HELP: the Herschel Extragalactic Legacy Project

We present the Herschel Extragalactic Legacy Project (HELP). This project collates, curates, homogenizes, and creates derived data products for most of the premium multiwavelength extragalactic data sets. The sky boundaries for the first data release cover 1270 deg2 defined by the Herschel SPIRE extragalactic survey fields; notably the Herschel Multi-tiered Extragalactic Survey (HerMES) and the Herschel Atlas survey (H-ATLAS). Here, we describe the motivation and principal elements in the design of the project. Guiding principles are transparent or ‘open’ methodologies with care for reproducibility and identification of provenance. A key element of the design focuses around the homogenization of calibration, meta data, and the provision of information required to define the selection of the data for statistical analysis. We apply probabilistic methods that extract information directly from the images at long wavelengths, exploiting the prior information available at shorter wavelengths and providing full posterior distributions rather than maximum-likelihood estimates and associated uncertainties as in traditional catalogues. With this project definition paper, we provide full access to the first data release of HELP; Data Release 1 (DR1), including a monolithic map of the largest SPIRE extragalactic field at 385 deg2 and 18 million measurements of PACS and SPIRE fluxes. We also provide tools to access and analyse the full HELP data base. This new data set includes far-infrared photometry, photometric redshifts, and derived physical properties estimated from modelling the spectral energy distributions over the full HELP sky. All the software and data presented is publicly available

Herschel multitiered extragalactic survey: Clusters of dusty galaxies uncovered by Herschel and Planck

The potential for Planck to detect clusters of dusty, star-forming galaxies at z > 1 is tested by examining the Herschel-SPIRE images of Planck Early Release Compact Source Catalog sources lying in fields observed by the Herschel Multitiered Extragalactic Survey. Of the 16 Planck sources that lie in the ~90 sq. deg. examined, we find that 12 are associated with single bright Herschel sources. The remaining four are associated with overdensities of Herschel sources, making them candidate clusters of dusty, star-forming galaxies. We use complementary optical/near-IR data for these 'clumps' to test this idea, and find evidence for the presence of galaxy clusters in all four cases. We use photometric redshiftsand red sequence galaxies to estimate the redshifts of these clusters, finding that they range from 0.8 to 2.3. These redshifts imply that the Herschel sources in these clusters, which contribute to the detected Planck flux, are forming stars very rapidly, with typical total cluster star formation rates > 1000M⊙ yr-1. The high-redshift clusters discovered inthese observations are used to constrain the epoch of cluster galaxy formation, finding that the galaxies in our clusters are 1-1.5 Gyr old at z ~ 1-2. Prospects for the discovery of further clusters of dusty galaxies are discussed, using not only all sky Planck surveys, but also deeper, smaller area, Herschel surveys. © 2014 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society

Spectroscopic properties of new IR galaxies detected in the European Large Area ISO Survey.

We present preliminary results of multi-object spectroscopy of new mid-, and far-infrared selected galaxies detected in the European Large Area ISO Survey (ELAIS). The data have been obtained with the fibre spectrographs WYFFOS at the William Herschel Telescope (Observatorio del Roque de los Muchachos, ORM, Canary Islands) and Hydra at the WIYN Telescope (Kitt Peak Observatory, Arizona). The sample includes ISO sources detected at 7, 15 and 90 microns and radio sources from our deep VLA survey in the ELAIS areas

Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment

A holistic understanding of tissue and organ structure and function requires the detection of molecular constituents in their original three-dimensional (3D) context. Imaging mass cytometry (IMC) enables simultaneous detection of up to 40 antigens and transcripts using metal-tagged antibodies but has so far been restricted to two-dimensional imaging. Here we report the development of 3D IMC for multiplexed 3D tissue analysis at single-cell resolution and demonstrate the utility of the technology by analysis of human breast cancer samples. The resulting 3D models reveal cellular and microenvironmental heterogeneity and cell-level tissue organization not detectable in two dimensions. 3D IMC will prove powerful in the study of phenomena occurring in 3D space such as tumor cell invasion and is expected to provide invaluable insights into cellular microenvironments and tissue architecture

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

The heterogeneity of breast cancer plays a major role in drug response and resistance and has been extensively characterized at the genomic level. Here, a single-cell breast cancer mass cytometry (BCMC) panel is optimized to identify cell phenotypes and their oncogenic signalling states in a biobank of patient-derived tumour xenograft (PDTX) models representing the diversity of human breast cancer. The BCMC panel identifies 13 cellular phenotypes (11 human and 2 murine), associated with both breast cancer subtypes and specific genomic features. Pre-treatment cellular phenotypic composition is a determinant of response to anticancer therapies. Single-cell profiling also reveals drug-induced cellular phenotypic dynamics, unravelling previously unnoticed intra-tumour response diversity. The comprehensive view of the landscapes of cellular phenotypic heterogeneity in PDTXs uncovered by the BCMC panel, which is mirrored in primary human tumours, has profound implications for understanding and predicting therapy response and resistance

The HerMES SPIRE submillimeter local luminosity function

Local luminosity functions are fundamental benchmarks for high-redshift galaxy formation and evolution studies as well as for models describing these processes. Determining the local luminosity function in the submillimeter range can help to better constrain in particular the bolometric luminosity density in the local Universe, and Herschel offers the first opportunity to do so in an unbiased way by imaging large sky areas at several submillimeter wavelengths. We present the first Herschel measurement of the submillimeter 0 < z < 0.2 local luminosity function and infrared bolometric (8-1000 μm) local luminosity density based on SPIRE data from the HerMES Herschel key program over 14.7 deg2. Flux measurements in the three SPIRE channels at 250, 350 and 500 μm are combined with Spitzer photometry and archival data. We fit the observed optical-to-submillimeter spectral energy distribution of SPIRE sources and use the 1/Vmax estimator to provide the first constraints on the monochromatic 250, 350 and 500 μm as well as on the infrared bolometric (8-1000 μm) local luminosity function based on Herschel data. We compare our results with modeling predictions and find a slightly more abundant local submillimeter population than predicted by a number of models. Our measurement of the infrared bolometric (8-1000 μm) local luminosity function suggests a flat slope at low luminosity, and the inferred local luminosity density, 1.31-0.21+0.24 × 108 L ⊙ Mpc-3, is consistent with the range of values reported in recent literature. © 2010 ESO

Localization and broadband follow-up of the gravitational-wave transient GW150914

A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams