Relationship between unilateral posterior crossbite and human static body posture

Background: We compared photogrammetry-assessed body posture between young adults with and without unilateral posterior crossbite (UPCB). Assessments were controlled by vision, mandibular position and sitting/standing position. In addition, we aimed to determine the relationship between UPCB laterality and the direction of body posture using photogrammetry and a static postural platform. Methods: Adults with natural dentition, with and without UPCB, were enrolled. Static body posture was assessed by photogrammetry based on horizontal acromial alignment and horizontal anterior-superior iliac spine (ASIS) alignment. Frontal photographs were taken with participants asked to open or close their eyes and hold their jaws at rest, at an intercuspal position, and at left or right lateral positions. Distribution of foot pressure was recorded using a static postural platform at different visual input and mandibular positions. General linear models with repeated measures were used to assess the effect of the various within- and between-subject factors. Results: In total, 36 adults (left UPCB = 12; Right UPCB = 6; controls = 18) participated. There were significant differences between the control and UPCB groups in horizontal alignment at the acromion (p = 0.035) and ASIS (p = 0.026) levels when controlled by visual input and mandibular position. No significant differences in horizontal alignment or foot pressure distribution were observed by laterality in the UPCB group. Conclusion: The presence of UPCB affects static body posture, but the side of crossbite is not related to the direction of effect on static body posture

Effectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors: Inverse Probability of Treatment Weighting Analysis of a Population-Based Registry

Stroke; Thrombectomy; PrognosisIctus; Trombectomia; PronòsticIctus; Trombectomía; PronósticoBackground and purpose: In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors. Methods: Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score ≤2) and survival at 3 months was studied using inverse probability of treatment weighting (IPTW) analysis in three pre-defined baseline prognostic groups: poor (if pre-stroke disability, age >85 years, National Institutes of Health Stroke Scale [NIHSS] >25, time from onset >6 hours, Alberta Stroke Program Early CT Score 3), good (if NIHSS <6 or distal occlusion, in the absence of poor prognostic factors), or reference (not meeting other groups' criteria). Results: Patients receiving MT (n=1,996, 77%) were younger, had less pre-stroke disability, and received systemic thrombolysis less frequently. These differences were balanced after the IPTW stratified by prognosis. MT was associated with good functional outcome in the reference (odds ratio [OR], 2.9; 95% confidence interval [CI], 2.0 to 4.4), and especially in the poor baseline prognostic stratum (OR, 3.9; 95% CI, 2.6 to 5.9), but not in the good prognostic stratum. MT was associated with survival only in the poor prognostic stratum (OR, 2.6; 95% CI, 2.0 to 3.3). Conclusions: Despite their worse overall outcomes, the impact of thrombectomy over medical management was more substantial in patients with poorer baseline prognostic factors than patients with good prognostic factors

Impact of sensory marketing on food tourism decisions in restaurants

[Resumen] El objetivo principal de este trabajo es conocer los efectos del marketing sensorial sobre las decisiones de los clientes de restaurantes al hacer turismo gastronómico. La metodología utilizada es de tipo cuantitativo, a partir de los resultados de una encuesta, a los que se ha aplicado análisis estadístico descriptivo y bivariado. Los principales resultados indican que el 32,30% de los participantes señala al turismo gastronómico como uno de sus motivos preferentes para viajar a un destino y que el 35,2% estaría dispuesto a pagar más por una experiencia multisensorial en un restaurante. Se concluye que las empresas e instituciones involucradas en un sector tan competitivo deben apostar firmemente por la utilización de las técnicas propias del marketing sensorial, pues los turistas gastronómicos muestran preferencias sensoriales muy concretas sobre determinados aspectos relacionados con la vista (luz), olfato (olores más o menos fuertes), gusto (platos), oído (música ambiental) o tacto (materiales).[Abstract] The main aim of this article is to examine the effect of sensory marketing on the decisions of restaurant customers when travelling as food tourists. The study is based on a quantitative descriptive and bivariate statistical analysis of the results of a survey. The results show that 32.30% of the participants identify food tourism as one of their main reasons for travelling to a specific destination and that 35.2% would be willing to pay more to enjoy a multisensory experience in a restaurant. The study concludes that the companies and institutions involved in this competitive sector must move to adopt the techniques of sensory marketing, since food tourists show very specific sensory preferences in relation to sight (light), smell (more or less strong smells), taste (dishes), hearing (ambient music) and touch (materials)

Impacto del marketing sensorial en decisiones del turista gastronómico en restaurantes

The main aim of this article is to examine the effect of sensory marketing on the decisions of restaurant customers when travelling as food tourists. The study is based on a quantitative descriptive and bivariate statistical analysis of the results of a survey. The results show that 32.30% of the participants identify food tourism as one of their main reasons for travelling to a specific destination and that 35.2% would be willing to pay more to enjoy a multisensory experience in a restaurant. The study concludes that the companies and institutions involved in this competitive sector must move to adopt the techniques of sensory marketing, since food tourists show very specific sensory preferences in relation to sight (light), smell (more or less strong smells), taste (dishes), hearing (ambient music) and touch (materials).El objetivo principal de este trabajo es conocer los efectos del marketing sensorial sobre las decisiones de los clientes de restaurantes al hacer turismo gastronómico. La metodología utilizada es de tipo cuantitativo, a partir de los resultados de una encuesta, a los que se ha aplicado análisis estadístico descriptivo y bivariado. Los principales resultados indican que el 32,30% de los participantes señala al turismo gastronómico como uno de sus motivos preferentes para viajar a un destino y que el 35,2% estaría dispuesto a pagar más por una experiencia multisensorial en un restaurante. Se concluye que las empresas e instituciones involucradas en un sector tan competitivo deben apostar firmemente por la utilización de las técnicas propias del marketing sensorial, pues los turistas gastronómicos muestran preferencias sensoriales muy concretas sobre determinados aspectos relacionados con la vista (luz), olfato (olores más o menos fuertes), gusto (platos), oído (música ambiental) o tacto (materiales)

Circadian rhythms in the efficacy of intravenous alteplase in patients with acute ischemic stroke and middle cerebral artery occlusion

Peer ReviewedPostprint (author's final draft

Endovascular treatment improves cognition after stroke. A secondary analysis of REVASCAT trial

Objective: To investigate the effect of endovascular treatment on cognitive function as a prespecified secondary analysis of the REVASCAT (Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours) trial. Methods: REVASCAT randomized 206 patients with anterior circulation proximal arterial occlusion stroke to Solitaire thrombectomy or best medical treatment alone. Patients with established dementia were excluded from enrollment. Cognitive function was assessed in person with Trail Making Test (TMT) Parts A and B at 3 months and 1 year after randomization by an investigator masked to treatment allocation. Test completion within 5 minutes, time of completion (seconds), and number of errors were recorded. Results: From November 2012 to December 2014, 206 patients were enrolled in REVASCAT. TMT was assessed in 82 of 84 patients undergoing thrombectomy and 86 of 87 control patients alive at 3 months and in 71 of 79 patients undergoing thrombectomy and 72 of 78 control patients alive at 1 year. Rates of timely TMT-A completion were similar in both treatment arms, although patients undergoing thrombectomy required less time for TMT-A completion and had higher rates of error-free TMT-A performance. Thrombectomy was also associated with a higher probability of timely TMT-B completion (adjusted odds ratio 3.17, 95% confidence interval 1.51-6.66 at 3 months; and adjusted ratio 3.66, 95% confidence interval 1.60-8.35 at 1 year) and shorter time for TMT-B completion. Differences in TMT completion times between treatment arms were significant in patients with good functional outcome but not in those who were functionally dependent (modified Rankin Scale score >2). Poorer cognitive outcomes were significantly associated with larger infarct volume, higher modified Rankin Scale scores, and worse quality of life. Conclusions: Thrombectomy improves TMT performance after stroke, especially among patients who reach good functional recovery. Classification of evidence: This study provides Class I evidence that for patients with stroke from acute anterior circulation proximal arterial occlusion, thrombectomy improves performance on the TMT at 3 months

Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients : Study protocol of the MindFit project randomized controlled trial

Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized cognitive training (CCT) may benefit stroke patients by impacting neuroplasticity and brain health. One hundred and forty-one chronic stroke patients are randomly allocated to receive mindfulness-based stress reduction + CCT (n = 47), multicomponent PE program + CCT (n = 47), or CCT alone (n = 47). Interventions consist of 12-week home-based programs five days per week. Before and after the interventions, we collect data from cognitive, psychological, and physical tests, blood and stool samples, and structural and functional brain scans. The effects of the interventions on cognitive and emotional outcomes will be described in intention-to-treat and per-protocol analyses. We will also explore potential mediators and moderators, such as genetic, molecular, brain, demographic, and clinical factors in our per-protocol sample. The MindFit Project is a randomized clinical trial that aims to assess the impact of mindfulness and PE combined with CCT on chronic stroke patients' cognitive and emotional wellbeing. Furthermore, our design takes a multimodal biopsychosocial approach that will generate new knowledge at multiple levels of evidence, from molecular bases to behavioral changes. , identifier NCT04759950

Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients: Study protocol of the MindFit project randomized controlled trial

Background: Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized cognitive training (CCT) may benefit stroke patients by impacting neuroplasticity and brain health. Materials and methods: One hundred and forty-one chronic stroke patients are randomly allocated to receive mindfulness-based stress reduction + CCT (n = 47), multicomponent PE program + CCT (n = 47), or CCT alone (n = 47). Interventions consist of 12-week home-based programs five days per week. Before and after the interventions, we collect data from cognitive, psychological, and physical tests, blood and stool samples, and structural and functional brain scans. Results: The effects of the interventions on cognitive and emotional outcomes will be described in intention-to-treat and per-protocol analyses. We will also explore potential mediators and moderators, such as genetic, molecular, brain, demographic, and clinical factors in our per-protocol sample. Discussion: The MindFit Project is a randomized clinical trial that aims to assess the impact of mindfulness and PE combined with CCT on chronic stroke patients' cognitive and emotional wellbeing. Furthermore, our design takes a multimodal biopsychosocial approach that will generate new knowledge at multiple levels of evidence, from molecular bases to behavioral changes. Clinical trial registration: www.ClinicalTrials.gov, identifier NCT04759950

Effectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors: Inverse Probability of Treatment Weighting Analysis of a Population-Based Registry

Background and Purpose In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors. Methods Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score 85 years, National Institutes of Health Stroke Scale [NIHSS] >25, time from onset >6 hours, Alberta Stroke Program Early CT Score 3), good (if NIHSS <6 or distal occlusion, in the absence of poor prognostic factors), or reference (not meeting other groups' criteria). Results Patients receiving MT (n=1,996, 77%) were younger, had less pre-stroke disability, and received systemic thrombolysis less frequently. These differences were balanced after the IPTW stratified by prognosis. MT was associated with good functional outcome in the reference (odds ratio [OR], 2.9; 95% confidence interval [CI], 2.0 to 4.4), and especially in the poor baseline prognostic stratum (OR, 3.9; 95% CI, 2.6 to 5.9), but not in the good prognostic stratum. MT was associated with survival only in the poor prognostic stratum (OR, 2.6; 95% CI, 2.0 to 3.3). Conclusions Despite their worse overall outcomes, the impact of thrombectomy over medical management was more substantial in patients with poorer baseline prognostic factors than patients with good prognostic factors

Comparison of the impact of atrial fibrillation on the risk of early death after stroke in women versus men

BACKGROUND: Atrial fibrillation (AF) is considered a predictive factor of poor clinical outcome in patients with an ischemic stroke (IS). This study addressed whether the impact of AF on the in-hospital mortality after first ever IS is different according to the patient’s gender. METHODS: We prospectively studied 1678 patients with first ever IS consecutively admitted to two University Hospitals. We recorded demographic data, vascular risk factors, and the stroke severity (NIHSS) at admission analyzing their impact on the in-hospital mortality and on the combined mortality-dependency at discharge using a Cox proportional hazards model. Two variable interactions between those factors independently related to in-hospital mortality and combined mortality-dependency at discharge were tested. RESULTS: Overall in-hospital mortality was 11.3%. Cox proportional hazards model showed that NIHSS at admission (HR: 1.178 [95% CI 1.149–1.207]), age (HR: 1.044 [95% CI 1.026–1.061]), AF (HR: 1.416 [95% CI 1.048–1.913]), male gender (HR: 1.853 [95% CI 1.323–2.192) and ischemic heart disease (HR: 1.527 [95% CI 1.063–2.192]) were independent predictors of in-hospital mortality. A significant interaction between gender and AF was found (p = 0.017). Data were stratified by gender, showing that AF was an independent predictor of poor outcome just for woman (HR: 2.183 [95% CI 1.403–3.396]; p < 0.001). The independent predictors of combined mortality-disability at discharge were NIHSS at admission (HR: 1.052 [95% CI 1.041–1.063]), age (HR: 1.011 [95% CI 1.004–1.018]), AF (HR: 1.197 [95% CI 1.031–1.390]), ischemic heart disease (HR: 1.222 [95% CI 1.004–1.488]), and smoking (HR: 1.262 [95% CI 1.033–1.541]). CONCLUSIONS: The impact of AF is different in the twogenders and appears as a specific ischemic stroke predictor of in-hospital mortality just for women