644 research outputs found

    One-loop partition function of three-dimensional flat gravity

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    In this note we point out that the one-loop partition function of three-dimensional flat gravity, computed along the lines originally developed for the anti-de Sitter case, reproduces characters of the BMS3 group.Comment: 8 pages. v2: Minor misprints corrected, reference [10] updated. Published in JHE

    A 2D Field Theory Equivalent to 3D Gravity with No Cosmological Constant

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    info:eu-repo/semantics/publishe

    The Clustering of Extragalactic Extremely Red Objects

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    We have measured the angular and spatial clustering of 671 K5 Extremely Red Objects (EROs) from a 0.98 square degree sub-region of the NOAO Deep Wide-Field Survey (NDWFS). Our study covers nearly 5 times the area and has twice the sample size of any previous ERO clustering study. The wide field of view and BwRIK passbands of the NDWFS allow us to place improved constraints on the clustering of z=1 EROs. We find the angular clustering of EROs is slightly weaker than in previous measurements, and w(1')=0.25+/-0.05 for K<18.40 EROs. We find no significant correlation of ERO spatial clustering with redshift, apparent color or absolute magnitude, although given the uncertainties, such correlations remain plausible. We find the spatial clustering of K5 EROs is well approximated by a power-law, with r_0=9.7+/-1.1 Mpc/h in comoving coordinates. This is comparable to the clustering of 4L* early-type galaxies at z<1, and is consistent with the brightest EROs being the progenitors of the most massive ellipticals. There is evidence of the angular clustering of EROs decreasing with increasing apparent magnitude, when NDWFS measurements of ERO clustering are combined with those from the literature. Unless the redshift distribution of K>20 EROs is very broad, the spatial clustering of EROs decreases from r_0=9.7+/-1.1 Mpc/h for K20 EROs.Comment: Accepted for publication in the ApJ. 29 pages with 10 figures. The NOAO Deep Wide-Field Survey Bootes data release is available online at http://www.noao.edu/noao/noaodeep

    Hot topics, urgent priorities, and ensuring success for racial/ethnic minority young investigators in academic pediatrics.

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    BackgroundThe number of racial/ethnic minority children will exceed the number of white children in the USA by 2018. Although 38% of Americans are minorities, only 12% of pediatricians, 5% of medical-school faculty, and 3% of medical-school professors are minorities. Furthermore, only 5% of all R01 applications for National Institutes of Health grants are from African-American, Latino, and American Indian investigators. Prompted by the persistent lack of diversity in the pediatric and biomedical research workforces, the Academic Pediatric Association Research in Academic Pediatrics Initiative on Diversity (RAPID) was initiated in 2012. RAPID targets applicants who are members of an underrepresented minority group (URM), disabled, or from a socially, culturally, economically, or educationally disadvantaged background. The program, which consists of both a research project and career and leadership development activities, includes an annual career-development and leadership conference which is open to any resident, fellow, or junior faculty member from an URM, disabled, or disadvantaged background who is interested in a career in academic general pediatrics.MethodsAs part of the annual RAPID conference, a Hot Topic Session is held in which the young investigators spend several hours developing a list of hot topics on the most useful faculty and career-development issues. These hot topics are then posed in the form of six "burning questions" to the RAPID National Advisory Committee (comprised of accomplished, nationally recognized senior investigators who are seasoned mentors), the RAPID Director and Co-Director, and the keynote speaker.Results/conclusionsThe six compelling questions posed by the 10 young investigators-along with the responses of the senior conference leadership-provide a unique resource and "survival guide" for ensuring the academic success and optimal career development of young investigators in academic pediatrics from diverse backgrounds. A rich conversation ensued on the topics addressed, consisting of negotiating for protected research time, career trajectories as academic institutions move away from an emphasis on tenure-track positions, how "non-academic" products fit into career development, racism and discrimination in academic medicine and how to address them, coping with isolation as a minority faculty member, and how best to mentor the next generation of academic physicians

    Gastric Prolapse with Pseudocysts Following Laparoscopic Adjustable Gastric Banding

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    Nonpancreatic pseudocysts may be associated with gastric prolapse in patients who have undergone laparoscopic adjustable gastric banding

    Assessment of Child, Mother, and Environmental Factors Associated with Undernutrition in Children Less than Five Years Old in a Maya Community in Yucatan, Mexico

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    The objective of this study was to examine child, mother, and environmental factors associated with undernutrition in children less than five years old in a Maya community in Yucatan, Mexico. This investigation was designed as a case-control study. All cases (n=42) of undernutrition were included, and a sample of 52 controls was randomly selected from the study population. The frequency of investigated exposure factors was compared between cases and controls by using logistic regression. Undernutrition was associated with child’s age (&gt; 36 months old; OR = 3.53; 95% CI = 1.04, 18.40) and mother’s marital status (married; OR = 0.29; 95% CI = 0.09, 0.90). The odds of undernutrition were 2.81 times higher in children infected with Giardia spp, but this association was not significant (P = 0.18) after controlling for child’s age and mother’s marital status. In conclusion, child’s age and mother’s marital status were associated with child undernutrition in study subjects. Futures studies on undernutrition in children should examine more carefully how mother’s marital status alone or in combination with other factors (e.g. socio-economic, psychological factors) can influence child nutrition

    Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the international immuno-oncology biomarker working group on breast cancer.

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    Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high-throughput multiplex immunophenotyping of tumour samples has great potential to guide appropriate treatment choices. Moreover, the emergence of novel multi-marker imaging approaches can now provide unprecedented insights into the tumour microenvironment, including the potential interplay between various cell types. However, there are significant challenges to widespread integration of these technologies in daily research and clinical practice. This review addresses the challenges and potential solutions within a structured framework of action from a regulatory and clinical trial perspective. New developments within the field of immunophenotyping using multiplexed tissue imaging platforms and associated digital pathology are also described, with a specific focus on translational implications across different subtypes of cancer

    How accurate is the neurosurgery literature? A review of references.

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    BACKGROUND: The reference list is an important part of academic manuscripts. The goal of this study is to evaluate the reference accuracy in the field of neurosurgery. METHODS: This study examines four major peer-reviewed neurosurgery journals, chosen based on their clinical impact factor: Neurosurgery, J Neurosurg, World Neurosurg, and Acta Neurochir. For each of the four journals, five articles from each of the journal\u27s 12 issues published in 2019 were randomly selected using an online generator. This resulted in a total of 240 articles, 60 from each journal. Additionally, from each article\u27s list of references, one reference was again randomly selected and checked for a citation or quotation error. The chi-square test was used to analyze the association between the occurrence of citation and quotation errors and the presence of hypothesized risk factors that could impact reference accuracy. RESULTS: 62.1% of articles had a minor citation error, 8.33% had a major citation error, 12.1% had a minor quotation error, and 5.8% of articles had a major quotation error. Overall, Acta Neurochir presented with the fewest quotation errors compared with the other journals evaluated. The only association between the frequency of errors and potential markers of reference mistakes was with the length of the bibliography. Surprisingly, this correlation indicated that the articles with longer reference lists had fewer citation errors (p \u3c 0.01). Statistical significance was found between the occurrence of citation errors and the journals of publication (p \u3c 0.01). CONCLUSIONS: In order to advance medical treatment and patient care in neurosurgery, detailed documentation and attention to detail are necessary. The results from this analysis illustrate that improved reference accuracy is required

    Telemedicine for the Spine Surgeon in the Age of COVID-19: Multicenter Experiences of Feasibility and Implementation Strategies.

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    STUDY DESIGN: Multicenter study. OBJECTIVES: The COVID-19 pandemic has obligated physicians to recur to additional resources and make drastic changes regarding the standard physician-patient encounter. In the last century, there has been a substantial improvement in technology, which over the years has opened the door to a new form of medical practicing known as telemedicine. METHODS: Healthcare workers from three hospitals involved in the care for COVID-19 patients in the united states were invited to share their experience using telemedicine to deliver clinical care to their patients. RESULTS: Since the appearance of this worldwide outbreak, social distancing has been a key factor in preventing the spread of the virus, for which measures have been taken to limit physical contact. Because of the ongoing situation, telemedicine has been progressively incorporated into the physician-patient encounters and quickly has become an essential component in the day-today medical practice. CONCLUSIONS: It is feasible to deliver viable spine practice with the use of telemedicine. A proper patient selection of patients requiring virtual treatment versus those requiring in-person visits should be considered

    EXIT-chart aided hybrid multiuser detector design for frequency-domain-spread chip-interleaved MC-CDMA

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    With the advent of EXtrinsic Information Transfer (EXIT) charts, we are capable of analyzing, predicting and visually comparing the convergence behaviours of different turbo Multi-User Detectector (MUD)s. The different MUDs have diverse EXIT characteristics and hence their superposition allows us to create a combined EXIT curve, which closely matches that of the channel decoder. Hence a near-capacity operation is facilitated by combining the benifits of different MUDs and therefore to create a superior MUD. Thus in this contribution, we propose a novel hybrid MUD combining scheme, which combines the advantages of a high performance and low complexity in form of an advanced hybrid MUD solution. The transmitted bits are unknown at the receiver, hence it is not feasible to directly evaluate the mutual information gain of the iterative MUD in consecutive iterations, hence we propose a realistic algorithm for estimating this mutual information gain, which is then used for activating the most appropriate constituent MUD as and when it is necessary. The constituent MUDs are the Matched Filter (MF) based Soft Interference Cancellation (SoIC) and the optimum Bayesian MUDs, which are invoked in the scenario of Frequency-Domain-Spread Chip-Interleaved (FDSCI) Multiple Carrier Code Division Multiple Access (MC-CDMA). The resultant hybrid MUD is capable of outperforming both the MF-SoIC and Bayesian turbo MUDs in the terms of the attainable complexity and Bit-Error-Rate (BER) performance
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