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Osteogenic preconditioning in perfusion bioreactors improves vascularization and bone formation by human bone marrow aspirates.
Cell-derived extracellular matrix (ECM) provides a niche to promote osteogenic differentiation, cell adhesion, survival, and trophic factor secretion. To determine whether osteogenic preconditioning would improve the bone-forming potential of unfractionated bone marrow aspirate (BMA), we perfused cells on ECM-coated scaffolds to generate naïve and preconditioned constructs, respectively. The composition of cells selected from BMA was distinct on each scaffold. Naïve constructs exhibited robust proangiogenic potential in vitro, while preconditioned scaffolds contained more mesenchymal stem/stromal cells (MSCs) and endothelial cells (ECs) and exhibited an osteogenic phenotype. Upon implantation into an orthotopic calvarial defect, BMA-derived ECs were present in vessels in preconditioned implants, resulting in robust perfusion and greater vessel density over the first 14 days compared to naïve implants. After 10 weeks, human ECs and differentiated MSCs were detected in de novo tissues derived from naïve and preconditioned scaffolds. These results demonstrate that bioreactor-based preconditioning augments the bone-forming potential of BMA
Sliding mode control of a nonlinear wave energy converter model
The most accurate wave energy converter models for heaving point absorbers include nonlinearities, which increase as resonance is achieved to maximize the energy capture. Over the power production spectrum and within the physical limits of the devices, the efficiency of wave energy converters can be enhanced by employing a control scheme that accounts for these nonlinearities. This paper proposes a sliding mode control for a heaving point absorber that includes the nonlinear effects of the dynamic and static Froude‐Krylov forces. The sliding mode controller tracks a reference velocity that matches the phase of the excitation force to ensure higher energy absorption. This control algorithm is tested in regular linear waves and is compared to a complex‐conjugate control and a nonlinear variation of the complex‐conjugate control. The results show that the sliding mode control successfully tracks the reference and keeps the device displacement bounded while absorbing more energy than the other control strategies. Furthermore, due to the robustness of the control law, it can also accommodate disturbances and uncertainties in the dynamic model of the wave energy converter
MaaSim: A Liveability Simulation for Improving the Quality of Life in Cities
Urbanism is no longer planned on paper thanks to powerful models and 3D
simulation platforms. However, current work is not open to the public and lacks
an optimisation agent that could help in decision making. This paper describes
the creation of an open-source simulation based on an existing Dutch
liveability score with a built-in AI module. Features are selected using
feature engineering and Random Forests. Then, a modified scoring function is
built based on the former liveability classes. The score is predicted using
Random Forest for regression and achieved a recall of 0.83 with 10-fold
cross-validation. Afterwards, Exploratory Factor Analysis is applied to select
the actions present in the model. The resulting indicators are divided into 5
groups, and 12 actions are generated. The performance of four optimisation
algorithms is compared, namely NSGA-II, PAES, SPEA2 and eps-MOEA, on three
established criteria of quality: cardinality, the spread of the solutions,
spacing, and the resulting score and number of turns. Although all four
algorithms show different strengths, eps-MOEA is selected to be the most
suitable for this problem. Ultimately, the simulation incorporates the model
and the selected AI module in a GUI written in the Kivy framework for Python.
Tests performed on users show positive responses and encourage further
initiatives towards joining technology and public applications.Comment: 16 page
Ultraviolet Completion of Flavour Models
Effective Flavour Models do not address questions related to the nature of
the fundamental renormalisable theory at high energies. We study the
ultraviolet completion of Flavour Models, which in general has the advantage of
improving the predictivity of the effective models. In order to illustrate the
important features we provide minimal completions for two known A4 models. We
discuss the phenomenological implications of the explicit completions, such as
lepton flavour violating contributions that arise through the exchange of
messenger fields.Comment: 18 pages, 8 figure
Bridging flavour violation and leptogenesis in SU(3) family models
We reconsider basic, in the sense of minimal field content, Pati-Salam x
SU(3) family models which make use of the Type I see-saw mechanism to reproduce
the observed mixing and mass spectrum in the neutrino sector. The goal of this
is to achieve the observed baryon asymmetry through the thermal decay of the
lightest right-handed neutrino and at the same time to be consistent with the
expected experimental lepton flavour violation sensitivity. This kind of models
have been previously considered but it was not possible to achieve a
compatibility among all of the ingredients mentioned above. We describe then
how different SU(3) messengers, the heavy fields that decouple and produce the
right form of the Yukawa couplings together with the scalars breaking the SU(3)
symmetry, can lead to different Yukawa couplings. This in turn implies
different consequences for flavour violation couplings and conditions for
realizing the right amount of baryon asymmetry through the decay of the
lightest right-handed neutrino. Also a highlight of the present work is a new
fit of the Yukawa textures traditionally embedded in SU(3) family models.Comment: 26 pages, 5 figures, Some typos correcte
Fitting Neutrino Physics with a U(1)_R Lepton Number
We study neutrino physics in the context of a supersymmetric model where a
continuous R-symmetry is identified with the total Lepton Number and one
sneutrino can thus play the role of the down type Higgs. We show that
R-breaking effects communicated to the visible sector by Anomaly Mediation can
reproduce neutrino masses and mixing solely via radiative contributions,
without requiring any additional degree of freedom. In particular, a relatively
large reactor angle (as recently observed by the Daya Bay collaboration) can be
accommodated in ample regions of the parameter space. On the contrary, if the
R-breaking is communicated to the visible sector by gravitational effects at
the Planck scale, additional particles are necessary to accommodate neutrino
data.Comment: 19 pages, 3 figures; v2: references added, constraints updated,
overall conclusions unchange
On the nature of the fourth generation neutrino and its implications
We consider the neutrino sector of a Standard Model with four generations.
While the three light neutrinos can obtain their masses from a variety of
mechanisms with or without new neutral fermions, fourth-generation neutrinos
need at least one new relatively light right-handed neutrino. If lepton number
is not conserved this neutrino must have a Majorana mass term whose size
depends on the underlying mechanism for lepton number violation. Majorana
masses for the fourth generation neutrinos induce relative large two-loop
contributions to the light neutrino masses which could be even larger than the
cosmological bounds. This sets strong limits on the mass parameters and mixings
of the fourth generation neutrinos.Comment: To be published. Few typos corrected, references update
X-ray emission from isolated neutron stars
X-ray emission is a common feature of all varieties of isolated neutron stars
(INS) and, thanks to the advent of sensitive instruments with good
spectroscopic, timing, and imaging capabilities, X-ray observations have become
an essential tool in the study of these objects. Non-thermal X-rays from young,
energetic radio pulsars have been detected since the beginning of X-ray
astronomy, and the long-sought thermal emission from cooling neutron star's
surfaces can now be studied in detail in many pulsars spanning different ages,
magnetic fields, and, possibly, surface compositions. In addition, other
different manifestations of INS have been discovered with X-ray observations.
These new classes of high-energy sources, comprising the nearby X-ray Dim
Isolated Neutron Stars, the Central Compact Objects in supernova remnants, the
Anomalous X-ray Pulsars, and the Soft Gamma-ray Repeaters, now add up to
several tens of confirmed members, plus many candidates, and allow us to study
a variety of phenomena unobservable in "standard'' radio pulsars.Comment: Chapter to be published in the book of proceedings of the 1st Sant
Cugat Forum on Astrophysics, "ICREA Workshop on the high-energy emission from
pulsars and their systems", held in April, 201
Dynamical R-parity Breaking at the LHC
In a class of extensions of the minimal supersymmetric standard model with
(B-L)/left-right symmetry that explains the neutrino masses, breaking R-parity
symmetry is an essential and dynamical requirement for successful gauge
symmetry breaking. Two consequences of these models are: (i) a new kind of
R-parity breaking interaction that protects proton stability but adds new
contributions to neutrinoless double beta decay and (ii) an upper bound on the
extra gauge and parity symmetry breaking scale which is within the large hadron
collider (LHC) energy range. We point out that an important prediction of such
theories is a potentially large mixing between the right-handed charged lepton
() and the superpartner of the right-handed gauge boson (), which leads to a brand new class of R-parity violating interactions of
type and \widetilde{d^c}^\dagger\u^c
e^c. We analyze the relevant constraints on the sparticle mass spectrum and
the LHC signatures for the case with smuon/stau NLSP and gravitino LSP. We note
the "smoking gun" signals for such models to be lepton flavor/number violating
processes: (or ) and
(or ) without
significant missing energy. The predicted multi-lepton final states and the
flavor structure make the model be distinguishable even in the early running of
the LHC.Comment: 30 pages, 13 figures, 6 tables, reference adde
Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis
Background Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study’s objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine the role of GCA-specific characteristics on diagnostic delay. Methods Medical literature databases were searched from inception to November 2015. Articles were included if reporting a time-period of diagnostic delay between onset of GCA symptoms and diagnosis. Two reviewers assessed the quality of the final articles and extracted data from these. Random-effects meta-analysis was used to pool the mean time-period (95% confidence interval (CI)) between GCA symptom onset and diagnosis, and the delay observed for GCA-specific characteristics. Heterogeneity was assessed by I 2 and by 95% prediction interval (PI). Results Of 4128 articles initially identified, 16 provided data for meta-analysis. Mean diagnostic delay was 9.0 weeks (95% CI, 6.5 to 11.4) between symptom onset and GCA diagnosis (I 2 = 96.0%; P < 0.001; 95% PI, 0 to 19.2 weeks). Patients with a cranial presentation of GCA received a diagnosis after 7.7 (95% CI, 2.7 to 12.8) weeks (I 2 = 98.4%; P < 0.001; 95% PI, 0 to 27.6 weeks) and those with non-cranial GCA after 17.6 (95% CI, 9.7 to 25.5) weeks (I 2 = 96.6%; P < 0.001; 95% PI, 0 to 46.1 weeks). Conclusions The mean delay from symptom onset to GCA diagnosis was 9 weeks, or longer when cranial symptoms were absent. Our research provides an evidence-based benchmark for diagnostic delay of GCA and supports the need for improved public awareness and fast-track diagnostic pathways
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