The aim of the study was to investigate the role of molecular-genetic markers of cytokines in the formation of hyperplastic processes in uterusyesБелгородский государственный университе

Altuhova, O.

Churnosov, M.

Goryainova, N.

Koneva, O.

Krikun, E.

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S54 4th International Symposium o f Clinical and Applied Anatomy (ISCAA), 28 June-1 July 2012, Ankara, TurkeyP-50The study of the role of genetic polymorphisms of cytokines in the hyperplastic uterogenic processes formationGoryainova N*, Altuhova O*, Koneva O*, Churnosov M*, Krikun E**, Kapustin R****Department o f Medical and Biological Sciences, Belgorod State University, Belgorod, Russia; **Department o f Human Anatomy and Histology, Belgorod State University, Belgorod, Russia; ***Department of Animal Morphology, Belgorod State Agricultural Academy, Maiskii, RussiaThe aim of the study was to investigate the role of molecular- genetic markers of cytokines in the formation of hyperplastic processes in uterus. Twenty genetic polymorphisms were geno- typed [-308 G/A TNFa, +250 A/G L ta +36A/G by TNFR1, - 322VNTR TNFR2,-889 C/T IL -  1A,-511 With/t IL-1B, IL- 1RA,-584C/t IL4, - 703C/T IL-5,-174 G/C IL-6,-251 A/T IL-8, - T113M IL-9,-592 C/A IL10, A/T MIP-1 (rs1719153), +764 G/with MCP-1,-801 G/A SDF-1, G/A I-tac (rs4512021), -403 G/A RANTES, C/T MIG (rs28694761), C/T IP-10 (rs867562)]. The investigated sample included 687 patients with hyperplastic uterogenics processes (hysteromyoma n=221, adenomyosis n=223, endometrial hyperplasia n=243) and 246 women of population control. The molecular and genetic markers, which associated with formation of hyperplastic processes in uterus, were identified. Risk factors for hysreromyoma were: +250GG L ta  (OR = 2.74, R = 0.005); - 889C IL -  1A (OR = 1.37, R = 0.02); - 889CC IL -  1A (OR = 2.32, R = 0.04), endometrial hyperplasia - +36AG TNFR1 (OR =1.87, R = 0.002). The concentration of genotype +36 GG TNFR1 (5.13 %) for patients with hysreromyoma accompanied with adenomyosis, was four times less compared with the control group (22.93%, p=0.048), and the differences in frequency of allele +36 G TNFR1, between these groups, reached 150% (p=0.006). Patients with hysteromyoma, accompanied by hyperplastic utero- genics processes, had high frequency of genitals inflammatory dis­eases (85.71%, p=0.013) and the greatest prevalence of the genet­ic markers-308 and (17.33%) and - 308 AA T N Fa (8.00%) (OR=1.91 - 13.57, p=0.03). The maximum concentration of these markers was observed in cases when the hysteromyoma was accompanied by the polip of endometrium.Keywords: Hyperplastic processes, molecular-genetic markers P-51Correlation in blood supply to bladder and prostate during various phases of vesical functional activityKabanova I*, Kirpatovsky V*, Kapustin R***Department o f Experimental Urologic Disease Modelling, Research Institute o f Urology, Moscow, Russia; * *Department o f Animal Morphology, Belgorod State Agricultural Academy, Maiskii, RussiaTo study peculiarities of hemodynamics in prostate and uri­nary bladder in dependence on bladder filling with the help of high resolution impedancometry and harmonic analysis. In experiments with mature random bred dogs (n=4) and rats (n=11), the small variations of vesical and prostatic impedance were recorded and analyzed with harmonic (Fourier) techniquein the void bladder and during its progressive filling via a cystostomy tube. Simultaneously, intravesical pressure and ECG were recorded. Blood supply to these organs was assessed with effective pulsatile impedance (EPI) derived from the cardiac har­monics in the impedance spectrum. Both dogs and rats demon­strated similar changes in blood supply to the examined organs. During bladder filling, the intravesical pressure rose from 2.6±0.9 to 36.7±4.8 cmH2O in rats and dogs. During filling, vesical EPI increased by 48±8% in rats and by 53±9% in dogs. At the same time, prostatic EPI decreased by 49±7% in rats and by 77±10% in dogs. The urinary bladder and prostate in dogs and rats demonstrate the opposite changes in blood supply dur­ing progressive filling and voiding of the bladder.Keywords: Impedance, prostate, urinary bladder, blood supply P-52Age's x-ray anatomy of skeleton scapular w aist and forlimb of sheep prikatunsky type Gornoaltay breed in postnatal ontogenesisRydinskaya N*, Galtsova Z*, Kapustin R***Department o f Animal Anatomy and Histology, Altai State Agricultural University, Barnaul, Russia, **Department o f Animal Morphology, Belgorod State Agricultural Academy, Maiskii, RussiaThe purpose of the research is to find durations of appearance focuses of ossification bones of scapular waist, stylopodium (humerus), zeygopodium (forearm) and autopodium (proximal phalanx) of sheep of Prikatunsky type in postnatal ontogenesis. The samples were taken from nine sheep of Prikatunsky type of Gornoaltay breed at age of 1, 4 and 12, months of Altai (Russian gerion). Proximal phalanx, of a one month old sheep has lateral and medial focuses of ossification in both distal and proximal parts. An X-ray of a 4 month old sheep shows, that the scapula still consists of 60% of cartilage. The humerus still has synhon- drosis between the collum and the caput. Along the perimeter of semilunar incisur a solid architectonic is observable. Proximal epyphisis matches with metaphysic and suture is in the phase of ossification. 70 % of scapula of 12 month old sheep underwent the process of ossification, synhondrosis are not visible. On lat­eral surface of humerus there is a small part of metaphysis carti­lage. Ossification of skeleton scapular and forelimb of pricatun- sky type sheep of Gornoaltaysky breed skeleton scapular and forelimb is almost fully ended at age 12 months.Keywords: Sheep, X-ray, ossification, development, boneP-53The role of Ivan Alekseevich Dvigubskiy in Russian mor­phological terminology of animals formationKapustin R, Shilo EDepartment o f Animal Morphology, Belgorod State Agricultural Academy, Maiskii, RussiaIvan Alekseevich Dvigubskiy - physicist, zoologist, botanist, paleontologist, geologist and geographer, doctor of medicine, rector of the Moscow University, honored professor of physicsAnatomy 2012; 6 Suppl

The study of the role of genetic polymorphisms of cytokines in the hyperplastic uterogenic processes formation

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The study of the role of genetic polymorphisms of cytokines in the hyperplastic uterogenic processes formation

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