Effects of using four baskets during simulated youth basketball games

© 2019 Mateus et al. This study aimed to identify how playing basketball with two additional baskets influences the players\u27 technical, physiological, physical and especially, positional performance. Fourteen youth players performed eight 5vs.5 simulated basketball games, four with the two official baskets and four with two-extra official baskets, each one placed in the court restricted area. The variables collected were technical (field-goals made and missed, offensive and defensive rebounds, steals, passes, dribble-drive, give-and-go and ball possessions), physiological (heart rate monotony and sample entropy), workload (total distance covered and distance covered at different velocities) and positioning-related (distance to the nearest opponent, distance to the nearest teammate, stretch-index and distance between centroids). The results showed that the four-baskets games favoured the emergence of individual behaviours, increasing the game\u27 physical demands and promoting a collective dispersion, which might impair team playing. Conversely, when playing with two-baskets, there was less distance between teammates. In conclusion, this study has clear implications for practice as it emphasizes that coaches can manipulate the number of baskets to modulate training workload and promote different individual and team behaviours

Current Knowledge on Pancreatic Cancer

Pancreatic cancer is the fourth leading cause of cancer death with a median survival of 6 months and a dismal 5-year survival rate of 3–5%. The development and progression of pancreatic cancer are caused by the activation of oncogenes, the inactivation of tumor suppressor genes, and the deregulation of many signaling pathways. Therefore, the strategies targeting these molecules as well as their downstream signaling could be promising for the prevention and treatment of pancreatic cancer. However, although targeted therapies for pancreatic cancer have yielded encouraging results in vitro and in animal models, these findings have not been translated into improved outcomes in clinical trials. This failure is due to an incomplete understanding of the biology of pancreatic cancer and to the selection of poorly efficient or imperfectly targeted agents. In this review, we will critically present the current knowledge regarding the molecular, biochemical, clinical, and therapeutic aspects of pancreatic cancer

A regulation-based classification system for marine protected areas: A response to Dudley et al. [9]

Dudley et al. [9] commented on our paper [11], arguing that the current IUCN objective-based categorization of protected areas, which is also used in marine protected areas (MPAs), should not be abandoned and replaced by the new regulation-based classification system [11]. Here we clarify that we do not advocate replacing the current IUCN categories, but highlight the benefits of using both the objective-based IUCN categories and the new regulation-based classification when applied to MPAs. With an increasing number of MPA types being implemented, most of them multiple-use areas zoned for various purposes, assessing ecological and socio-economic benefits is key for advancing conservation targets and policy objectives. Although the IUCN categories can be used both in terrestrial and marine systems, they were not designed to follow a gradient of impacts and there is often a mismatch between stated objectives and implemented regulations. The new regulation-based classification system addresses these problems by linking impacts of activities in marine systems with MPA and zone classes in a simple and globally applicable way. Applying both the IUCN categories and the regulation based classes will increase transparency when assessing marine conservation goals.ERA-Net BiodivERsA project "BUFFER Partially protected areas as buffers to increase the linked social ecological resilience"; national funders ANR (France); FCT (Portugal); FOR-MAS (Sweden); SEPA (Sweden); RCN (Norway); project BUFFER; Fernand Braudel IFER fellowship (Fondation Maison des Sciences de l'Homme); Fundacao para a Ciencia e a Tecnologia (FCT) [UID/MAR/04292/2013

Contribution of tumour and immune cells to PD-L1 expression as a predictive biomarker in metastatic triple-negative breast cancer: exploratory analysis from KEYNOTE-119

Pembrolizumab; Triple‐negative breast cancerPembrolizumab; Cáncer de mama triple negativoPembrolizumab; Càncer de mama triple negatiuThe efficacy of pembrolizumab monotherapy versus chemotherapy increased with increasing programmed death ligand 1 (PD-L1) expression, as quantified by combined positive score (CPS; PD-L1 expression on both tumour cells and immune cells) in patients with previously treated metastatic triple-negative breast cancer (mTNBC) in the phase 3 KEYNOTE-119 study. This exploratory analysis was conducted to determine whether the expression of PD-L1 on tumour cells contributes to the predictive value of PD-L1 CPS in mTNBC. PD-L1 expression in tumour samples was assessed using PD-L1 IHC 22C3 pharmDx and quantified using both CPS and tumour proportion score (TPS; PD-L1 expression on tumour cells alone). Calculated immune cell density (CID) was defined as CPS minus TPS. The ability of each scoring method (CPS, TPS, and CID) to predict clinical outcomes with pembrolizumab was evaluated. With pembrolizumab, the area under the receiver operating characteristic curve was 0.69 (95% CI = 0.58–0.80) for CPS, 0.55 (95% CI = 0.46–0.64) for TPS, and 0.67 (95% CI = 0.56–0.77) for CID. After correction for cutoff prevalence, CPS performed as well as, if not better than, CID with respect to predicting objective response rate, progression-free survival, and overall survival. Data from this exploratory analysis suggest that, although PD-L1 expression on immune cells alone is predictive of response to programmed death 1 blockade in mTNBC, adding tumour PD-L1 expression assessment (i.e. CPS, which combines immune cell and tumour cell PD-L1 expression) may improve prediction. PD-L1 CPS thus remains an effective and broadly applicable uniform scoring system for enriching response to programmed death 1 blockade with pembrolizumab in mTNBC as well as other tumour types

Achieving conservation through cattle ranching: The case of the Brazilian Pantanal

Cattle ranching in the ~140,000 km2 Brazilian Pantanal is considered one of the most important cases of sustainable use of natural resources in the global south. The region has had a successful history of balancing environmental protection with the production of >3.8 million cattle. However, global change, infrastructure projects, and deforestation, threaten the sustainable use of the Pantanal. Here, using Ostrom's design principles as a framework, we interviewed 49 local stakeholders and conducted a review of secondary information aiming to evaluate the sustainability of cattle ranching practices across the region and the threats to it. We show that well-defined property boundaries, congruence between appropriation and provision rules through low-intensity cattle ranching, and co-management of resources, are all key components for achieving sustainability in the Pantanal. However, we documented shortcomings in satisfying critical aspects of Orstrom's design principles. Specifically, we argue that the Pantanal needs better biodiversity and behavior monitoring, the creation of platforms or mechanisms to solve local conflicts around resource access and use, recognition by governments and international bodies of the local efforts to promote local sustainability, and the creation of networks effectively connecting existing sustainability initiatives

Off-training physical activity and training responses as determinants of sleep quality in young soccer players

This study aimed to quantify and assess the relationship of young soccer players' off-training physical activity (PA) and training responses on sleep quality. Eleven adolescent soccer players (13 ± 0.5 years old) were monitored during weekdays for four consecutive weeks throughout soccer practice days. Off-training PA and sleep quality were assessed using 100 Hz tri-axial accelerometers, and training responses analyzed using 20 Hz global positioning measurement units. A cluster analysis classified all cases into three different dimensions, (1) off-training PA, (2) training responses and (3) sleep quality. For each dimension, the most important variables for classifying the cases into clusters were sedentary PA and moderate-to-vigorous PA; total distance covered and impacts; and sleep onset latency and sleep fragmentation index, respectively. Afterwards, a correspondence analysis was used to identify whether off-training PA and training responses affected sleep quality. Results exposed that high to medium off-training PA combined with medium to high training responses may have decreased sleep quality. Conversely, no correspondence was observed between off-training PA and training responses, with higher sleep quality. This study emphasizes the importance of sports organizations adopting a holistic approach to youth soccer players’ development that appropriately considers the inter-relationship between lifestyle, performance and health-related information

Association between trochanteric bursitis, osteoarthrosis and total hip arthroplasty

AbstractObjectivethis was an epidemiological study on trochanteric bursitis at the time of performing total hip arthroplasty.Methodssixty-two sequential patients who underwent total hip arthroplasty due to osteoarthrosis, without any previous history of trochanteric bursitis, were evaluated. The bursas were collected and evaluated histologically.Resultsthere were 35 female patients (56.5%) and 27 male patients (43.5%), with a mean age of 65 years (±11). Trochanteric bursitis was conformed histologically in nine patients (14.5%), of whom six were female (66.7%) and three were male (33.3%).Conclusions14.5% of the bursas analyzed presented inflammation at the time that the primary total hip arthroplasty due to osteoarthrosis was performed, and the majority of the cases of bursitis were detected in female patients

Do patients lose weight after total hip arthroplasty?

AbstractObjectiveTo investigate the effect of total hip arthroplasty (THA) on body mass index (BMI), from before to after the operation.Methods100 patients who underwent THA were retrospectively analyzed. They were stratified according to BMI, as proposed by the World Health Organization (WHO).ResultsThere were 48 male patients and 52 female patients. Their mean age was 63.8±13.5 years. The mean follow-up was 24.6±0.6 months. The men had a mean preoperative BMI of 28.4±3.6kg/m2 and the women, 27.5±5.0kg/m2. The mean postoperative BMI was 28.9±0.7kg/m2 for the men and 27.8±0.7kg/m2 for the women. There was a general mean increase in BMI of 0.4kg/m2. The BMI increased both in patients with normal weight and in those who were overweight, but it decreased slightly in patients who were obese. BMI remained unchanged in the majority of the patients (73%).ConclusionThe improvement in mobility achieved through THA did not promote any reduction in anthropometric measurements in the majority of the patients

Wild dogs at stake: deforestation threatens the only Amazon endemic canid, the short-eared dog (Atelocynus microtis)

The persistent high deforestation rate and fragmentation of the Amazon forests are the main threats to their biodiversity. To anticipate and mitigate these threats, it is important to understand and predict how species respond to the rapidly changing landscape. The short-eared dog Atelocynus microtis is the only Amazon-endemic canid and one of the most understudied wild dogs worldwide. We investigated short-eared dog habitat associations on two spatial scales. First, we used the largest record database ever compiled for short-eared dogs in combination with species distribution models to map species habitat suitability, estimate its distribution range and predict shifts in species distribution in response to predicted deforestation across the entire Amazon (regional scale). Second, we used systematic camera trap surveys and occupancy models to investigate how forest cover and forest fragmentation affect the space use of this species in the Southern Brazilian Amazon (local scale). Species distribution models suggested that the short-eared dog potentially occurs over an extensive and continuous area, through most of the Amazon region south of the Amazon River. However, approximately 30% of the short-eared dog's current distribution is expected to be lost or suffer sharp declines in habitat suitability by 2027 (within three generations) due to forest loss. This proportion might reach 40% of the species distribution in unprotected areas and exceed 60% in some interfluves (i.e. portions of land separated by large rivers) of the Amazon basin. Our local-scale analysis indicated that the presence of forest positively affected short-eared dog space use, while the density of forest edges had a negative effect. Beyond shedding light on the ecology of the short-eared dog and refining its distribution range, our results stress that forest loss poses a serious threat to the conservation of the species in a short time frame. Hence, we propose a re-assessment of the short-eared dog's current IUCN Red List status (Near Threatened) based on findings presented here. Our study exemplifies how data can be integrated across sources and modelling procedures to improve our knowledge of relatively understudied species