER2-negative, advanced, or metastatic breast cancer. In the recent past, abemaciclib made its debut as a combinatorial partner for adjuvant therapy in hormone-dependent breast cancer. This article demonstrates the analysis of our own experience of introducing abemaciclib into clinical practice.Aim. The aim of the study was to evaluate the preliminary results of treatment of patients with hormone receptor-positive HER2-negative metastatic breast cancer using abemaciclib outside the framework of clinical trials, in the real clinical practice of an oncological dispensary.Materials and methods. A retrospective analysis of the results of treatment was carried out in 27 patients who were prescribed abe-maciclib in various regimens and lines from April 2021 to January 2022 in the conditions of routine practice in the Krasnodar region.Results and discussion. Analysis of the total population of 27 patients at a median follow-up of 8 months showed that the median PFS was not reached. The one-year PFS was 68.8%. Treatment outcomes were independent of prescribing abemaciclib to treat baseline metastatic disease or breast cancer progression after previous radical treatment (p = 0.60). The PFS did not depend on the expression of progesterone receptors in the tumor tissue (p = 0.326) and the proliferative activity index Ki-67 (p = 0.618). Patients who received no more than 2 lines of previous drug treatment for a history of metastatic breast cancer had the greatest benefit from abemaciclib therapy (p = 0.001).Conclusions. Despite a relatively difficult group of patients (96% of patients with visceral metastases), abemaciclib has demonstrated efficacy and safety. The effectiveness did not depend on the analyzed factors: Ki-67, the level of expression of progesterone receptors, the type of metastatic disease (de novo metastatic or progressive breast cancer). In view of the best results, it is advisable to prescribe abemaciclib in the early lines of therapy