2,882 research outputs found
Pseudoartrosis de húmero en la enfermedad de Paget: presentación de un caso
Presentamos un paciente diagnosticado de enfermedad de Paget que sufrió
una fractura patológica del húmero. El tratamiento ortopédico de la fractura deparó una
pseudoartrosis. El resultado del tratamiento quirúrgico de ésta fue bueno. Se discute la
incidencia de la afectación del húmero en la enfermedad de Paget y aspectos relativos a
la curación de las fracturas del mismo.A patient with Paget's disease who had a pathological fracture of the humerus
was presented. The fracture was orthopedically treated and developed non-union.
Good result was achieved with surgical treatment. Incidence of Paget's disease on the humerus
and healing in these fractures are discussed
Storage under combined ultraviolet (UV) and light-emitting diodes (LED) enhances carotenoid concentration in mature green tomatoes
Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation
Fruit and vegetable consumption is associated at the population level with a protective effect against colorectal cancer. Phenolic compounds, especially abundant in berries, are of interest due to their putative anticancer activity. After consumption, however, phenolic compounds are subject to digestive conditions within the gastrointestinal tract that alter their structures and potentially their function. However, the majority of phenolic compounds are not efficiently absorbed in the small intestine and a substantial portion pass into the colon. We characterized berry extracts (raspberries, strawberries, blackcurrants) produced by in vitro-simulated upper intestinal tract digestion and subsequent fecal fermentation. These extracts and selected individual colonic metabolites were then evaluated for their putative anticancer activities using in vitro models of colorectal cancer, representing the key stages of initiation, promotion and invasion. Over a physiologically-relevant dose range (0–50 µg/ml gallic acid equivalents), the digested and fermented extracts demonstrated significant anti-genotoxic, anti-mutagenic and anti-invasive activity on colonocytes. This work indicates that phenolic compounds from berries undergo considerable structural modifications during their passage through the gastrointestinal tract but their breakdown products and metabolites retain biological activity and can modulate cellular processes associated with colon cancer
Electronic structure of reconstructed Au(100): Two-dimensional and one-dimensional surface states
Molecular profiling of immunoglobulin heavy-chain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients
Altres ajuts: This work was partially supported by[...] , CIBERONC-CB16/12/00233, and "Una manera de hacer Europa" (Innocampus; CEI-2010-1-0010)". M.G.-A., I.P.-C., and C.J. are supported by the Fundación Española de Hematología y Hemoterapia (FEHH, co-funded by Fundación Cris in the latter case), A.M. by the European Social Fund and the Spanish Education Council through the University of Salamanca, [...]. All Spanish funding is co-sponsored by the European Union FEDER program.Multiple myeloma is a heterogeneous disease whose pathogenesis has not been completely elucidated. Although B-cell receptors play a crucial role in myeloma pathogenesis, the impact of clonal immunoglobulin heavy-chain features in the outcome has not been extensively explored. Here we present the characterization of complete heavy-chain gene rearrangements in 413 myeloma patients treated in Spanish trials, including 113 patients characterized by next-generation sequencing. Compared to the normal B-cell repertoire, gene selection was biased in myeloma, with significant overrepresentation of IGHV3, IGHD2 and IGHD3, as well as IGHJ4 gene groups. Hypermutation was high in our patients (median: 8.8%). Interestingly, regarding patients who are not candidates for transplantation, a high hypermutation rate (≥7%) and the use of IGHD2 and IGHD3 groups were associated with improved prognostic features and longer survival rates in the univariate analyses. Multivariate analysis revealed prolonged progression-free survival rates for patients using IGHD2/IGHD3 groups (HR: 0.552, 95% CI: 0.361−0.845, p = 0.006), as well as prolonged overall survival rates for patients with hypermutation ≥7% (HR: 0.291, 95% CI: 0.137−0.618, p = 0.001). Our results provide new insights into the molecular characterization of multiple myeloma, highlighting the need to evaluate some of these clonal rearrangement characteristics as new potential prognostic markers
Retrieval of aerosol properties from zenith sky radiance measurements
This study explores the potential to retrieve aerosol properties
with the GRASP algorithm (Generalized Retrieval of Atmosphere and Surface
Properties) using as input measurements of zenith sky radiance (ZSR), which
are sky radiance values measured in the zenith direction, recorded at four
wavelengths by a ZEN-R52 radiometer. To this end, the ZSR measured at 440,
500, 675 and 870 nm by a ZEN-R52 (ZSRZEN), installed in Valladolid
(Spain), is employed. This instrument is calibrated by intercomparing the
signal of each channel with coincident ZSR values simulated (ZSRSIM) at
the same wavelengths with a radiative transfer model (RTM). These
simulations are carried out using the GRASP forward module as RTM and the
aerosol information from a co-located CE318 photometer belonging to
AERONET (AErosol RObotic NETwork) as input. The dark signal and the
signal dependence on temperature are characterized and included in the
calibration process. The uncertainties for each channel are quantified by an
intercomparison with a co-located CE318 photometer, obtaining lower values
for shorter wavelengths; they are between 3 % for 440 nm and 21 % for 870 nm. The
proposed inversion strategy for the aerosol retrieval using the ZSRZEN
measurements as input, i.e. so-called GRASP-ZEN, assumes the aerosol as an
external mixture of five pre-calculated aerosol types. A sensitivity
analysis is conducted using synthetic ZSRZEN measurements, pointing out
that these measurements are sensitive to aerosol load and type. It also
assesses that the retrieved aerosol optical depth (AOD) values in general
overestimate the reference ones by 0.03, 0.02, 0.02 and 0.01 for 440, 500,
675 and 870 nm, respectively. The calibrated ZSRZEN measurements, recorded
during 2.5 years at Valladolid, are inverted by the GRASP-ZEN strategy
to retrieve some aerosol properties like AOD. The retrieved AOD shows a high
correlation with respect to independent values obtained from a co-located
AERONET CE318 photometer, with determination coefficients (r2) of
0.86, 0.85, 0.79 and 0.72 for 440, 500, 675 and 870 nm, respectively, and
finding uncertainties between 0.02 and 0.03 with respect to the AERONET
values. Finally, the retrieval of other aerosol properties, like aerosol
volume concentration for total, fine and coarse modes (VCT, VCF and VCC, respectively), is
also explored. The comparison against independent values from AERONET
presents r2 values of 0.57, 0.56 and 0.66 and uncertainties of 0.009,
0.016 and 0.02 µm3 µm−2 for VCT, VCF and VCC, respectively.</p
Bound-state energies in argon trimers via a variational expansion: The effects from many-body corrections
Measurement of the Crab Nebula spectrum over three decades in energy with the MAGIC telescopes
The MAGIC stereoscopic system collected 69 hours of Crab Nebula data between
October 2009 and April 2011. Analysis of this data sample using the latest
improvements in the MAGIC stereoscopic software provided an unprecedented
precision of spectral and night-by-night light curve determination at gamma
rays. We derived a differential spectrum with a single instrument from 50 GeV
up to almost 30 TeV with 5 bins per energy decade. At low energies, MAGIC
results, combined with Fermi-LAT data, show a flat and broad Inverse Compton
peak. The overall fit to the data between 1 GeV and 30 TeV is not well
described by a log-parabola function. We find that a modified log-parabola
function with an exponent of 2.5 instead of 2 provides a good description of
the data (). Using systematic uncertainties of red the MAGIC and
Fermi-LAT measurements we determine the position of the Inverse Compton peak to
be at (53 3stat + 31syst -13syst) GeV, which is the most precise
estimation up to date and is dominated by the systematic effects. There is no
hint of the integral flux variability on daily scales at energies above 300 GeV
when systematic uncertainties are included in the flux measurement. We consider
three state- of-the-art theoretical models to describe the overall spectral
energy distribution of the Crab Nebula. The constant B-field model cannot
satisfactorily reproduce the VHE spectral measurements presented in this work,
having particular difficulty reproducing the broadness of the observed IC peak.
Most probably this implies that the assumption of the homogeneity of the
magnetic field inside the nebula is incorrect. On the other hand, the
time-dependent 1D spectral model provides a good fit of the new VHE results
when considering a 80 {\mu}G magnetic field. However, it fails to match the
data when including the morphology of the nebula at lower wavelengths.Comment: accepted by JHEAp, 9 pages, 6 figure
Detection of bridge emission above 50 GeV from the Crab pulsar with the MAGIC telescopes
The Crab pulsar is the only astronomical pulsed source detected at very high
energy (VHE, E>100GeV) gamma-rays. The emission mechanism of VHE pulsation is
not yet fully understood, although several theoretical models have been
proposed. In order to test the new models, we measured the light curve and the
spectra of the Crab pulsar with high precision by means of deep observations.
We analyzed 135 hours of selected MAGIC data taken between 2009 and 2013 in
stereoscopic mode. In order to discuss the spectral shape in connection with
lower energies, 4.6 years of {\it Fermi}-LAT data were also analyzed. The known
two pulses per period were detected with a significance of and
. In addition, significant emission was found between the two
pulses with . We discovered the bridge emission above 50 GeV
between the two main pulses. This emission can not be explained with the
existing theories. These data can be used for testing new theoretical models.Comment: 5 pages, 4 figure
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