What research we no longer need in neurodegenerative disease at the end of life : The case of research in dementia

A complete silence. That was what we got back from the European experts who had been energetically discussing research priorities in palliative care in neurodegenerative disease (ND) until a short while ago.1 The chair, an entertaining professor with good manners, must have felt the unease and quickly refocused the group to their task. But, wasn’t this the best question of all day? What research we no longer need? As scientists able to consider different perspectives, shouldn’t we have some idea of what research is, by contrast, no longer necessary? Palliative care research and research with people who have ND and are at the end of their life is, by definition, difficult. Making choices is a sensitive issue, but funds are limited. Therefore, we take a counterpoint to the research agenda recently reported by European Union (EU) Joint Programme – Neurodegenerative Disease Research (JPND),1 and consider whether there are studies we no longer need or are low priority, taking the example of dementiaPeer reviewedFinal Accepted Versio

Jenny Goodman to Mr. James Meredith (6 October 1962)

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Components of palliative care interventions addressing the needs of people with dementia living in long term care: a systematic review

© The Author(s) 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).Background: People with dementia requiring palliative care havemultiple needs that require complex, multicomponent interventions. Thisneed is amplified in the long term care setting. The European Associationfor Palliative Care (EAPC) White Paper offers recommendations forpalliative care in dementia and highlights domains of care integral forthis population, thus providing useful guidance to developing suchinterventions. This review maps components of palliative careinterventions for people with dementia in LTCFs, with a particular focuson shared decision-making.Peer reviewe

Collective memories, place-framing and the politics of imaginary futures in sustainability transitions and transformation

A geographical perspective is crucial to understanding sustainability transitions and transformation, but previous research on place framing in sustainability transitions and transformation has had a marked focus on the politics of the future and its performativity in the present. This paper analyzes place-framing in sustainability transitions and transformation by examining how the conflicting collective memories of a place and the framings of the future of this place interact and lead to the justification of particular forms of socio-material development, land use and sustainability of the peri-urban spaces of the city of Sogamoso, Colombia. Based on 38 semi-structured interviews, we identify three distinct assemblages of future visions, collective memories and place frames, which we call urban development, recovering tradition, and cultural revitalization. The analysis shows that place framing is an exercise through which collective memories and future visions are connected and co-constituted in a spatio-temporal ‘dialogue’: collective memories, future visions and place frames are processes of social construction activated in the attempt to shape or contest sustainability transitions and transformation. We contend that the existence and mobilization of collective memories—and their critical influence on future visions—are a core aspect of the politics of place framing fundamental to the socio-material processes of sustainability transitions and transformation. Furthermore, a politics of place-making in sustainability transitions and transformation involves acknowledging and negotiating collective memories of the past as much as future visions. This suggests ways to critically counterbalance the marked future orientation taken in recent years by sustainability science and transition studies

Collective memories, place-framing and the politics of imaginary futures in sustainability transitions and transformation

A geographical perspective is crucial to understanding sustainability transitions and transformation, but previous research on place framing in sustainability transitions and transformation has had a marked focus on the politics of the future and its performativity in the present. This paper analyzes place-framing in sustainability transitions and transformation by examining how the conflicting collective memories of a place and the framings of the future of this place interact and lead to the justification of particular forms of socio-material development, land use and sustainability of the peri-urban spaces of the city of Sogamoso, Colombia. Based on 38 semi-structured interviews, we identify three distinct assemblages of future visions, collective memories and place frames, which we call urban development, recovering tradition, and cultural revitalization. The analysis shows that place framing is an exercise through which collective memories and future visions are connected and co-constituted in a spatio-temporal ‘dialogue’: collective memories, future visions and place frames are processes of social construction activated in the attempt to shape or contest sustainability transitions and transformation. We contend that the existence and mobilization of collective memories—and their critical influence on future visions—are a core aspect of the politics of place framing fundamental to the socio-material processes of sustainability transitions and transformation. Furthermore, a politics of place-making in sustainability transitions and transformation involves acknowledging and negotiating collective memories of the past as much as future visions. This suggests ways to critically counterbalance the marked future orientation taken in recent years by sustainability science and transition studies

Ordinary land grabbing in peri-urban spaces: land use conflicts and governance in a small Colombian city

Recent scholarship on ‘urban land grabbing’ has urged researchers to take more geographically nuanced perspectives on land appropriation, especially in the global South. In this, there is the need to understand the actions of and interactions amongst a multiplicity of local actors—beyond large-scale investors and global cities—when considering land grabs in the spaces of urban development. Therefore, this paper analyses what—in building on the work of Ojeda (2016)—we conceptualise as the more ‘gradual’ and ‘ordinary’ driving factors of land use conflict and dispossession in the peri-urban spaces of the small-scale city of Sogamoso, Colombia. Based on participant observation fieldwork and 38 semi-structured key-informant interviews between 2017 and 2018, we first situate our findings within debates on peri-urban landscape governance and conflict and urban environmental politics in Latin America and Colombia. We then explore the ways that the everyday, livelihood practices of agriculture, mining and ecological conservation are in tension with urban expansionism and land grabbing within the urban and peri-urban spaces. In particular, we found that these tensions are facilitated by local policy incoherence and the failures of municipal, place-based policies and politics: Policy confusion, incoherence and capture by elites results in normative uncertainty and weak environmental governance while a lack of coordinated municipal governance in peri-urban spaces leads to further confusion and an exacerbation of already unequal, grounded power relations. Both lead to gradual and more ordinary processes of land grabbing by powerful actors in Sogamoso to the detriment of the livelihoods of citizens and ecological conservation in peri-urban spaces. In short, focusing on these often unnoticed, place-based and internally-dynamic forces of landscape conflict within the city of Sogamoso brings to the fore the everyday actions, actors and power relationships involved in urban expansionism, mining, farming and ecosystems conservation as these practices seek to coexist and compete for the same, relatively sparse amount of peri-urban space. The paper makes a substantial empirical and theory-building contribution to understanding the shifting urban geographies and environmental governance of the cities of the Global South through the day to day local scale governance of urban land use conflicts and land grabbing from the perspective of peri-urban landscapes in the small-scale city of Sogamoso, Brazil

Active blood parasite infection is not limited to the breeding season in a declining farmland bird

Avian blood parasites can have significant impacts on adult breeding birds but studies of parasitism outside the breeding season are rare, despite their potentially important implications for host–parasite dynamics. Here we investigate temporal dynamics of blood parasite infection in adult yellowhammers Emberiza citrinella. We screened blood samples collected between December and April of 2 consecutive winters using PCR. We found a high prevalence of both Haemoproteus and Leucocytozoon parasites, with a mean prevalence of 50% across 2 winters. Prevalence of both parasites was higher during the second, colder winter of the study. Temporal trends differed between the 2 genera, suggesting that chronic Haemoproteus infections gradually disappear throughout the winter but that Leucocytozoon infections exhibit a relapse during late winter, possibly coincident with reduced food availability. Our results highlight the difference in temporal dynamics between 2 blood parasite genera infecting the same host population and emphasize the need for accurate assessment of infection status at appropriate time periods when examining impacts of, and associations with, blood parasite infection. We suggest that further research should investigate the implications of over-winter infection for birds’ physiology, behavior, and survival

High rates of infection by blood parasites during the nestling phase in UK Columbids with notes on ecological associations

Studies of blood parasite infection in nestling birds rarely find a high prevalence of infection. This is likely due to a combination of short nestling periods (limiting the age at which nestlings can be sampled) and long parasite prepatent periods before gametocytes can be detected in peripheral blood. Here we examine rates of blood parasite infection in nestlings from three Columbid species in the UK. We use this system to address two key hypotheses in the epidemiology of avian haemoparasites: first, that nestlings in open nests have a higher prevalence of infection; and second, that nestlings sampled at 14 days old have a higher apparent infection rate than those sampled at 7 days old. Open-nesting individuals had a 54% infection rate compared with 25% for box-nesters, probably due to an increased exposure of open-nesting species to dipteran vectors. Nestlings sampled at 14 days had a 68% infection rate compared with 32% in nestlings sampled at 7 days, suggesting that rates of infection in the nest are high. Further work should examine nestlings post-fledging to identify rates of successful parasite infection (as opposed to abortive development within a dead-end host) as well as impacts on host post-fledging survival and behaviour

The protozoan parasite Trichomonas gallinae causes adult and nestling mortality in a declining population of European Turtle Doves, Streptopelia turtur

Studies incorporating the ecology of clinical and sub-clinical disease in wild populations of conservation concern are rare. Here we examine sub-clinical infection by Trichomonas gallinae in a declining population of free-living European Turtle Doves and suggest caseous lesions cause mortality in adults and nestlings through subsequent starvation and/or suffocation. We found a 100% infection rate by T. gallinae in adult and nestling Turtle Doves (n = 25) and observed clinical signs in three adults and four nestlings (28%). Adults with clinical signs displayed no differences in any skeletal measures of size but had a mean 3·7% reduction in wing length, with no overlap compared to those without clinical signs. We also identified T. gallinae as the suggested cause of mortality in one Red-legged Partridge although disease presentation was different. A minimum of four strains of T. gallinae, characterized at the ITS/5·8S/ITS2 ribosomal region, were isolated from Turtle Doves. However, all birds with clinical signs (Turtle Doves and the Red-legged Partridge) carried a single strain of T. gallinae, suggesting that parasite spill over between Columbidae and Galliformes is a possibility that should be further investigated. Overall, we highlight the importance of monitoring populations for sub-clinical infection rather than just clinical disease

Social support is associated with blood pressure responses in parents caring for children with developmental disabilities

peer-reviewedThe present study tested whether parents caring for children with developmental disabilities would have higher blood pressure compared to parents of typically developing children (controls). It also examined the psychosocial factors underlying this observation. Thirty-five parents of children with developmental disability and thirty controls completed standard measures of perceived stress, child challenging behaviours and social support and wore an ambulatory blood pressure (BP) monitor throughout the day, for one day. Relative to controls, parents caring for children with developmental disabilities reported poorer psychosocial functioning and had a higher mean systolic BP. Of, the psychosocial predictors, only social support was found to be predictive. Moreover, variations in social support accounted for some of the between group differences with the 13 for parental group attenuated from .42 to .34 in regression analyses. It appears that social support may influence blood pressure responses in parental caregivers. Finally, our findings underscore the importance of providing psychosocial interventions to improve the health of family caregivers. (C) 2012 Elsevier Ltd. All rights reserved.ACCEPTEDpeer-reviewe