ETAA1 ensures proper chromosome segregation: A matter of S phase or mitosis?

ETAA1 activates the master checkpoint kinase ATR. Bass and Cortez (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810058) recently reported an intra-mitotic function of ETAA1 that safeguards chromosome stability. In this issue, Achuthankutty et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201905064) describe a mechanism controlling the ATR-activating potential of ETAA1 in S phase to preserve chromosome stability.Fil: González, Marina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentin

Estenosis aórtica severa en la vida real. Determinantes del manejo y pronóstico

La estenosis aórtica (EAo) es la enfermedad valvular cardíaca más común en los países desarrollados y tiene un mal pronóstico cuando aparecen los síntomas. Según las guías de práctica clínica la sustitución valvular aórtica (SVAo) es el tratamiento de elección para la EAo severa sintomática. La implantación de válvula aórtica transcatéter (TAVI), presenta buenos resultados a corto y mediano plazo de seguimiento, por lo que cada vez más juega un papel preponderante como opción de tratamiento en los pacientes con EAo severa sintomática. A pesar de las opciones actuales, muchos de los pacientes con EAo severa sintomática son manejados con medicamentos. Nuestro objetivo fue evaluar los determinantes en el manejo y pronóstico de la EAo severa en la vida real. Métodos: Registro multicéntrico (en 48 centros españoles) que incluyó a todos los adultos con EAo severa (gradiente medio≥40 mmHg o área valvular aórtica (AVA) <1 cm2 estimada por ecuación de continuidad, sin intervención valvular previa) diagnosticados por ecocardiograma transtorácico durante el mes de enero de 2014. Se registraron las características clínicas, datos ecocardiográficos, índice de comorbilidad de Charlson, así como el European System for Cardiac Operative Risk Evaluation (EuroSCORE-II). Se realizó seguimiento clínico mediante revisión de historias clínicas o contacto telefónico a los 12 meses en todos los pacientes, incluyendo estado vital y realización de intervención valvular (quirúrgica o percutánea). Se consideraron muertes de causa cardíaca las debidas a insuficiencia cardíaca, muerte súbita o infarto de miocardio..

Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management

Worldwide, more than 1.9 billion adults are overweight, and around 600 million people suffer from obesity. Similarly, *382 million individuals live with diabetes, and 40–50% of the global population is labeled at ‘‘high risk’’ (i.e., prediabetes). The impact of these two chronic conditions relies not only on the burden of illnesses per se (i.e., associated increased morbidity and mortality), but also on their increased cost, burden of treatment, and decreased health-related quality of life. For this review a comprehensive search in several databases including PubMed (MEDLINE), Ovid EMBASE, Web of Science, and Scopus was conducted. In both diabetes and obesity, genetic, epigenetic, and environmental factors overlap and are inclusive rather than exclusive

Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study

Background. Although the association between human chorionic gonadotropin (hCG) and hyperandrogenism was identified more than 40 years ago, relevant questions remain unanswered. Design and Methods. We conducted a prospective, longitudinal, and controlled study in 23 women with a diagnosis of a complete hydatidiform mole (HM). Results. All participants completed the study. Before HM evacuation mean hCG was markedly higher in the cases than in the control group (P≤0.001). Free testosterone (T) and dehydroepiandrosterone sulfate (DHEA-S) were found to be higher in the cases (2.78 ± 1.24 pg/mL and 231.50 ± 127.20 μ/dL) when compared to the control group (1.50 ± 0.75 pg/mL and 133.59 ± 60.69 μ/dL) (P=0.0001 and 0.001), respectively. There was a strong correlation between hCG and free T/total T/DHEA-S concentrations (r=0.78; P≤0.001, r=0.74;  P≤0.001, and r=0.71;  P≤0.001), respectively. In the cases group 48 hours after HM evacuation, hCG levels were found to be significantly lower when compared to initial levels (P=0.001) and free T and DHEA-S declined significantly (P=0.0002 and 0.009). Conclusion. Before uterus evacuation, hCG, free T, and DHEA-S levels were significantly higher when compared with controls finding a strong correlation between hCG and free T/DHEA-S levels. Forty-eight hours after HM treatment hCG levels declined and the difference was lost. A novel finding of our study is that in cases, besides free T, DHEA-S was also found to be significantly higher and both the ovaries and adrenal glands appear to be the sites of this androgen overproduction

Correlation between obesity and severity of distal radius fractures

Introduction: The incidence of obesity has increased significantly worldwide. Our hypothesis was that patients with obesity have a more severe distal radius fracture and we realized a study to evaluate this correlation between obesity and severity of distal radius fractures caused by low-energy injuries. Materials and methods: A total of 114 patients with distal radius fracture were examined in

Identificación de Requisitos Legales Ambientales en una Empresa de Manufactura en Matamoros, Tamaulipas

The main objective of this article is to identify the environmental legal requirements of a rubber hose manufacturing company, in the city of H. Matamoros, Tamaulipas; through a bibliographic review of current environmental legislation in its three types of jurisdictions: federal, state, and local. Having the requirements identified, a matrix of legal requirements is created (own creation) that allows planning compliance with them, being in accordance with the competent authorities, avoiding sanctions or fines and most importantly: controlling and reducing pollution of the productive processes.El objetivo principal del presente artículo es identificar los requisitos legales ambientales de una empresa de manufactura de mangueras de hule, en la ciudad de H. Matamoros, Tamaulipas; mediante la revisión bibliográfica la legislación ambiental vigente en sus tres tipos de competencia: federal, estatal y local. Al tener los requisitos identificados se constituye una matriz de requisitos legales (creación propia) que permite realizar la planeación del cumplimiento de los mismos, estando en concordancia con las autoridades competentes, evitando sanciones o multas y lo más importante: controlar y disminuir la contaminación de los procesos productivos

Selección de productos antivirus. Una mirada actual desde el sector de la salud en Cuba

La selección del antivirus en ocasiones puede resultar un trabajo un poco tedioso debido a la gran gama de variedades que existe en el mercado. El presente trabajo brindó una panorámica actual a los principales antivirus utilizados en el sistema de salud cubano. Se utilizaron diferentes métodos teóricos y empíricos como el histórico lógico, análisis y síntesis y la observación para extraer y sintetizar los elementos principales de la bibliografía citada. Se brindaron pautas y recomendaciones generales que pueden ser tenidas en cuenta antes de seleccionar un producto antivirus específico. Se planteó que la selección del mejor antivirus dependerá de las condiciones técnicas donde se ejecute, de su autorización en el sector de la salud y de las preferencias que posea el usuario final.Palabras claves: virus informáticos, antivirus, comparación de antivirus, mejor antivirus.</p

New stable by construction autonomous aerial vehicle: configuration and dynamic model.

[ES] En los últimos años, diferentes estrategias y modelos matemáticos se han desarrollado para el análisis y control de vehículos aéreos no tripulados. El presente artículo amplía este panorama al enfocarse en un sistema aéreo no tripulado estable por construcción. Gracias a su diseño, el sistema reportado disipa la energía que recibe por la acción de perturbaciones externas. El sistema propuesto cuenta con un rotor único para el desarrollo de diferentes tipos de vuelo. Este artículo reporta el concepto de diseño del sistema aéreo no tripulado, la estructura de su modelo dinámico de nueve grados de libertad, un conjunto de simulaciones numéricas que permiten analizar el comportamiento del modelo desarrollado y los primeros resultados experimentales que validan la estabilidad por construcción del vehículo aéreo autónomo. Los dos aspectos más significativos e innovadores reportados en este artículo son el uso de un rotor único orientable para la ejecución de diferentes modos de vuelo y la propiedad inherente del sistema tal que sus estructuras, externa e interna, son estables por construcción.[EN] In recent years, different strategies and mathematical models have been developed in order to analyze and control unmanned aerial vehicles. This article expands this panorama by focusing on a, stable by construction, unmanned aerial system. Thanks to its design, the reported system dissipates the energy received by the action of external disturbances. The proposed vehicle has a unique rotor in order to perform different flight modes. This article reports the design concept of the aerial system, the mathematical structure of its nine degrees of freedom dynamic model, a set of numerical simulations allowing the analysis of the behavior of the developed model and the first experimental results that validate the stability, by construction, of the aerial vehicle. The two most significant and innovative aspects reported in this article are the use of a single orientable rotor to perform different flight modes and the inherent property of the system that makes it stable by construction.Este trabajo fue apoyado por la Universidad Autónoma del Estado de México bajo el proyecto de investigación: Desarrollo de un Vehículo Esférico Aéreo Autónomo con clave 3818/2014/CIB. Eduardo Sánchez Fontes agradece el financiamiento por la beca CONACYT CVU 553663.Sánchez-Fontes, E.; Avila Vilchis, JC.; Vilchis-González, AH.; Saldivar, B.; Jacinto-Villegas, JM.; Martínez-Mendez, R. (2020). Nuevo vehículo aéreo autónomo estable por construcción: configuración y modelo dinámico. Revista Iberoamericana de Automática e Informática industrial. 17(3). https://doi.org/10.4995/riai.2020.11603OJS275173Apkarian, J., Sep. 2010. Aerial vehicle. Patent US 2010/0224723 A1, Bereskin and Parr LLP/S.E.N.C.R.L., s.r.l. 40 King Street West, Box 401 Toronto, onM5H 3Y2.Austin, R., 2010. Unmanned Aircraft Systems: UAVs Design, Development and Deployment. AIAA education series. American Institute of Aeronautics and Astronautics. https://doi.org/10.1002/9780470664797Avila Vilchis, J. C., Sanchez-Fontes, E., Vilchis González, A. H., Saldivar, B., Martinez-Mendez, R., 2018. Dispositivo aéreo de rotor único. Patent application MX/a/2018/012344, Universidad Autónoma del Estado de México, México.Briod, A., Klaptocz, A., Zu_erey, J. C., Floreano, D., Jul. 2012. The airburr: A flying robot that can exploit collisions. 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Modelling and control of a convertible VTOL aircraft. In: Proceedings of the 45th IEEE Conference on Decision and Control. pp. 69-74. https://doi.org/10.1109/CDC.2006.376915Escareño, J., Sanchez, A., Garcia, O., Lozano, R., 2008b. Triple tilting rotor mini-uav: Modeling and embedded control of the attitude. In: American Control Conference. pp. 3476-3481. https://doi.org/10.1109/ACC.2008.4587031Flores, G., Lozano, R., 2013. Transition flight control of the quad-tilting rotor convertible mav. In: International Conference on Unmanned Aircraft Systems (ICUAS). pp. 789-794. https://doi.org/10.1109/ICUAS.2013.6564761Garcia, P., Lozano, R., Dzul, A., 2006. Modelling and control of mini-flying machines. Vol. 48. Springer London. https://doi.org/10.1109/taes.2012.6324687Jacinto-Villegas, J. M., Satler, M., Filippeschi, A., Bergamasco, M., Ragaglia, M., Argiolas, A., Niccolini, M., Avizzano, C. A., Oct. 2017. A novel wearable haptic controller for teleoperating robotic platforms. 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Baseline ECG and prognosis after transcatheter aortic valve implantation: the role of interatrial block

Background: The clinical significance of conduction disturbances after transcatheter aortic valve implantation has been described; however, little is known about the influence of baseline ECGs in the prognosis of these patients. Our aim was to study the influence of baseline ECG parameters, including interatrial block (IAB), in the prognosis of patients treated with transcatheter aortic valve implantation. Methods and Results: The BIT (Baseline Interatrial Block and Transcatheter Aortic Valve Implantation) registry included 2527 patients with aortic stenosis treated with transcatheter aortic valve implantation. A centralized analysis of baseline ECGs was performed. Patients were divided into 4 groups: normal P wave duration (<120 ms); partial IAB (P wave duration ≥120 ms, positive in the inferior leads); advanced IAB (P wave duration ≥120 ms, biphasic [+/-] morphology in the inferior leads); and nonsinus rhythm (atrial fibrillation/flutter and paced rhythm). The mean age of patients was 82.6±9.8 years and 1397 (55.3%) were women. A total of 960 patients (38.0%) had a normal P wave, 582 (23.0%) had partial IAB, 300 (11.9%) had advanced IAB, and 685 (27.1%) presented with nonsinus rhythm. Mean follow‐up duration was 465±171 days. Advanced IAB was the only independent predictor of all‐cause mortality (hazard ratio [HR], 1.48; 95% CI, 1.10-1.98 [P=0.010]) and of the composite end point (death/stroke/new atrial fibrillation) (HR, 1.51; 95% CI, 1.17-1.94 [P=0.001]). Conclusions: Baseline ECG characteristics influence the prognosis of patients with aortic stenosis treated with transcatheter aortic valve implantation. Advanced IAB is present in about an eighth of patients and is associated with all‐cause death and the composite end point of death, stroke, and new atrial fibrillation during follow‐up