Incorporación de herramientas de evaluación orientada al aprendizaje para actividades no presenciales en plataformas de apoyo virtual a la docencia

Memoria ID-0263. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

Situaciones académicas que provocan mayor estrés en el estudiante universitario de grado

Memoria ID-033. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2013-2014

A Blended Learning Experience in Statistics for Psychology Students Using the Evaluation as a Learning Tool

Teaching statistics course Applied Psychology, was based on different teaching models that incorporate active teaching methodologies. In this experience have combined approaches that prioritize the use of ICT with other where evaluation becomes an element of learning. This has involved the use of virtual platforms to support teaching that facilitate learning and activities where no face-to-face are combined. The design of the components of the course is inspired by the dimensions proposed by Carless (2003) model. This model uses evaluation as a learning element. The development of this experience has shown how the didactic proposal has been positively interpreted by students. Students recognized that they had to learn and deeply understand the basic concepts of the subject, so that they can teach and assess their peers.La enseñanza de la asignatura de Estadística Aplicada a la Psicología, se ha basado en diferentes modelos didácticos que incorporan metodologías activas de enseñanza. En esta experiencia se han combinado enfoques que priorizan el uso de las TIC con otros donde la evaluación se convierte en un elemento de aprendizaje. Ello ha supuesto la utilización de plataformas de apoyo virtual a la docencia que posibilitan un aprendizaje donde se combinan actividades presenciales y no presenciales. El diseño de los componentes del curso está inspirado en las dimensiones del modelo propuesto por Carless (2003). Este modelo utiliza la evaluación como elemento de aprendizaje. El desarrollo de esta experiencia ha mostrado cómo la propuesta didáctica ha sido interpretada positivamente por los estudiantes. Los alumnos reconocieron que tenían que aprender y comprender en profundidad los conceptos básicos de la asignatura, para que ellos puedan enseñar y evaluar a sus compañeros

A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK

[EN] Connexin43 (CX43), a protein that forms gap junction channels and hemichannels in astrocytes, is downregulated in high-grade gliomas. Its relevance for glioma therapy has been thoroughly explored; however, its positive effects on proliferation are counterbalanced by its effects onmigration and invasion. Here,weshowthat a cell-penetrating peptide based onCX43(TAT-Cx43266-283) inhibited c-Src and focal adhesion kinase (FAK) and upregulated phosphatase and tensinhomolog inglioma stem cells (GSCs) derived from patients. Consequently, TAT-Cx43266-283 reduced GSC motility, as analyzed by time-lapse microscopy, and strongly reduced their invasive ability. Interestingly, we investigated the effects of TAT-Cx43266-283 on freshly removed surgical specimens as undissociated glioblastoma blocks, which revealed a dramatic reduction in the growth, migration, and survival of these cells. In conclusion, a region of CX43 (amino acids 266–283) exerts an important anti-tumor effect in patient-derived glioblastoma models that includes impairment of GSC migration and invasion

El papel de la autoestima y el apego entre iguales en grupos de trabajo bajo entornos de apoyo virtual a la docencia

Memoria ID-0004. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2017-2018

¿El entusiasmo mostrado por el docente favorece el recuerdo y comprensión de los contenidos expuestos y la motivación intrínseca de los estudiantes?

Memoria ID-0108. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2016-2017

Diseño y desarrollo de un simulador del entorno de cruce peatonal. Desde la evaluación mediante la captura de movimiento hacia su posible uso como entorno de entrenamiento

[ES]Los hallazgos encontrados por la psicología experimental relacionados con la marcha en las personas mayores y los riesgos de caídas y su prevención, no se han generalizado de forma sistemática al contexto de seguridad vial y por lo tanto no se han incorporado suficientemente a la investigación del comportamiento peatonal. Los estudios que unen las dos perspectivas son escasos, además de no reunir el rigor de medida y el control de variables que caracterizan a los estudios experimentales frente a los observacionales. Incorporar el paradigma de la doble tarea, propio del contexto experimental, al ámbito de la seguridad vial de las personas mayores, es el objetivo del trabajo. Además, pretendemos verificar el papel de la experiencia previa como conductores y del conocimiento de la normativa de tráfico en los protocolos educativos. Intentaremos conseguirlo mediante la creación de un simulador de cruce peatonal en todas sus condiciones (con semáforo y sin semáforo). En definitiva, se trata de establecer si el efecto de estímulos, tanto relacionados con el tráfico como no, interfiere de manera diferente en la conducta motora de cruce de calzada, dependiendo de la experiencia previa como conductores que tengan las personas.Dirección General de Tráfic

Tumor cell and immune cell profiles in primary human glioblastoma: Impact on patient outcome

© 2020 The Authors.The distribution and role of tumor-infiltrating leucocytes in glioblastoma (GBM) remain largely unknown. Here, we investigated the cellular composition of 55 primary (adult) GBM samples by flow cytometry and correlated the tumor immune profile with patient features at diagnosis and outcome. GBM single-cell suspensions were stained at diagnosis (n = 44) and recurrence following radiotherapy and chemotherapy (n = 11) with a panel of 8-color monoclonal antibody combinations for the identification and enumeration of (GFAPCD45) tumor and normal astrocytic cells, infiltrating myeloid cells —i.e. microglial and blood-derived tumor-associated macrophages (TAM), M1-like, and M2-like TAM, neutrophils. and myeloid-derived suppressor cells (MDSC)— and tumor-infiltrating lymphocytes (TIL) —i.e. CD3T-cells and their TCD4, TCD8, TCD4CD8, and (CD25CD127) regulatory (T-regs) subsets, (CD19CD20) B-cells, and (CD16) NK-cells—. Overall, GBM samples consisted of a major population (mean ± 1SD) of tumor and normal astrocytic cells (73% ± 16%) together with a significant but variable fraction of immune cells (24% ± 18%). Within myeloid cells, TAM predominated (13% ± 12%) including both microglial cells (10% ± 11%) and blood-derived macrophages (3% ± 5%), in addition to a smaller proportion of neutrophils (5% ± 9%) and MDSC (4% ± 8%). Lymphocytes were less represented and mostly included TCD4 (0.5% ± 0.7%) and TCD8 cells (0.6% ± 0.7%), together with lower numbers of TCD4CD8 T-cells (0.2% ± 0.4%), T-regs (0.1% ± 0.2%), B-lymphocytes (0.1% ± 0.2%) and NK-cells (0.05% ± 0.05%). Overall, three distinct immune profiles were identified: cases with a minor fraction of leucocytes, tumors with a predominance of TAM and neutrophils, and cases with mixed infiltration by TAM, neutrophils, and T-lymphocytes. Untreated GBM patients with mixed myeloid and lymphoid immune infiltrates showed a significantly shorter patient overall survival versus the other two groups, in the absence of gains of the EGFR gene (p = 0.02). Here we show that immune cell infiltrates are systematically present in GBM, with highly variable levels and immune profiles. Patients with mixed myeloid and T-lymphoid infiltrates showed a worse outcome.Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Madrid, Spain and fondos FEDER, Grant/Award Number: CB16/12/00400 and ISCIII PI16/0476; Consejería de Sanidad Junta de Castilla y León, Gerencia Regional de Salud, Spain, Grant/Award Number: GRS2049/A/1

Prognostic stratification of adult primary glioblastoma multiforme patients based on their tumor gene amplification profiles

Several classification systems have been proposed to address genomic heterogeneity of glioblastoma multiforme, but they either showed limited prognostic value and/or are difficult to implement in routine diagnostics. Here we propose a prognostic stratification model for these primary tumors based on tumor gene amplification profiles, that might be easily implemented in routine diagnostics, and potentially improve the patients management. Gene amplification profiles were prospectively evaluated in 80 primary glioblastoma multiforme tumors using singlenucleotide polymorphism arrays and the results obtained validated in publicly available data from 267/347 cases. Gene amplification was detected in 45% of pati

Procesos de regulación consciente y no-consciente del rendimiento académico de estudiantes universitarios en un entorno educativo virtual

Memoria ID-0191. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2017-2018