Factores familiares que inciden en el rendimiento acad?mico de los estudiantes de la instituci?n educativa papagal?

175 p. Recurso Electr?nicoLa familia es la primera instituci?n educativa y es la base de toda sociedad. Es por eso que las din?micas familiares est?n ligadas al desarrollo y al aprendizaje de todos sus miembros y en especial de aquellos que se encuentran en una etapa de formaci?n escolar. Por esta raz?n a la hora de realizar estudios ligados a los factores que afectan el rendimiento acad?mico de los alumnos encontramos una relaci?n entre los aspectos socio-familiares y la escuela. El objetivo de esta investigaci?n es analizar el tipo de familia, el nivel educativo de los padres, la econom?a familiar, el clima familiar y otros aspectos familiares, y la forma en que dichos aspectos inciden en el rendimiento acad?micos de los estudiantes de la instituci?n educativa Papagal?, en el municipio de Salda?a, en el departamento del Tolima (Colombia). Palabras Claves: Educaci?n, familia, factores socio familiares, rendimiento acad?micoThe family is the first educational institution and is the basis of every society. That is why family dynamics are linked to the development and learning of all its members and especially those who are in a stage of school formation. For this reason when conducting studies related to the factors that affect the academic performance of students, we find a relationship between the socio-family aspects and the school. The objective of this research is to analyze the type of family, parents' educational level, family economy, family climate and other familiar aspects, and the way these aspects affect the academic performance of students of the Educational Institution Papagal?, in the municipality of Salda?a, in the department of Tolima (Colombia). Keywords: Education, family, socio-family factors, academic performanc

Ecuaciones diferenciales del c?lculo de variaciones

46 p. Recurso Electr?nic

La lectura como fortalecimiento de la autoestima.

71 p. Recurso Electr?nicoEl proyecto La lectura como fortalecimiento de la autoestima, busca que los ni?os y ni?as se acepten tal y como son, para que se vean menos afectados por los comentarios que haya hacia ellos, va dirigido principalmente a trabajar dentro del aula donde los ni?os y ni?as son m?s vulnerables a las opiniones de los dem?s. Hoy en d?a se hace necesario incentivarlos, para que crezcan con m?s confianza en s? mismos, y definan, de este modo, su personalidad. Al observarse en un espejo los estudiantes del grado tercero, les surgieron preguntas tales como: ?qui?n soy?, ?c?mo soy?, ?qu? siento?, ?c?mo me veo? Esto con el prop?sito de auto-conocerse y aceptarse, con defectos y cualidades; siempre debe importar el sentir emocional de cada uno, resaltando que se es valioso, para de este modo no ser ni hacer sentir inferior al otro; todos somos seres humanos con los mismos derechos y deberes. Por consiguiente, se escoge como m?todo la lectura de cuentos que hablen de la autoestima, que cuenten historias las cuales dejen una ense?anza, ya que es necesario ser aut?ntico, para de este modo lograr que los ni?os y ni?as del grado tercero de la Instituci?n Educativa Alfredo Garc?a reconozcan el valor de ser ?nicos y sentirse seguros. Por ?ltimo, se hizo un trabajo de resignificaci?n de valores como el respeto, la tolerancia y la solidaridad, entre muchos otros, para lograr una buena integraci?n y convivencia del ni?o y la ni?a con su entorno social y cultural.The project Reading as strengthening self-esteem, seeks that boys and girls are accepted as they are, so they will be less affected by the comments that there is for them, is primarily to work in the classroom where the children are more vulnerable to the opinions of others. Today it is necessary to encourage them to grow more confident in themselves, and, thus, to define his personality. To look in a mirror the third grade students emerged you questions such as: who am I? How am I? What I feel? How do I watch? This with the purpose of auto - get to know and accept, with defects and qualities; You should always import the emotional feel of each, highlighting that it is valuable, so not to be or make you feel inferior to another, we are all human beings with equal rights and duties. It is therefore selected as reading stories that talk about self-esteem, that tell stories which leave a teaching, it is necessary to be authentic, thus achieving children from the third grade of Alfredo Garcia educational institution to recognize the value of being unique and feel safe. Finally, a work of resignification of values such as respect, tolerance and solidarity, among many others, was done to achieve a successful integration and coexistence of the boy and the girl with their social and cultural environment. Keywords: personality, self-esteem, values, literature, acceptance

New Recurrent Structural Aberrations in the Genome of Chronic Lymphocytic Leukemia Based on Exome-Sequencing Data

Chronic lymphocytic leukemia (CLL) is the most frequent lymphoproliferative syndrome in Western countries, and it is characterized by recurrent large genomic rearrangements. During the last decades, array techniques have expanded our knowledge about CLL's karyotypic aberrations. The advent of large sequencing databases expanded our knowledge cancer genomics to an unprecedented resolution and enabled the detection of small-scale structural aberrations in the cancer genome. In this study, we have performed exome-sequencing-based copy number aberration (CNA) and loss of heterozygosity (LOH) analysis in order to detect new recurrent structural aberrations. We describe 54 recurrent focal CNAs enriched in cancer-related pathways, and their association with gene expression and clinical evolution. Furthermore, we discovered recurrent large copy number neutral LOH events affecting key driver genes, and we recapitulate most of the large CNAs that characterize the CLL genome. These results provide "proof-of-concept" evidence supporting the existence of new genes involved in the pathogenesis of CLL

Novel Mutation Hotspots within Non-Coding Regulatory Regions of the Chronic Lymphocytic Leukemia Genome

Mutations in non-coding DNA regions are increasingly recognized as cancer drivers. These mutations can modify gene expression in cis or by inducing high-order chormatin structure modifications with long-range effects. Previous analysis reported the detection of recurrent and functional non-coding DNA mutations in the chronic lymphocytic leukemia (CLL) genome, such as those in the 3' untranslated region of NOTCH1 and in the PAX5 super-enhancer. In this report, we used whole genome sequencing data produced by the International Cancer Genome Consortium in order to analyze regions with previously reported regulatory activity. This approach enabled the identification of numerous recurrently mutated regions that were frequently positioned in the proximity of genes involved in immune and oncogenic pathways. By correlating these mutations with expression of their nearest genes, we detected significant transcriptional changes in genes such as PHF2 and S1PR2. More research is needed to clarify the function of these mutations in CLL, particularly those found in intergenic regions

Expansion of different subpopulations of CD26 ?/low T cells in allergic and non-allergic asthmatics

CD26 displays variable levels between effector (TH17 >> TH1 > TH2 > Treg) and naive/memory (memory > naive) CD4(+) T lymphocytes. Besides, IL-6/IL(-)6R is associated with TH17-differentiation and asthma severity. Allergic/atopic asthma (AA) is dominated by TH2 responses, while TH17 immunity might either modulate the TH2-dependent inflammation in AA or be an important mechanism boosting non-allergic asthma (NAA). Therefore, in this work we have compared the expression of CD26 and CD126 (IL-6Ralpha) in lymphocytes from different groups of donors: allergic (AA) and non-allergic (NAA) asthma, rhinitis, and healthy subjects. For this purpose, flow cytometry, haematological/biochemical, and in vitro proliferation assays were performed. Our results show a strong CD26-CD126 correlation and an over-representation of CD26(-) subsets with a highly-differentiated effector phenotype in AA (CD4(+)CD26(-/low) T cells) and NAA (CD4(-)CD26(-) gammadelta-T cells). In addition, we found that circulating levels of CD26 (sCD26) were reduced in both AA and NAA, while loss of CD126 expression on different leukocytes correlated with higher disease severity. Finally, selective inhibition of CD26-mRNA translation led to enhanced T cell proliferation in vitro. These findings support that CD26 down-modulation could play a role in facilitating the expansion of highly-differentiated effector T cell subsets in asthma

Improved personalized survival prediction of patients with diffuse large B-cell Lymphoma using gene expression profiling

BACKGROUND: Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology has shed light on the clinical evolution of this pathology, leading to the discovery of prognostic factors based on gene expression data, genomic rearrangements and mutational subgroups. Nevertheless, additional efforts are needed in order to enable survival predictions at the patient level. In this study we investigated new machine learning-based models of survival using transcriptomic and clinical data. METHODS: Gene expression profiling (GEP) of in 2 different publicly available retrospective DLBCL cohorts were analyzed. Cox regression and unsupervised clustering were performed in order to identify probes associated with overall survival on the largest cohort. Random forests were created to model survival using combinations of GEP data, COO classification and clinical information. Cross-validation was used to compare model results in the training set, and Harrel's concordance index (c-index) was used to assess model's predictability. Results were validated in an independent test set. RESULTS: Two hundred thirty-three and sixty-four patients were included in the training and test set, respectively. Initially we derived and validated a 4-gene expression clusterization that was independently associated with lower survival in 20% of patients. This pattern included the following genes: TNFRSF9, BIRC3, BCL2L1 and G3BP2. Thereafter, we applied machine-learning models to predict survival. A set of 102 genes was highly predictive of disease outcome, outperforming available clinical information and COO classification. The final best model integrated clinical information, COO classification, 4-gene-based clusterization and the expression levels of 50 individual genes (training set c-index, 0.8404, test set c-index, 0.7942). CONCLUSION: Our results indicate that DLBCL survival models based on the application of machine learning algorithms to gene expression and clinical data can largely outperform other important prognostic variables such as disease stage and COO. Head-to-head comparisons with other risk stratification models are needed to compare its usefulness

LipoDDx: a mobile application for identification of rare lipodystrophy syndromes

BACKGROUND: Lipodystrophy syndromes are a group of disorders characterized by a loss of adipose tissue once other situations of nutritional deprivation or exacerbated catabolism have been ruled out. With the exception of the HIV-associated lipodystrophy, they have a very low prevalence, which together with their large phenotypic heterogeneity makes their identification difficult, even for endocrinologists and pediatricians. This leads to significant delays in diagnosis or even to misdiagnosis. Our group has developed an algorithm that identifies the more than 40 rare lipodystrophy subtypes described to date. This algorithm has been implemented in a free mobile application, LipoDDx(R). Our aim was to establish the effectiveness of LipoDDx(R). Forty clinical records of patients with a diagnosis of certainty of most lipodystrophy subtypes were analyzed, including subjects without lipodystrophy. The medical records, blinded for diagnosis, were evaluated by 13 physicians, 1 biochemist and 1 dentist. Each evaluator first gave his/her results based on his/her own criteria. Then, a second diagnosis was given using LipoDDx(R). The results were analysed based on a score table according to the complexity of each case and the prevalence of the disease. RESULTS: LipoDDx(R) provides a user-friendly environment, based on usually dichotomous questions or choice of clinical signs from drop-down menus. The final result provided by this app for a particular case can be a low/high probability of suffering a particular lipodystrophy subtype. Without using LipoDDx(R) the success rate was 17 +/- 20%, while with LipoDDx(R) the success rate was 79 +/- 20% (p < 0.01). CONCLUSIONS: LipoDDx(R) is a free app that enables the identification of subtypes of rare lipodystrophies, which in this small cohort has around 80% effectiveness, which will be of help to doctors who are not experts in this field. However, it will be necessary to analyze more cases in order to obtain a more accurate efficiency value

Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial

Background: Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. The primary study aim is to compare the rates of clinical remission at 1?year in patients who discontinue anti-TNF treatment versus those who continue treatment. Methods: This is an ongoing, prospective, double-blind, multicentre, randomized, placebo-controlled study in patients with Crohn?s disease or ulcerative colitis who have achieved clinical remission for ?6?months with an anti-TNF treatment and an immunosuppressant. Patients are being randomized 1:1 to discontinue anti-TNF therapy or continue therapy. Randomization stratifies patients by the type of inflammatory bowel disease and drug (infliximab versus adalimumab) at study inclusion. The primary endpoint of the study is sustained clinical remission at 1?year. Other endpoints include endoscopic and radiological activity, patient-reported outcomes (quality of life, work productivity), safety and predictive factors for relapse. The required sample size is 194 patients. In addition to the main analysis (discontinuation versus continuation), subanalyses will include stratification by type of inflammatory bowel disease, phenotype and previous treatment. Biological samples will be obtained to identify factors predictive of relapse after treatment withdrawal. Results: Enrolment began in 2016, and the study is expected to end in 2020. Conclusions: This study will contribute prospective, controlled data on outcomes and predictors of relapse in patients with inflammatory bowel disease after withdrawal of anti-TNF agents following achievement of clinical remission. Clinical trial reference number: EudraCT 2015-001410-1