Osteonecrosis maxilar y bisfosfonatos: presentación de tres nuevos casos

Los bisfosfonatos están adquiriendo una relevancia terapéutica cada vez mayor, dada su utilidad en el manejo de diversas patologías. Con el incremento de su uso, se están documentando casos de necrosis ósea mandibular, y en menor medida maxilar, de difícil solución y con una importante afectación de la calidad de vida de los pacientes en tratamiento con estos fármacos. El factor que con mayor frecuencia desencadena el proceso es la actuación de los profesionales: odontólogos, estomatólogos y cirujanos orales y maxilofaciales. La previsión, las intervenciones atraumáticas y el tratamiento conservador, parecen ser los medios más adecuados para minimizar la incidencia o resolver las complicaciones. Este artículo presenta tres casos, seguidos por nuestro servicio, de pacientes con necrosis ósea maxilar tras procedimientos dentales, fundamentalmente exodoncias. El conocimiento de este posible efecto secundario de los bisfosfonatos debería ser tenido en cuenta antes de cualquier intervención en este tipo de pacientes.Bisphosphonates are recently acquiring increasing relevance in the treatment of several diseases. In line with the increased use of these compounds, cases of mandibular osteonecrosis, and to a lesser extent, maxillary osteonecrosis, are being reported. This necrosis is difficult to treat in patients who usually have a previously limited quality of life. A surgical performance carried out by oral and maxillofacial surgeons, stomatologists and odontologists might lead to bone exposure. A treatment based on conservation and as harmless as possible seems to be the most advisable way of acting with these patients in order to minimize the incidence and treat the complications, once the lesions have been ascertained. We report three cases treated in our service of osteonecrosis of the jaws after exodontics. This side effect should be remembered before starting any surgical treatment in these patients

Osteonecrosis of the jaws and bisphosphonates : Report of three cases

Bisphosphonates are recently acquiring increasing relevance in the treatment of several diseases. In line with the increased use of these compounds, cases of mandibular osteonecrosis, and to a lesser extent, maxillary osteonecrosis, are being reported. This necrosis is difficult to treat in patients who usually have a previously limited quality of life. A surgical performance carried out by oral and maxillofacial surgeons, stomatologists and odontologists might lead to bone exposure. A treatment based on conservation and as harmless as possible seems to be the most advisable way of acting with these patients in order to minimize the incidence and treat the complications, once the lesions have been ascertained. We report three cases treated in our service of osteonecrosis of the jaws after exodontics. This side effect should be remembered before starting any surgical treatment in these patients

Mesh size and effort changes in multispecies fisheries in ICES Divisions Vlllc and IXa.

Different simulations varying trawl mesh size and effort changes for several fishing units in ICES Divisions VIllc and IXa were carried out. Landings included in the analysis represent most of the catches in the southern area defined as the management unit for hake, megrim; monkfish, horse mackerel, blue whiting and mackerel. Three Nephrops stock s in Divisions Vlllc and IXa are also included. These species are mainly exploited by Spanish and Portuguese fleets, using various fishing gears to exploit different fractions of the populations, and for this reason nine fishing units were used in the analysis

Fisheries and Prestige. Review and update of studies on the effects of the Prestige oil spill

The Prestige oil tanker sank in November 2002 and leaked around 60 000 mt. of heavy oil (type M-100) into the sea. Immediately after the accident, closed areas were established. Among the fleets affected by the closures were four of the most important in ICES Division VIIIc and Sub-division IXa North (bottom trawl, pair trawl, purse seine targeting sardine and hand line targeting mackerel) as they exploit considerable resources, some outside biological safety limits. A fall in effort was observed in all of them, mainly in the first quarter and in sub-divisions VIIIc West and IXa North, although it failed to lead to a very large reduction in the total annual effort of each of the fleets, with the exception of hand line. Pair trawlers can make two types of fishing trip, but differences in specific composition among the three years analysed were not found in either of them. In the case of trawl, five kinds of fishing trips were identified, and changes were only found in the type that targets Norway lobster, hake, megrim and monk (HMMN), with a fall in the presence of Norway lobster

Cambios de malla y esfuerzo en las pesquerías multiespecíficas en aguas atlánticas de la península Ibérica

Se han realizado diferentes ensayos de cambios de malla y esfuerzo para varias unidades pesqueras de las divisiones VIIIc y IXa del CIEM (Consejo Internacional pqra la Exploración del Mar). Los desembarcos incluidos en este análisis representan la mayoría de las capturas de las especies de merluza, gallos, rapes, jurel, lirio y caballa en la zona sur, definida como unidad de gestión. Están también incluidos tres stocks de cigala de estas divisiones. Dichas especies son las principales especies explotadas por las flotas española y portuguesa, que usan diferentes tipos de artes para explotar diferentes fracciones de las poblaciones. Por esta razón en el presente análisis se utilizaron nueve unidades pesqueras.Different simulations varying trawl mesh size and effort changes for several fishing units in ICES Divisions VIIIc and IXa were carried out. Landings included in the analysis represent most of the catches in the southern area defined as the management unit for hake, megrim, monkfish, horse mackerel, blue whiting and mackerel. Three Nephrops stocks in Divisions VIIIc and IXa are also included. These species are mainly exploited by Spanish and Portuguese fleets, using various fishing gears to exploit different fractions of the populations; for this reason, nine fishing units were used in the analysis.Versión del editor0,000

Proteasome Nuclear Import Mediated by Arc3 Can Influence Efficient DNA Damage Repair and Mitosis in Schizosaccharomyces Pombe

Proteasomes must efficiently remove their substrates throughout the cells in a timely manner as many of these proteins can be toxic. This study shows that proteasomes can do so efficiently because they are highly mobile. Furthermore this study uncovers that proteasome mobility requires functional Arc3, a subunit of the Arp2/3 complex