Chemical induction of spawning by serotonin in the ocean quahog Arctica islandica (Linne)

Serotonin injected into the anterior adductor muscle induced spawning in the ocean quahog Arcrica islandica (Linne) when using either individual or mass spawning techniques. This represents the fir st successful attempt to induce the release of gametes in this species which historically has been unresponsive to conventional spawning stimuli. The gametes released were competent and fertilization occurred without treating the encapsulated eggs with ammonium hydroxide or other chemicals. Larvae were reared through metamorphosis to early juvenile stage

Direct measurements of ice-shelf flexure caused by surface meltwater ponding and drainage.

Global sea-level rise is caused, in part, by more rapid ice discharge from Antarctica, following the removal of the restraining forces of floating ice-shelves after their break-up. A trigger of ice-shelf break-up is thought to be stress variations associated with surface meltwater ponding and drainage, causing flexure and fracture. But until now, there have been no direct measurements of these processes. Here, we present field data from the McMurdo Ice Shelf, Antarctica, showing that the filling, to ~2 m depth, and subsequent draining, by overflow and channel incision, of four surface lakes causes pronounced and immediate ice-shelf flexure over multiple-week timescales. The magnitude of the vertical ice-shelf deflection reaches maxima of ~1 m at the lake centres, declining to zero at distances of <500 m. Our results should be used to guide development of continent-wide ice-sheet models, which currently do not simulate ice-shelf break-up due to meltwater loading and unloading.This work was supported by the U.S. National Science Foundation under award PLR-1443126 to the University of Chicago, a Leverhulme Early Career Fellowship (ECF-2014-412) and a CIRES Postdoctoral Visiting Fellowship, both awarded to A.F.B., and a NASA Earth and Space Science Fellowship (NNX15AN44H) awarded to G.J.M

Preliminary observations on the usefulness of hinge structures for identification of bivalve larvae

Difficulties associated with discrimination of bivalve larvae isolated from plankton samples have long hampered both applied and basic research efforts in estuarine and open coastal marine environments. The vast majority of practical barriers to identification of larval bivalves may be eliminated through routine optical microscopic examination of the hinge apparatus of disarticulated larval shells. Representative micrographs of various ontogenetic stages of larval hinge development are presented for 12 genera (Mytilus, Geukensia, Crassostrea, Placopecten. Argopecten. Mya, Spisula, Mulinia, Ensis, Arca, Arctica. and Mercenaria) from 9 bivalve superfamilies (Mytilacea, Ostreacea. Pectinacea, Myacea, Mactracea. Solenacea, Arcacea, Arcticacea. and Veneracea). The larval hinge apparatus (provinculum). by itself is generally useful for superfamilial separation. When coupled with a consideration of gross shell shape, detailed examination of hinge line structures often permits generic or even specific, identification. A format is suggested for organization of qualitative morphological life history data that will provide an adeqate basis for comparison of the larval stages of various species of bivalves

A computational analysis of Turkish makam music based on a probabilistic characterization of segmented phrases

This study targets automatic analysis of Turkish makam music pieces on the phrase level. While makam is most simply defined as an organization of melodic phrases, there has been very little effort to computationally study melodic structure in makam music pieces. In this work, we propose an automatic analysis algorithm that takes as input symbolic data in the form of machine-readable scores that are segmented into phrases. Using a measure of makam membership for phrases, our method outputs for each phrase the most likely makam the phrase comes from. The proposed makam membership definition is based on Bayesian classification and the algorithm is specifically designed to process the data with overlapping classes. The proposed analysis system is trained and tested on a large data set of phrases obtained by transferring phrase boundaries manually written by experts of makam music on printed scores, to machine-readable data. For the task of classifying all phrases, or only the beginning phrases to come from the main makam of the piece, the corresponding F-measures are.52 and.60 respectively.Scientific and Technological Research Council of Turkey, TUBITAK (112E162

Intersecting Brane Worlds at One Loop

We develop techniques for one-loop diagrams on intersecting branes. The one-loop propagator of chiral intersection states on D6 branes is calculated exactly and its finiteness is shown to be guaranteed by RR tadpole cancellation. The result is used to demonstrate the expected softening of power law running of Yukawa couplings at the string scale. We also develop methods to calculate arbitrary N-point functions at one-loop, including those without gauge bosons in the loop. These techniques are also applicable to heterotic orbifold models.Comment: 35 pages, 3 figures; added reference, corrected typos, JHEP styl

Supersymmetry in the shadow of photini

Additional neutral gauge fermions -- "photini" -- arise in string compactifications as superpartners of U(1) gauge fields. Unlike their vector counterparts, the photini can acquire weak-scale masses from soft SUSY breaking and lead to observable signatures at the LHC through mass mixing with the bino. In this work we investigate the collider consequences of adding photini to the neutralino sector of the MSSM. Relatively large mixing of one or more photini with the bino can lead to prompt decays of the lightest ordinary supersymmetric particle; these extra cascades transfer most of the energy of SUSY decay chains into Standard Model particles, diminishing the power of missing energy as an experimental handle for signal discrimination. We demonstrate that the missing energy in SUSY events with photini is reduced dramatically for supersymmetric spectra with MSSM neutralinos near the weak scale, and study the effects on limits set by the leading hadronic SUSY searches at ATLAS and CMS. We find that in the presence of even one light photino the limits on squark masses from hadronic searches can be reduced by 400 GeV, with comparable (though more modest) reduction of gluino mass limits. We also consider potential discovery channels such as dilepton and multilepton searches, which remain sensitive to SUSY spectra with photini and can provide an unexpected route to the discovery of supersymmetry. Although presented in the context of photini, our results apply in general to theories in which additional light neutral fermions mix with MSSM gauginos.Comment: 23 pages, 8 figures, references adde

The mRNA expression of SETD2 in human breast cancer: Correlation with clinico-athological parameters

BACKGROUND: SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes. Therefore, it could be implicated in the process of carcinogenesis. Furthermore, this gene is located on the short arm of chromosome 3p and we previously demonstrated that the 3p21.31 region of chromosome 3 was associated with permanent growth arrest of breast cancer cells. This region includes closely related genes namely: MYL3, CCDC12, KIF9, KLHL18 and SETD2. Based on the biological function of these genes, SETD2 is the most likely gene to play a tumour suppressor role and explain our previous findings. Our objective was to determine, using quantitative PCR, whether the mRNA expression levels of SETD2 were consistent with a tumour suppressive function in breast cancer. This is the first study in the literature to examine the direct relationship between SETD2 and breast cancer. METHODS: A total of 153 samples were analysed. The levels of transcription of SETD2 were determined using quantitative PCR and normalized against (CK19). Transcript levels within breast cancer specimens were compared to normal background tissues and analyzed against conventional pathological parameters and clinical outcome over a 10 year follow-up period. RESULTS: The levels of SETD2 mRNA were significantly lower in malignant samples (p = 0.0345) and decreased with increasing tumour stage. SETD2 expression levels were significantly lower in samples from patients who developed metastasis, local recurrence, or died of breast cancer when compared to those who were disease free for > 10 years (p = 0.041). CONCLUSION: This study demonstrates a compelling trend for SETD2 transcription levels to be lower in cancerous tissues and in patients who developed progressive disease. These findings are consistent with a possible tumour suppressor function of this gene in breast cancer